PANTHER Gene Information

Gene Symbol(s):

PIK3C2A

Organism:

Homo sapiens

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Gene Name:

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

Gene ID:

HGNC:8971

Protein ID:

O00443

Enhancers:

View enhancers for HUMAN|HGNC=8971|UniProtKB=O00443

Genetic Variant Annotation:

Annoq

Persistent Id:

PTN002467573

Alternate Ids:

2.7.1.153 {ECO:0000269\|PubMed:11239472, ECO:0000269\|PubMed:9337861}(EC)	AC126389(EMBL)
2143260(GI)	PtdIns-3-kinase C2 subunit alpha(Synonym)
Q14CQ9(AltAccession)	P3C2A_HUMAN(UniProtKB-ID)
CHEMBL1075102(ChEMBL)	AAI13659(EMBL-CDS)
ENSG00000011405(Ensembl)	PIK3C2A(Symbol)
XM_017017924(refSeq)	MetaCyc:HS00315-MON(BioCyc)
HGNC:8971(HGNC)	603601(MIM)
5286(GeneID)
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PANTHER Classification

PANTHER Family:	PHOSPHATIDYLINOSITOL KINASE (PTHR10048)
PANTHER Subfamily:	PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA (PTHR10048:SF28)
PANTHER GO-slim Molecular Function:	lipid kinase activity phosphotransferase activity, alcohol group as acceptor
PANTHER GO-slim Biological Process:	cell migration phosphatidylinositol phosphate biosynthetic process phosphatidylinositol 3-kinase/protein kinase B signal transduction
PANTHER GO-slim Cellular Component:	phosphatidylinositol 3-kinase complex plasma membrane cytoplasm
PANTHER protein class:	kinase

Pathway Categories:

VEGF signaling pathway

Phosphatidylinositol 3-kinase

Hypoxia response via HIF activation

Phosphatidylinositol 3-kinase

Insulin/IGF pathway-protein kinase B signaling cascade

Phosphatidylinositol 3-kinase

FGF signaling pathway

Phosphatidylinositol 3-kinase

Angiogenesis

Phosphatidylinositol 3-kinase

EGF receptor signaling pathway

Phosphatidylinositol 3-kinase

Integrin signalling pathway

Phosphatidylinositol 3-kinase

Axon guidance mediated by netrin

Phosphatidylinositol 3-kinase

Endothelin signaling pathway

Phosphatidylinositol 3-kinase

p53 pathway feedback loops 2

Phosphatidylinositol 3-kinase

p53 pathway

Phosphatidylinositol 3-kinase

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	ATP binding, phosphatidylinositol binding, clathrin binding, 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, 1-phosphatidylinositol-3-kinase activity
GO BP Complete:	membrane organization, insulin receptor signaling pathway, epidermal growth factor receptor signaling pathway, phosphatidylinositol-3-phosphate biosynthetic process, platelet-derived growth factor receptor signaling pathway, phosphatidylinositol biosynthetic process, endocytosis, positive regulation of cell migration involved in sprouting angiogenesis, exocytosis, positive regulation of autophagy, phosphatidylinositol 3-kinase/protein kinase B signal transduction, vascular associated smooth muscle contraction, phosphatidylinositol-mediated signaling, clathrin coat assembly, cell migration
GO CC Complete:	trans-Golgi network, extracellular exosome, cytoplasm, intracellular membrane-bounded organelle, membrane, cytosol, vesicle, clathrin-coated vesicle, plasma membrane, nucleoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Membrane Trafficking, PI Metabolism, trans-Golgi Network Vesicle Budding, Synthesis of PIPs at the late endosome membrane, Synthesis of PIPs at the early endosome membrane, Phospholipid metabolism, Synthesis of PIPs at the Golgi membrane, Synthesis of PIPs at the plasma membrane, Golgi Associated Vesicle Biogenesis, Metabolism, Clathrin-mediated endocytosis, Metabolism of lipids, Vesicle-mediated transport

Orthologs

ID	Organism	Type
PANTR\|Ensembl=ENSPTRG00000003399.5\|UniProtKB=H2Q383	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000011040.3\|UniProtKB=G3RRS8	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000022548.4\|UniProtKB=F6Y9J9	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1203729\|UniProtKB=Q61194	Mus musculus	LDO
RAT\|RGD=1310389\|UniProtKB=D3ZTF6	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000004901.6\|UniProtKB=E1BE68	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000025406.3\|UniProtKB=I3LLX2	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000014963.4\|UniProtKB=F6U9E2	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000023161.4\|UniProtKB=A0A2I2UT47	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845027085.1\|UniProtKB=A0A8I3SAR3	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000007062.5\|UniProtKB=F6PV08	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000007685.3\|UniProtKB=F6VDD2	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010023209.1\|UniProtKB=A0A8V0ZLS9	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000000045.4\|UniProtKB=G1K875	Anolis carolinensis	LDO
XENLA\|Gene=pik3c2a.S\|UniProtKB=A0A1L8GEH2	Xenopus laevis	O
XENLA\|Gene=pik3c2a.L\|UniProtKB=A0A1L8GIB5	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-484563\|UniProtKB=F6SUB4	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000001292.2\|UniProtKB=A0A3B3IHY8	Oryzias latipes	LDO
DANRE\|Gene=pik3c2a\|UniProtKB=A0A8M2B5U1	Danio rerio	LDO
DANRE\|Ensembl=ENSDARG00000109612.1\|UniProtKB=A0A2R8QSP1	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000002963.1\|UniProtKB=W5M537	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000023383.1\|UniProtKB=H2Y1I5	Ciona intestinalis	O
BRAFL\|Gene=LOC118414477\|UniProtKB=A0A9J7L1K4	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC586734\|UniProtKB=A0A7M7P313	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00009552\|UniProtKB=G5EDY0	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG07670\|UniProtKB=A8X4B6	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00095713\|UniProtKB=A0A2A6BJJ3	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0015278\|UniProtKB=Q7K3H0	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP011036\|UniProtKB=A0A1S4H5J3	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC034925\|UniProtKB=A0A139WAA5	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_303261\|UniProtKB=E9FU84	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW004026\|UniProtKB=B7PIF4	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW022811\|UniProtKB=B7QET6	Ixodes scapularis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g90881\|UniProtKB=A7RRA6	Nematostella vectensis	O
MONBE\|EnsemblGenome=MONBRDRAFT_28086\|UniProtKB=A9V757	Monosiga brevicollis	O
ENTH1\|EnsemblGenome=EHI_188970\|UniProtKB=C4M2W4	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_006130\|UniProtKB=C4M2P7	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_095130\|UniProtKB=C4M4S6	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_040690\|UniProtKB=C4M5P0	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_009890\|UniProtKB=C4M0Q4	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_013980\|UniProtKB=C4LXN9	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0268548\|UniProtKB=Q55FX5	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_38568\|UniProtKB=F0ZUR5	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0291093\|UniProtKB=Q54F55	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_96754\|UniProtKB=F0ZAX6	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0283081\|UniProtKB=P54674	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_52203\|UniProtKB=F0Z7E7	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0282625\|UniProtKB=Q54S78	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_35373\|UniProtKB=F0ZP96	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0275011\|UniProtKB=P54675	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_149892\|UniProtKB=F0ZEX7	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0278727\|UniProtKB=P54673	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_58194\|UniProtKB=F0ZZM8	Dictyostelium purpureum	O
GIAIC\|EnsemblGenome=GL50803_14855\|UniProtKB=A8B5J3	Giardia intestinalis	O
TRIV3\|Gene_ORFName=TVAG_393100\|UniProtKB=A2DYA6	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_344900\|UniProtKB=A2F0T8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_083340\|UniProtKB=A2DM61	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_284350\|UniProtKB=A2EN93	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_101460\|UniProtKB=A2DJM8	Trichomonas vaginalis	O
PARTE\|EnsemblGenome=GSPATT00018694001\|UniProtKB=A0DN72	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00019938001\|UniProtKB=A0DT78	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00012877001\|UniProtKB=A0D2V1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00027505001\|UniProtKB=A0EIN5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00039649001\|UniProtKB=A0DLV0	Paramecium tetraurelia	O
PHYRM\|Gene=H3GL97_PHYRM\|UniProtKB=H3GL97	Phytophthora ramorum	O
PHYRM\|Gene=H3GLA1_PHYRM\|UniProtKB=H3GLA1	Phytophthora ramorum	O
KLENI\|Gene_ORFName=KFL_003910060\|UniProtKB=A0A1Y1IAN1	Klebsormidium nitens	O