PANTHER Gene Information   
Gene Symbol(s): PIK3R2
Organism: Homo sapiens
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Gene Name: Phosphatidylinositol 3-kinase regulatory subunit beta
Gene ID: HGNC:8980
Protein ID: O00459
Enhancers: View enhancers for HUMAN|HGNC=8980|UniProtKB=O00459
Genetic Variant Annotation: Annoq
Persistent Id: PTN002468388
Alternate Ids:
NM_005027(refSeq) AAH90249(EMBL-CDS)
MetaCyc:ENSG00000105647-MON(BioCyc) ENSG00000105647(Ensembl)
BC070082(EMBL) 2160048(GI)
CHEMBL4437(ChEMBL) Q9UPH9(AltAccession)
603387(MIM) ENSP00000222254(Ensembl_PRO)
PIK3R2(Symbol) PI3-kinase subunit p85-beta(Synonym)
P85B_HUMAN(UniProtKB-ID) ENST00000222254(Ensembl_TRS)
5296(GeneID) HGNC:8980(HGNC)
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PANTHER Classification
PANTHER Family: PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT (PTHR10155)
PANTHER Subfamily: PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA (PTHR10155:SF1)  
PANTHER GO-slim Molecular Function: kinase regulator activity
PANTHER GO-slim Biological Process: phosphatidylinositol phosphate biosynthetic process
insulin receptor signaling pathway
PANTHER GO-slim Cellular Component: phosphatidylinositol 3-kinase complex
PANTHER protein class: kinase modulator
Pathway Categories: VEGF signaling pathway
   Phosphatidylinositol 3-kinase
PI3 kinase pathway
   p85
T cell activation
   Phosphatidylinositol 3-kinase
Hypoxia response via HIF activation
   Phosphatidylinositol 3-kinase
Insulin/IGF pathway-protein kinase B signaling cascade
   Phosphatidylinositol 3-kinase
Angiogenesis
   Phosphatidylinositol 3-kinase
Integrin signalling pathway
   Phosphatidylinositol 3-kinase
Axon guidance mediated by netrin
   Phosphatidylinositol 3-kinase
Endothelin signaling pathway
   Phosphatidylinositol 3-kinase
PDGF signaling pathway
   Phosphatidylinositol 3-kinase
p53 pathway feedback loops 2
   Phosphatidylinositol 3-kinase
p53 pathway
   Phosphatidylinositol 3-kinase

GO MF Complete: phosphotyrosine residue binding, protein binding, protein phosphatase binding, phosphatidylinositol 3-kinase regulatory subunit binding, protein heterodimerization activity, receptor tyrosine kinase binding, 1-phosphatidylinositol-3-kinase regulator activity
GO BP Complete: regulation of protein localization to plasma membrane, positive regulation of protein import into nucleus, B cell differentiation, insulin receptor signaling pathway, negative regulation of MAPK cascade, protein transport, regulation of stress fiber assembly, positive regulation of cell adhesion, positive regulation of transcription by RNA polymerase II, T cell differentiation, regulation of actin filament polymerization, cellular response to insulin stimulus, phosphatidylinositol 3-kinase/protein kinase B signal transduction, immune response, intracellular glucose homeostasis, regulation of autophagy, response to endoplasmic reticulum stress
GO CC Complete: phosphatidylinositol 3-kinase complex, class IA, nucleus, focal adhesion, cytosol
Reactome Pathways: Fc epsilon receptor (FCERI) signaling, MAPK family signaling cascades, Cell-Cell communication, Signaling by ALK in cancer, Regulation of signaling by CBL, Platelet activation, signaling and aggregation, Signaling by Rho GTPases, Diseases of signal transduction by growth factor receptors and second messengers, Downstream TCR signaling, Signaling by NTRKs, G alpha (q) signalling events, PIP3 activates AKT signaling, RAC1 GTPase cycle, Signaling by PDGFRA extracellular domain mutants, RAC3 GTPase cycle, CDC42 GTPase cycle, DAP12 interactions, RHOB GTPase cycle, RHOU GTPase cycle, Signaling by Receptor Tyrosine Kinases, Costimulation by the CD28 family, RAF/MAP kinase cascade, Signaling by Nuclear Receptors, Signaling by PDGFR in disease, MAPK1/MAPK3 signaling, Tie2 Signaling, Role of LAT2/NTAL/LAB on calcium mobilization, Signaling by Insulin receptor, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Synthesis of PIPs at the plasma membrane, Insulin receptor signalling cascade, Cell surface interactions at the vascular wall, Metabolism, Interleukin-2 family signaling, Downstream signal transduction, Metabolism of lipids, Axon guidance, Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants, VEGFA-VEGFR2 Pathway, Signaling by SCF-KIT, Intracellular signaling by second messengers, PI3K Cascade, PI Metabolism, PI3K/AKT Signaling in Cancer, DAP12 signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Signaling by Interleukins, Phospholipid metabolism, Signaling by KIT in disease, ESR-mediated signaling, Signaling by VEGF, RND1 GTPase cycle, Extra-nuclear estrogen signaling, RHOJ GTPase cycle, IRS-mediated signalling, Signaling by GPCR, RHO GTPase cycle, Signal Transduction, TCR signaling, Fcgamma receptor (FCGR) dependent phagocytosis, RHOD GTPase cycle, Innate Immune System, Signaling by ALK, RHOA GTPase cycle, IRS-related events triggered by IGF1R, RAC2 GTPase cycle, Hemostasis, Developmental Biology, IGF1R signaling cascade, Constitutive Signaling by Aberrant PI3K in Cancer, Signaling by ALK fusions and activated point mutants, Signaling by PDGF, RHOF GTPase cycle, Role of phospholipids in phagocytosis, CD28 dependent PI3K/Akt signaling, CD28 co-stimulation, Interleukin-7 signaling, GPCR downstream signalling, Nephrin family interactions, PI3K/AKT activation, GPVI-mediated activation cascade, Disease, RND3 GTPase cycle, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Negative regulation of the PI3K/AKT network, RND2 GTPase cycle, RET signaling, Cytokine Signaling in Immune system, Interleukin receptor SHC signaling, Immune System, Signaling by NTRK1 (TRKA), Adaptive Immune System, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants, Nervous system development