PANTHER Gene Information   
Gene Symbol(s): Pik3cd
Organism: Mus musculus
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Gene Name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Gene ID: MGI:1098211
Protein ID: O35904
Persistent Id: PTN000005850
Alternate Ids:
CU207384(EMBL) 283806781(GI)
Pik3cd(Symbol) PI3K-delta(Synonym)
Q8CJ28(AltAccession) 2.7.1.153 {ECO:0000250|UniProtKB:O00329}(EC)
MGI:1098211(MGI) PK3CD_MOUSE(UniProtKB-ID)
CHEMBL2216745(ChEMBL) 18707(GeneID)
EDL14872(EMBL-CDS) ENSMUSG00000039936(Ensembl)
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PANTHER Classification
PANTHER Family: PHOSPHATIDYLINOSITOL KINASE (PTHR10048)
PANTHER Subfamily: PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (PTHR10048:SF35)  
PANTHER GO-slim Molecular Function: lipid kinase activity
phosphotransferase activity, alcohol group as acceptor
PANTHER GO-slim Biological Process: cell migration
phosphatidylinositol phosphate biosynthetic process
phosphatidylinositol 3-kinase/protein kinase B signal transduction
PANTHER GO-slim Cellular Component: phosphatidylinositol 3-kinase complex
plasma membrane
cytoplasm
PANTHER protein class: kinase
Pathway Categories: T cell activation
   Phosphatidylinositol 3-kinase
Ras Pathway
   Phosphatidylinositol 3-kinase
Insulin/IGF pathway-protein kinase B signaling cascade
   Phosphatidylinositol 3-kinase
Inflammation mediated by chemokine and cytokine signaling pathway
   Phosphatidylinositol 3-kinase
Endothelin signaling pathway
   Phosphatidylinositol 3-kinase
p53 pathway feedback loops 2
   Phosphatidylinositol 3-kinase
p53 pathway
   Phosphatidylinositol 3-kinase
VEGF signaling pathway
   Phosphatidylinositol 3-kinase
Hypoxia response via HIF activation
   Phosphatidylinositol 3-kinase
FGF signaling pathway
   Phosphatidylinositol 3-kinase
EGF receptor signaling pathway
   Phosphatidylinositol 3-kinase
Angiogenesis
   Phosphatidylinositol 3-kinase
Integrin signalling pathway
   Phosphatidylinositol 3-kinase
Axon guidance mediated by netrin
   Phosphatidylinositol 3-kinase
PDGF signaling pathway
   Phosphatidylinositol 3-kinase
B cell activation
   Phosphatidylinositol 3-kinase
Apoptosis signaling pathway
   Phosphatidylinositol 3-kinase
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: ATP binding, protein binding, 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, 1-phosphatidylinositol-3-kinase activity
GO BP Complete: positive regulation of neutrophil apoptotic process, positive regulation of epithelial tube formation, phosphatidylinositol-3-phosphate biosynthetic process, vascular endothelial growth factor signaling pathway, adaptive immune response, cell surface receptor signaling pathway, B cell activation, B cell homeostasis, positive regulation of angiogenesis, chemotaxis, negative regulation of gene expression, inflammatory response, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol-mediated signaling, positive regulation of gene expression, innate immune response, homeostasis of number of cells, cell differentiation, positive regulation of endothelial cell proliferation, defense response to fungus, positive regulation of endothelial cell migration, cell migration, positive regulation of cell migration
GO CC Complete: phosphatidylinositol 3-kinase complex, class IA, phosphatidylinositol 3-kinase complex, cytoplasm, cytosol, plasma membrane
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Immune System, Interleukin receptor SHC signaling, Negative regulation of the PI3K/AKT network, Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Axon guidance, PIP3 activates AKT signaling, Metabolism of lipids, Signaling by the B Cell Receptor (BCR), Signaling by Erythropoietin, Developmental Biology, Interleukin-2 family signaling, Nervous system development, Signal Transduction, Synthesis of PIPs at the plasma membrane, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, RET signaling, Intracellular signaling by second messengers, Interleukin-3, Interleukin-5 and GM-CSF signaling, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, Signaling by Interleukins, Phospholipid metabolism, Metabolism, PI Metabolism, Cytokine Signaling in Immune system, Regulation of signaling by CBL, Adaptive Immune System

Orthologs