PANTHER Gene Information   
Gene Symbol(s): GNAO1
Organism: Homo sapiens
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Gene Name: Guanine nucleotide-binding protein G(o) subunit alpha
Gene ID: HGNC:4389
Protein ID: P09471
Enhancers: View enhancers for HUMAN|HGNC=4389|UniProtKB=P09471
Genetic Variant Annotation: Annoq
Persistent Id: PTN002469289
Alternate Ids:
2775(GeneID) P29777(AltAccession)
617493(MIM) HGNC:4389(HGNC)
GNAO1(Symbol) CHEMBL4742(ChEMBL)
M60158(EMBL) GNAO(Synonym)
ENSG00000087258(Ensembl) AAM12608(EMBL-CDS)
GNAO_HUMAN(UniProtKB-ID) 20147683(GI)
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PANTHER Classification
PANTHER Family: GTP-BINDING PROTEIN ALPHA SUBUNIT (PTHR10218)
PANTHER Subfamily: GUANINE NUCLEOTIDE-BINDING PROTEIN G(O) SUBUNIT ALPHA (PTHR10218:SF361)  
PANTHER GO-slim Molecular Function: GTPase activity
G protein-coupled receptor binding
protein-containing complex binding
hormone receptor binding
PANTHER GO-slim Biological Process: adenylate cyclase-modulating G protein-coupled receptor signaling pathway
dopamine receptor signaling pathway
PANTHER GO-slim Cellular Component: plasma membrane protein complex
extrinsic component of membrane
cytoplasm
catalytic complex
cytoplasmic side of plasma membrane
PANTHER protein class: heterotrimeric G-protein
Pathway Categories: Endogenous cannabinoid signaling
   Gi/o-protein, alpha subunit
Gonadotropin-releasing hormone receptor pathway
   gnai/o
5HT1 type receptor mediated signaling pathway
   G-protein
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
   Go alpha subunit
Inflammation mediated by chemokine and cytokine signaling pathway
   Gi/q-protein, alpha subunit
Enkephalin release
   Gi-protein
Opioid prodynorphin pathway
   G-protein
Opioid proopiomelanocortin pathway
   G-protein
Inflammation mediated by chemokine and cytokine signaling pathway
   Gi-protein, alpha subunit
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
   Gi-protein
GABA-B receptor II signaling
   G-protein (i/o), alpha subunit
Metabotropic glutamate receptor group II pathway
   G-protein

GO MF Complete: GTP binding, protein binding, metal ion binding, corticotropin-releasing hormone receptor 1 binding, GTPase activity, G-protein beta/gamma-subunit complex binding, G protein-coupled serotonin receptor binding, mu-type opioid receptor binding
GO BP Complete: locomotory behavior, muscle contraction, vesicle docking involved in exocytosis, G protein-coupled dopamine receptor signaling pathway, regulation of heart contraction, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, negative regulation of insulin secretion
GO CC Complete: dendrite, heterotrimeric G-protein complex, cytoplasm, cell body, plasma membrane
Reactome Pathways: Signal Transduction, Ca2+ pathway, Signaling by WNT, Beta-catenin independent WNT signaling