PANTHER Gene Information   
Gene Symbol(s): Prkar2a
Organism: Rattus norvegicus
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Gene Name: cAMP-dependent protein kinase type II-alpha regulatory subunit
Gene ID: 3393
Protein ID: P12368
Persistent Id: PTN000180623
Alternate Ids:
ENSRNOG00000020284(Ensembl) AAA41856(EMBL-CDS)
KAP2_RAT(UniProtKB-ID) 83304285(GI)
NP_062137(refSeq) G3V8Q6(AltAccession)
ENSRNOT00000027552(Ensembl_TRS) KAP2(Synonym)
3393(RGD) Prkar2a(Symbol)
ENSRNOP00000027552(Ensembl_PRO) AC107280(EMBL)
29699(GeneID)
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PANTHER Classification
PANTHER Family: CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN (PTHR11635)
PANTHER Subfamily: CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT (PTHR11635:SF153)  
PANTHER GO-slim Molecular Function: protein kinase binding
protein kinase A binding
protein kinase inhibitor activity
carbohydrate derivative binding
anion binding
nucleotide binding
PANTHER GO-slim Biological Process: regulation of protein serine/threonine kinase activity
negative regulation of protein kinase activity
PANTHER GO-slim Cellular Component: serine/threonine protein kinase complex
intracellular protein-containing complex
cytosol
PANTHER protein class: kinase modulator
Pathway Categories: Metabotropic glutamate receptor group II pathway
   Protein kinase A
GABA-B receptor II signaling
   Protein kinase A
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
   Protein kinase A
Transcription regulation by bZIP transcription factor
   Protein kinase A
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
   Protein kinase A, regulatory subunit
Endothelin signaling pathway
   Protein kinase A
Enkephalin release
   Protein kinase A
Beta1 adrenergic receptor signaling pathway
   Protein kinase A
Hedgehog signaling pathway
   Protein kinase A
Dopamine receptor mediated signaling pathway
   Protein kinase A
5HT1 type receptor mediated signaling pathway
   Protein kinase A
Metabotropic glutamate receptor group III pathway
   Protein kinase A
Histamine H2 receptor mediated signaling pathway
   Protein kinase A
Beta2 adrenergic receptor signaling pathway
   Protein kinase A
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: protein domain specific binding, identical protein binding, protein binding, ubiquitin protein ligase binding, protein kinase A catalytic subunit binding, cAMP binding, small molecule binding, cAMP-dependent protein kinase regulator activity, cAMP-dependent protein kinase inhibitor activity, beta-2 adrenergic receptor binding, protein-containing complex binding
GO BP Complete: negative regulation of cAMP/PKA signal transduction, negative regulation of cAMP-dependent protein kinase activity, regulation of protein kinase activity, positive regulation of meiotic cell cycle process involved in oocyte maturation, modulation of chemical synaptic transmission, adenylate cyclase-activating G protein-coupled receptor signaling pathway, regulation of meiotic cell cycle process involved in oocyte maturation
GO CC Complete: germinal vesicle, synapse, plasma membrane raft, plasma membrane, axoneme, cAMP-dependent protein kinase complex, T-tubule, centrosome, perinuclear region of cytoplasm, cytoplasm, cytosol, protein-containing complex, glutamatergic synapse, nucleotide-activated protein kinase complex
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Signaling by GPCR, Signaling by Hedgehog, Integration of energy metabolism, PKA activation in glucagon signalling, DARPP-32 events, Hemostasis, Neuronal System, Transmission across Chemical Synapses, Neurotransmitter receptors and postsynaptic signal transmission, Opioid Signalling, Factors involved in megakaryocyte development and platelet production, G alpha (i) signalling events, G alpha (s) signalling events, Activation of NMDA receptors and postsynaptic events, Post NMDA receptor activation events, Vasopressin regulates renal water homeostasis via Aquaporins, PKA activation, Glucagon signaling in metabolic regulation, Hedgehog 'off' state, DAG and IP3 signaling, PLC beta mediated events, Signal Transduction, Calmodulin induced events, Ca-dependent events, CaM pathway, PKA-mediated phosphorylation of CREB, Metabolism, GPCR downstream signalling, GPER1 signaling, CREB1 phosphorylation through the activation of Adenylate Cyclase, G-protein mediated events, Intracellular signaling by second messengers, Transport of small molecules, Aquaporin-mediated transport

Orthologs