PANTHER Gene Information

Gene Symbol(s):

Ser

Organism:

Drosophila melanogaster

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Gene Name:

Protein serrate

Gene ID:

FBgn0004197

Protein ID:

P18168

Persistent Id:

PTN000621188

Alternate Ids:

43275(GeneID)	Bd(Synonym)
Ser(Symbol)	45549234(GI)
SERR_DROME(UniProtKB-ID)	FBtr0085128(Ensembl_TRS)
NM_079803(refSeq)	Q9VB65(AltAccession)
CAA40148(EMBL-CDS)	M35759(EMBL)
FBpp0084498(Ensembl_PRO)	FBgn0004197(Ensembl)
FBgn0004197(FlyBase)
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PANTHER Classification

PANTHER Family:	NOTCH LIGAND FAMILY MEMBER (PTHR24044)
PANTHER Subfamily:	PROTEIN JAGGED-2 (PTHR24044:SF421)
PANTHER GO-slim Molecular Function:	signaling receptor binding
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class:	intercellular signal molecule

Pathway Categories:

Notch signaling pathway

Serrate

Notch signaling pathway

Serrate and Notch extracellular fragment

Angiogenesis

Delta

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	glycosphingolipid binding, protein binding, calcium ion binding, Notch binding, receptor ligand activity
GO BP Complete:	imaginal disc-derived leg morphogenesis, larval lymph gland hemopoiesis, cell communication, imaginal disc-derived leg segmentation, imaginal disc-derived wing morphogenesis, imaginal disc-derived wing margin morphogenesis, larval salivary gland morphogenesis, compound eye development, sensory organ development, crystal cell differentiation, salivary gland morphogenesis, wing disc anterior/posterior pattern formation, Notch signaling pathway, germ-line stem cell population maintenance, lateral inhibition, second mitotic wave involved in compound eye morphogenesis, glial cell proliferation, eye-antennal disc development, cuticle pattern formation, negative regulation of lamellocyte differentiation
GO CC Complete:	membrane, axolemma, apical cortex, plasma membrane, apical plasma membrane, cell surface

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Pre-NOTCH Expression and Processing, Negative regulation of NOTCH4 signaling, Pre-NOTCH Processing in Golgi, NOTCH4 Activation and Transmission of Signal to the Nucleus, Signal Transduction, Signaling by NOTCH4, Signaling by NOTCH

Orthologs

ID	Organism	Type
HUMAN\|HGNC=6188\|UniProtKB=P78504	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000013250.5\|UniProtKB=H2QJZ0	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000011017.3\|UniProtKB=G3RXX3	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000018116.4\|UniProtKB=I2CVK6	Macaca mulatta	O
MOUSE\|MGI=MGI=1095416\|UniProtKB=Q9QXX0	Mus musculus	O
RAT\|RGD=2937\|UniProtKB=Q63722	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000012817.6\|UniProtKB=E1BDN7	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000007067.6\|UniProtKB=A0A287A671	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000012993.3\|UniProtKB=F7AKI8	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000002195.6\|UniProtKB=A0A5F5XUV3	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845024085.1\|UniProtKB=A0A8I3Q037	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000004910.3\|UniProtKB=F7C1Q4	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000008425.4\|UniProtKB=F6VUQ4	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010018226.1\|UniProtKB=E1BTW5	Gallus gallus	O
ORYLA\|Ensembl=ENSORLG00000000972.2\|UniProtKB=A0A3B3HLA7	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000012175.2\|UniProtKB=H2M9P8	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-011128-2\|UniProtKB=Q90Y57	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-011128-4\|UniProtKB=Q90Y54	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000015958.1\|UniProtKB=W5NG98	lepisosteus oculatus	O
STRPU\|EnsemblGenome=LOC115921237\|UniProtKB=A0A7M7NCI6	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=GeneID_373299\|UniProtKB=A0A7M6UUZ3	Strongylocentrotus purpuratus	O
HUMAN\|HGNC=6189\|UniProtKB=Q9Y219	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000006784.6\|UniProtKB=A0A2I3SG43	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000007597.3\|UniProtKB=G3QXA1	Gorilla gorilla gorilla	LDO
MOUSE\|MGI=MGI=1098270\|UniProtKB=Q9QYE5	Mus musculus	LDO
RAT\|RGD=2938\|UniProtKB=P97607	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000007319.5\|UniProtKB=G3X6N5	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000002555.6\|UniProtKB=K7GKX0	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000006609.4\|UniProtKB=A0A3Q2I2E7	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000031155.4\|UniProtKB=A0A2I2U449	Felis catus	LDO
MONDO\|Ensembl=ENSMODG00000014707.4\|UniProtKB=F7D3A1	Monodelphis domestica	LDO
CHICK\|Ensembl=ENSGALG00010019830.1\|UniProtKB=A0A8V0ZBK3	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000009394.4\|UniProtKB=G1KJ33	Anolis carolinensis	LDO
ORYLA\|Ensembl=ENSORLG00000017877.2\|UniProtKB=H2MUB9	Oryzias latipes	LDO
DANRE\|Gene=jag2a\|UniProtKB=A0A8N7TDN4	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000010321.1\|UniProtKB=W5MWB8	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000021217.1\|UniProtKB=H2XVU8	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118413944\|UniProtKB=A0A9J7L137	Branchiostoma floridae	O
BRAFL\|Gene=LOC118416040\|UniProtKB=A0A9J7L6H6	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC105443877\|UniProtKB=A0A7M7HNI9	Strongylocentrotus purpuratus	LDO
ANOGA\|EnsemblGenome=AGAP004154\|UniProtKB=A0A1S4GKV6	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC010113\|UniProtKB=D6WSL4	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_49862\|UniProtKB=E9GFT9	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW006939\|UniProtKB=B7PW69	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG161680\|UniProtKB=T1ERS3	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG190982\|UniProtKB=T1FSH0	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g216602\|UniProtKB=A7SS38	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g128497\|UniProtKB=A7SR75	Nematostella vectensis	O
MONBE\|EnsemblGenome=MONBRDRAFT_38707\|UniProtKB=A9V9N1	Monosiga brevicollis	O
GIAIC\|EnsemblGenome=GL50803_24512\|UniProtKB=A8B4D5	Giardia intestinalis	O
CHLRE\|EnsemblGenome=CHLRE_16g690095v5\|UniProtKB=A0A2K3CW78	Chlamydomonas reinhardtii	O