PANTHER Gene Information   
Gene Symbol(s): Galphai
Organism: Drosophila melanogaster
View Gene in Tree
Tree Reduced Tree  
Tree Reduced Tree
Gene Name: G protein alpha i subunit
Gene ID: FBgn0001104
Protein ID: P20353
Persistent Id: PTN000026687
Alternate Ids:
GNAI_DROME(UniProtKB-ID) NP_477502(refSeq)
FBgn0001104(FlyBase) 38765(GeneID)
G-ialpha65A(Synonym) FBpp0076643(Ensembl_PRO)
FBtr0076934(Ensembl_TRS) Galphai(Symbol)
Q9VS04(AltAccession) M23094(EMBL)
FBgn0001104(Ensembl) 15291651(GI)
AAA28565(EMBL-CDS)
Show All

PANTHER Classification
PANTHER Family: GTP-BINDING PROTEIN ALPHA SUBUNIT (PTHR10218)
PANTHER Subfamily: G PROTEIN ALPHA I SUBUNIT (PTHR10218:SF227)  
PANTHER GO-slim Molecular Function: GTPase activity
G protein-coupled receptor binding
protein-containing complex binding
PANTHER GO-slim Biological Process: adenylate cyclase-modulating G protein-coupled receptor signaling pathway
PANTHER GO-slim Cellular Component: plasma membrane protein complex
extrinsic component of membrane
cytoplasm
catalytic complex
cytoplasmic side of plasma membrane
PANTHER protein class: heterotrimeric G-protein
Pathway Categories: Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
   Gi-protein, alpha subunit
5HT1 type receptor mediated signaling pathway
   G-protein
Enkephalin release
   Gi-protein
Opioid proenkephalin pathway
   G-protein
Opioid prodynorphin pathway
   G-protein
PI3 kinase pathway
   G-protein, alpha subunit
Opioid proopiomelanocortin pathway
   G-protein
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
   Gi-protein
Metabotropic glutamate receptor group III pathway
   Gi-protein
Metabotropic glutamate receptor group II pathway
   G-protein

GO MF Complete: GTP binding, G protein-coupled receptor binding, DNA binding, protein binding, GTPase activity, G-protein beta/gamma-subunit complex binding
GO BP Complete: axon ensheathment in central nervous system, G protein-coupled receptor signaling pathway, regulation of protein localization, asymmetric cell division, establishment of spindle orientation, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, establishment of glial blood-brain barrier, cortical actin cytoskeleton organization, ventral cord development, asymmetric protein localization involved in cell fate determination, septate junction assembly, asymmetric neuroblast division, calcium-mediated signaling
GO CC Complete: heterotrimeric G-protein complex, cytoplasm, cell cortex, apical cortex, plasma membrane
Reactome Pathways: Signal amplification, Regulation of insulin secretion, G-protein mediated events, ESR-mediated signaling, G alpha (i) signalling events, Extra-nuclear estrogen signaling, GABA receptor activation, Signal Transduction, GABA B receptor activation, Adenylate cyclase inhibitory pathway, Signaling by GPCR, Platelet activation, signaling and aggregation, Neuronal System, Opioid Signalling, Neurotransmitter receptors and postsynaptic signal transmission, Metabolism, Transmission across Chemical Synapses, Activation of GABAB receptors, Adrenaline,noradrenaline inhibits insulin secretion, Hemostasis, ADP signalling through P2Y purinoceptor 12, Signaling by Nuclear Receptors, Integration of energy metabolism, GPCR downstream signalling