PANTHER Gene Information   
Gene Symbol(s): GNA11
Organism: Homo sapiens
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Gene Name: Guanine nucleotide-binding protein subunit alpha-11
Gene ID: HGNC:4379
Protein ID: P29992
Enhancers: View enhancers for HUMAN|HGNC=4379|UniProtKB=P29992
Genetic Variant Annotation: Annoq
Persistent Id: PTN002469255
Alternate Ids:
119589745(GI) NM_002067(refSeq)
ENST00000078429(Ensembl_TRS) CR457004(EMBL)
Guanine nucleotide-binding protein G(y) subunit alpha(Synonym) GNA11(Symbol)
GNA11_HUMAN(UniProtKB-ID) CAG33285(EMBL-CDS)
CHEMBL4295740(ChEMBL) 615361(MIM)
HGNC:4379(HGNC) ENSP00000078429(Ensembl_PRO)
ENSG00000088256(Ensembl) 2767(GeneID)
O15109(AltAccession)
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PANTHER Classification
PANTHER Family: GTP-BINDING PROTEIN ALPHA SUBUNIT (PTHR10218)
PANTHER Subfamily: GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11 (PTHR10218:SF328)  
PANTHER GO-slim Molecular Function: GTPase activity
G protein-coupled receptor binding
protein-containing complex binding
PANTHER GO-slim Biological Process: adenylate cyclase-modulating G protein-coupled receptor signaling pathway
dopamine receptor signaling pathway
phospholipase C-activating G protein-coupled receptor signaling pathway
PANTHER GO-slim Cellular Component: plasma membrane protein complex
extrinsic component of membrane
cytoplasm
catalytic complex
cytoplasmic side of plasma membrane
PANTHER protein class: heterotrimeric G-protein
Pathway Categories: 5HT2 type receptor mediated signaling pathway
   G-protein
Wnt signaling pathway
   G-protein, alpha subunit
Thyrotropin-releasing hormone receptor signaling pathway
   G-Protein
Histamine H1 receptor mediated signaling pathway
   G-Protein
Inflammation mediated by chemokine and cytokine signaling pathway
   Gi/q-protein, alpha subunit
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
   Gq-protein
Metabotropic glutamate receptor group I pathway
   Gq-protein
PI3 kinase pathway
   G-protein, alpha subunit
Inflammation mediated by chemokine and cytokine signaling pathway
   Gq-protein, alpha subunit
Alpha adrenergic receptor signaling pathway
   G-Protein
Gonadotropin-releasing hormone receptor pathway
   gnaq/11
Cortocotropin releasing factor receptor signaling pathway
   G-Protein
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
   Gq alpha subunit
Endothelin signaling pathway
   guanine nucleotide binding protein q polypeptide
Oxytocin receptor mediated signaling pathway
   G-Protein

GO MF Complete: GTP binding, G protein-coupled receptor binding, protein binding, metal ion binding, GTPase activity, G protein activity, G-protein beta/gamma-subunit complex binding, enzyme regulator activity
GO BP Complete: endothelin receptor signaling pathway, signal transduction, G protein-coupled acetylcholine receptor signaling pathway, cranial skeletal system development, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, phospholipase C-activating dopamine receptor signaling pathway, regulation of blood pressure, regulation of melanocyte differentiation, heart development, developmental pigmentation, phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway, phototransduction, visible light, skeletal system development, entrainment of circadian clock, ion channel modulating, G protein-coupled receptor signaling pathway, action potential, positive regulation of insulin secretion, cellular response to pH, ligand-gated ion channel signaling pathway
GO CC Complete: heterotrimeric G-protein complex, extracellular exosome, cytoplasm, synapse, lysosomal membrane, plasma membrane, photoreceptor outer segment
Reactome Pathways: Free fatty acids regulate insulin secretion, Chaperonin-mediated protein folding, Opioid Signalling, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Acetylcholine regulates insulin secretion, Platelet activation, signaling and aggregation, Protein folding, Signaling by GPCR, G-protein activation, Signal Transduction, G alpha (q) signalling events, Hemostasis, G alpha (i) signalling events, ADP signalling through P2Y purinoceptor 1, Signal amplification, GPCR downstream signalling, Metabolism of proteins, Thromboxane signalling through TP receptor, Thrombin signalling through proteinase activated receptors (PARs), Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion, Metabolism, PLC beta mediated events, Integration of energy metabolism, G-protein mediated events, Regulation of insulin secretion