PANTHER Gene Information

Gene Symbol(s):

lhgD

Organism:

Escherichia coli

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Gene Name:

L-2-hydroxyglutarate dehydrogenase

Gene ID:

BAA16521

Protein ID:

P37339

Persistent Id:

PTN000354499

Alternate Ids:

1.1.5.13 {ECO:0000269\|PubMed:30498244}(EC)	827619436(GI)
WP_000271909(refSeq)	EcoCyc:EG12387-MON(BioCyc)
LHGD_ECOLI(UniProtKB-ID)	P76622(AltAccession)
AAC75707(EMBL-CDS)	b2660(Ensembl)
948069(GeneID)	BAA16521(Ensembl_PRO)
AAC75707(Ensembl_TRS)	M88334(EMBL)
L2HG dehydrogenase {ECO:0000303\|PubMed:30498244}(Synonym)	lhgD{ECO:0000303\|PubMed:30498244}(Symbol)
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PANTHER Classification

PANTHER Family:	L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL (PTHR43104)
PANTHER Subfamily:	L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL (PTHR43104:SF2)
PANTHER GO-slim Molecular Function:	oxidoreductase activity, acting on CH-OH group of donors
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class:	dehydrogenase

Pathway Categories:

Ornithine degradation

Aminobutyraldehyde dehydrogenase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	oxidoreductase activity, acting on CH-OH group of donors, protein binding, oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor, oxidoreductase activity, flavin adenine dinucleotide binding, (S)-2-hydroxyglutarate dehydrogenase activity, 2-hydroxyglutarate dehydrogenase activity
GO BP Complete:	L-lysine catabolic process, lysine catabolic process
GO CC Complete:	cytoplasm, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
MONBE\|EnsemblGenome=MONBRDRAFT_27529\|UniProtKB=A9V5J4	Monosiga brevicollis	O
LEIMA\|EnsemblGenome=LMJF_36_5460\|UniProtKB=Q4Q0L5	Leishmania major	O
TRYB2\|Gene_ORFName=Tb10.6k15.1040\|UniProtKB=Q38A39	Trypanosoma brucei	O
TRIAD\|EnsemblGenome=TriadG58655\|UniProtKB=B3S3B0	Trichoplax adhaerens	O
CANAL\|CGD=CAL0000195713\|UniProtKB=A0A1D8PDW7	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_D04312g\|UniProtKB=Q6CAB3	Yarrowia lipolytica	O
ASPFU\|EnsemblGenome=AFUA_1G04090\|UniProtKB=Q4WK12	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU08048\|UniProtKB=Q7SAJ3	Neurospora crassa	O
SCLS1\|Gene_ORFName=SS1G_09974\|UniProtKB=A7EXB3	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_05922\|UniProtKB=Q0UQP2	Phaeosphaeria nodorum	O
CRYNJ\|EnsemblGenome=CNA06700\|UniProtKB=Q5KNF1	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_05061\|UniProtKB=A0A0D1DXF8	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_16481\|UniProtKB=E3L0X8	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_86688\|UniProtKB=F4NWP8	Batrachochytrium dendrobatidis	O
THAPS\|EnsemblGenome=THAPSDRAFT_20622\|UniProtKB=B8BT38	Thalassiosira pseudonana	O
PHYRM\|Gene=H3G562_PHYRM\|UniProtKB=H3G562	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_13g574150v5\|UniProtKB=A0A2K3CZW2	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00095p00076770\|UniProtKB=W1NU25	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_18G00820\|UniProtKB=A0A0K9PRY8	Zostera marina	O
MUSAM\|EnsemblGenome=Ma11_g18520\|UniProtKB=A0A804L995	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_001617mg\|UniProtKB=K3XI95	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3003G329900\|UniProtKB=C5XN37	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb150290\|UniProtKB=A0A804NBZ7	Zea mays	O
ORYSJ\|EnsemblGenome=Os01g0809900\|UniProtKB=Q5VQP1	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_2g52900v3\|UniProtKB=I1HSN3	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0295840\|UniProtKB=A0A8I6Y295	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS3A02G334600\|UniProtKB=A0A3B6EJZ2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3D02G327900\|UniProtKB=A0A3B6GX56	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G365500\|UniProtKB=A0A3B6FV11	Triticum aestivum	O
NELNU\|Gene_ORFName=HUJ06_001392\|UniProtKB=A0A1U7ZJC4	Nelumbo nucifera	O
SPIOL\|Gene=LOC110799881\|UniProtKB=A0A9R0J410	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr02g0070181\|UniProtKB=A0A251VG55	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C500243720\|UniProtKB=A0A9R1VFX9	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a007006mg\|UniProtKB=A0A022PV24	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_07767\|UniProtKB=A0A2G2ZUM8	Capsicum annuum	O
CAPAN\|EnsemblGenome=T459_26571\|UniProtKB=A0A2G2YNZ1	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400008133\|UniProtKB=M1AEF3	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc10g079440.2\|UniProtKB=A0A3Q7IKY3	Solanum lycopersicum	O
TOBAC\|Gene=LOC107819020\|UniProtKB=A0A1S4CHB0	Nicotiana tabacum	O
TOBAC\|Gene=LOC107788841\|UniProtKB=A0A1S3ZNU8	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi08g02101\|UniProtKB=D7TQ69	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_A02173\|UniProtKB=A0A059DGU9	Eucalyptus grandis	O
BRANA\|Gene_ORFName=DARMORV10_A09P49660.1\|UniProtKB=A0A078GKV4	Brassica napus	O
BRACM\|EnsemblGenome=Bra007275\|UniProtKB=M4CST3	Brassica campestris	O
BRACM\|EnsemblGenome=Bra007273\|UniProtKB=M4CST1	Brassica campestris	O
ARATH\|Gene_OrderedLocusName=At3g56840\|UniProtKB=Q9LES4	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107939016\|UniProtKB=A4L9H4	Gossypium hirsutum	O
GOSHI\|Gene=LOC107922088\|UniProtKB=A4L9I2	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_023913\|UniProtKB=A0A061EVF2	Theobroma cacao	O
POPTR\|EnsemblGenome=POPTR_006G026100v3\|UniProtKB=A0A2K1ZVR6	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_10G072300\|UniProtKB=A0A2C9V456	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_0869370\|UniProtKB=B9SN12	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_05G079900\|UniProtKB=I1K1W2	Glycine max	O
MEDTR\|EnsemblGenome=MTR_6g026730\|UniProtKB=G7KP59	Medicago truncatula	O
JUGRE\|Gene=LOC109007945\|UniProtKB=A0A6P9E804	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_4G416450\|UniProtKB=A0A0A0L0R8	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_7G023400\|UniProtKB=M5W8Z1	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_92593\|UniProtKB=D8RG71	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_271760\|UniProtKB=D8SPM0	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c12_4730\|UniProtKB=A0A2K1JPH3	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0011s0121\|UniProtKB=A0A2R6XK00	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_000790230\|UniProtKB=A0A1Y1HZW3	Klebsormidium nitens	O
HUMAN\|HGNC=20499\|UniProtKB=Q9H9P8	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000006329.5\|UniProtKB=A0A2I3SKZ1	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000003027.3\|UniProtKB=A0A2I2YPQ7	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000007468.4\|UniProtKB=F6SVX9	Macaca mulatta	LDO
MOUSE\|MGI=MGI=2384968\|UniProtKB=Q91YP0	Mus musculus	LDO
RAT\|RGD=1306250\|UniProtKB=D3ZVS2	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000015200\|UniProtKB=A7MBI3	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000005016.5\|UniProtKB=A0A286ZQZ4	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000020354.4\|UniProtKB=A0A9L0R891	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000025658.4\|UniProtKB=A0A337SQN0	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845002841.1\|UniProtKB=A0A8I3RSG8	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000007728.3\|UniProtKB=A0A5F8HDK7	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000013978.3\|UniProtKB=F6USC1	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010019259.1\|UniProtKB=A0A8V0ZGL8	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000001723.3\|UniProtKB=H9G5H9	Anolis carolinensis	LDO
XENLA\|Gene=l2hgdh.L\|UniProtKB=A0A1L8F9P7	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-5764342\|UniProtKB=F6QMX5	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000009117.2\|UniProtKB=H2LZ62	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-090319-6\|UniProtKB=B8A6D3	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000011835.1\|UniProtKB=W5N1P6	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000006381.3\|UniProtKB=F6RKR7	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118425660\|UniProtKB=A0A9J7LZH6	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC578357\|UniProtKB=A0A7M7PR24	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00021564\|UniProtKB=Q9N4Z0	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00028888\|UniProtKB=A8X2R1	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00118584\|UniProtKB=A0A2A6CGH6	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0032729\|UniProtKB=Q9VJ28	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP007868\|UniProtKB=Q7Q3G9	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC007941\|UniProtKB=D2A385	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC007940\|UniProtKB=D2A384	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_305386\|UniProtKB=E9GS31	Daphnia pulex	LDO
HELRO\|EnsemblGenome=HelroG179569\|UniProtKB=T1FEW0	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g172254\|UniProtKB=A7SMW7	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG51164\|UniProtKB=B3SCQ1	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_14006\|UniProtKB=A9UPQ3	Monosiga brevicollis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_28787\|UniProtKB=F4PF51	Batrachochytrium dendrobatidis	LDO
DICDI\|dictyBase=DDB_G0267656\|UniProtKB=Q55GI5	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_33881\|UniProtKB=F0ZLQ4	Dictyostelium purpureum	LDO
PARTE\|EnsemblGenome=GSPATT00031234001\|UniProtKB=A0BR38	Paramecium tetraurelia	LDO
SELML\|EnsemblGenome=SELMODRAFT_88360\|UniProtKB=D8RA38	Selaginella moellendorffii	LDO
SELML\|EnsemblGenome=SELMODRAFT_166561\|UniProtKB=D8QZ22	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c25_9310\|UniProtKB=A0A2K1IEC6	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0085s0100\|UniProtKB=A0A2R6WJ58	Marchantia polymorpha	LDO
NITMS\|EnsemblGenome=Nmar_0409\|UniProtKB=A9A5A6	Nitrosopumilus maritimus	LDO
STRCO\|Gene_OrderedLocusName=SCO4113\|UniProtKB=Q9F303	Streptomyces coelicolor	LDO
GLOVI\|Gene=Q7NIH6_GLOVI\|UniProtKB=Q7NIH6	Gloeobacter violaceus	LDO
SYNY3\|Gene=P74590_SYNY3\|UniProtKB=P74590	Synechocystis	LDO
LEPIN\|EnsemblGenome=LA_1578\|UniProtKB=Q8F5T9	Leptospira interrogans	LDO
RHOBA\|EnsemblGenome=RB10062\|UniProtKB=Q7UKM2	Rhodopirellula baltica	LDO
THEYD\|EnsemblGenome=THEYE_A1961\|UniProtKB=B5YIC0	Thermodesulfovibrio yellowstonii	LDO
HELPY\|EnsemblGenome=HP_0086\|UniProtKB=O24913	Helicobacter pylori	LDO
BRADU\|Gene=Q89E94_BRADU\|UniProtKB=Q89E94	Bradyrhizobium diazoefficiens	LDO
COXBU\|EnsemblGenome=CBU_1839\|UniProtKB=Q83AP2	Coxiella burnetii	LDO
VIBCH\|EnsemblGenome=VC_A0147\|UniProtKB=Q9KN19	Vibrio cholerae	LDO
PSEAE\|EnsemblGenome=PA5418\|UniProtKB=Q9HTE6	Pseudomonas aeruginosa	LDO
SALTY\|EnsemblGenome=STM2790\|UniProtKB=Q8ZMM3	Salmonella typhimurium	LDO