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Gene Symbol(s):
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PIK3CA
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| Organism: |
Homo sapiens |
| View Gene in Tree |
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| Gene Name: |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
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| Gene ID: |
HGNC:8975
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| Protein ID: |
P42336
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| Enhancers: |
View enhancers for HUMAN|HGNC=8975|UniProtKB=P42336 |
| Genetic Variant Annotation: |
Annoq |
| Persistent Id: |
PTN002467587 |
| Alternate Ids: |
| 2.7.1.153 {ECO:0000269|PubMed:15135396, ECO:0000269|PubMed:28676499}(EC) |
675969885(GI) |
| Phosphoinositide-3-kinase catalytic alpha polypeptide(Synonym) |
PIK3CA(Symbol) |
| U79143(EMBL) |
612918(MIM) |
| ENSP00000263967(Ensembl_PRO) |
Q14CW1(AltAccession) |
| ENSG00000121879(Ensembl) |
AAB39753(EMBL-CDS) |
| PK3CA_HUMAN(UniProtKB-ID) |
CHEMBL4005(ChEMBL) |
| MetaCyc:HS04527-MON(BioCyc) |
XP_011511196(refSeq) |
| 5290(GeneID) |
HGNC:8975(HGNC) |
ENST00000263967(Ensembl_TRS) |
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Show All
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| GO MF Complete: |
protein kinase activator activity, 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity, ribosomal protein S6 kinase activity, DNA-dependent protein kinase activity, ATP binding, histone H2AT120 kinase activity, AMP-activated protein kinase activity, histone H3S57 kinase activity, histone H4S1 kinase activity, histone H3S28 kinase activity, histone H3T45 kinase activity, histone H2AXS139 kinase activity, protein serine kinase activity, histone H3S10 kinase activity, histone H2BS14 kinase activity, histone H2AS1 kinase activity, eukaryotic translation initiation factor 2alpha kinase activity, 3-phosphoinositide-dependent protein kinase activity, protein binding, histone H2AS121 kinase activity, histone H3T3 kinase activity, histone H2BS36 kinase activity, insulin receptor substrate binding, Rho-dependent protein serine/threonine kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, histone H3T11 kinase activity, 1-phosphatidylinositol-3-kinase activity, histone H3T6 kinase activity
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| GO BP Complete: |
epidermal growth factor receptor signaling pathway, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol phosphate biosynthetic process, endothelial cell migration, glucose metabolic process, cardiac muscle contraction, cellular response to glucose stimulus, vasculature development, energy homeostasis, response to muscle stretch, positive regulation of TOR signaling, positive regulation of lamellipodium assembly, cardiac muscle cell contraction, response to muscle inactivity, positive regulation of protein localization to membrane, insulin-like growth factor receptor signaling pathway, anoikis, negative regulation of gene expression, phosphatidylinositol-mediated signaling, negative regulation of macroautophagy, response to activity, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of multicellular organism growth, insulin receptor signaling pathway, response to butyrate, response to L-leucine, regulation of actin filament organization, negative regulation of neuron apoptotic process, cellular response to insulin stimulus, positive regulation of smooth muscle cell proliferation, phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of anoikis, angiogenesis, liver development, cell migration, platelet activation, T cell receptor signaling pathway, autosome genomic imprinting, negative regulation of fibroblast apoptotic process, T cell costimulation, vascular endothelial growth factor signaling pathway, regulation of cellular respiration, adipose tissue development, negative regulation of actin filament depolymerization, cellular response to hydrostatic pressure, phagocytosis, actin cytoskeleton organization, relaxation of cardiac muscle, response to dexamethasone
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| GO CC Complete: |
phosphatidylinositol 3-kinase complex, class IA, phosphatidylinositol 3-kinase complex, phosphatidylinositol 3-kinase complex, class IB, perinuclear region of cytoplasm, cytoplasm, cytosol, intercalated disc, plasma membrane, lamellipodium
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| Reactome Pathways: |
Cell-Cell communication, Signaling by ALK in cancer, Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Signaling by ERBB4, Signaling by Rho GTPases, Signaling by FGFR, Downstream TCR signaling, Signaling by NTRKs, Signaling by EGFR, RAC1 GTPase cycle, Signaling by Erythropoietin, Signaling by PDGFRA extracellular domain mutants, Costimulation by the CD28 family, MAPK1/MAPK3 signaling, Role of LAT2/NTAL/LAB on calcium mobilization, Signaling by cytosolic FGFR1 fusion mutants, Metabolism, Activated NTRK3 signals through PI3K, Downstream signal transduction, Signaling by NTRK3 (TRKC), Signaling by MET, Signaling by CSF1 (M-CSF) in myeloid cells, Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants, VEGFA-VEGFR2 Pathway, Signaling by SCF-KIT, PI3K Cascade, PI Metabolism, Constitutive Signaling by EGFRvIII, Signaling by EGFRvIII in Cancer, DAP12 signaling, Signaling by Ligand-Responsive EGFR Variants in Cancer, Interleukin-3, Interleukin-5 and GM-CSF signaling, Phospholipid metabolism, Signaling by KIT in disease, Signaling by VEGF, IRS-mediated signalling, Signaling by GPCR, RHO GTPase cycle, Downstream signaling of activated FGFR3, Innate Immune System, PI3K events in ERBB2 signaling, Signaling by NTRK2 (TRKB), Signaling by ERBB2, CD28 dependent PI3K/Akt signaling, CD28 co-stimulation, Signaling by FGFR in disease, Signaling by FGFR2 in disease, GPCR downstream signalling, Nephrin family interactions, PI3K/AKT activation, GPVI-mediated activation cascade, Signaling by ERBB2 ECD mutants, PI3K events in ERBB4 signaling, Negative regulation of the PI3K/AKT network, Immune System, Signaling by NTRK1 (TRKA), Downstream signaling of activated FGFR4, PI-3K cascade:FGFR3, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants, Signaling by ERBB2 in Cancer, Fc epsilon receptor (FCERI) signaling, MAPK family signaling cascades, MET activates PI3K/AKT signaling, Regulation of signaling by CBL, Platelet activation, signaling and aggregation, Diseases of signal transduction by growth factor receptors and second messengers, G alpha (q) signalling events, PIP3 activates AKT signaling, DAP12 interactions, Signaling by Receptor Tyrosine Kinases, PI-3K cascade:FGFR1, RAF/MAP kinase cascade, Signaling by Nuclear Receptors, Signaling by PDGFR in disease, Downstream signaling of activated FGFR1, PI-3K cascade:FGFR4, Signaling by FLT3 fusion proteins, Tie2 Signaling, Activated NTRK2 signals through PI3K, Signaling by Insulin receptor, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Synthesis of PIPs at the plasma membrane, Insulin receptor signalling cascade, Cell surface interactions at the vascular wall, Signaling by FGFR1, Interleukin-2 family signaling, Signaling by FGFR2, Metabolism of lipids, Axon guidance, PI-3K cascade:FGFR2, Downstream signaling of activated FGFR2, Signaling by FGFR1 in disease, Intracellular signaling by second messengers, PI3K/AKT Signaling in Cancer, Signaling by ERBB2 KD Mutants, Signaling by Interleukins, FGFR1 mutant receptor activation, ESR-mediated signaling, Extra-nuclear estrogen signaling, Signal Transduction, TCR signaling, Fcgamma receptor (FCGR) dependent phagocytosis, Signaling by ALK, IRS-related events triggered by IGF1R, RAC2 GTPase cycle, GAB1 signalosome, Hemostasis, Developmental Biology, IGF1R signaling cascade, Signaling by FGFR4, Constitutive Signaling by Aberrant PI3K in Cancer, Signaling by ALK fusions and activated point mutants, FLT3 signaling in disease, Signaling by PDGF, Role of phospholipids in phagocytosis, Signaling by FGFR3, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants, Signaling by FGFR3 in disease, Signaling by FLT3 ITD and TKD mutants, FLT3 Signaling, Disease, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Signaling by FGFR4 in disease, RET signaling, Cytokine Signaling in Immune system, Interleukin receptor SHC signaling, Adaptive Immune System, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, Signaling by EGFR in Cancer, Nervous system development
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