PANTHER Gene Information   
Gene Symbol(s): GNAQ
Organism: Homo sapiens
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Gene Name: Guanine nucleotide-binding protein G(q) subunit alpha
Gene ID: HGNC:4390
Protein ID: P50148
Enhancers: View enhancers for HUMAN|HGNC=4390|UniProtKB=P50148
Genetic Variant Annotation: Annoq
Persistent Id: PTN002469262
Alternate Ids:
GNAQ_HUMAN(UniProtKB-ID) Q92471(AltAccession)
AAH75096(EMBL-CDS) U43083(EMBL)
GNAQ(Symbol) ENST00000286548(Ensembl_TRS)
CHEMBL3286079(ChEMBL) GAQ(Synonym)
HGNC:4390(HGNC) 2776(GeneID)
163000(MIM) ENSP00000286548(Ensembl_PRO)
251757492(GI) ENSG00000156052(Ensembl)
NP_002063(refSeq)
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PANTHER Classification
PANTHER Family: GTP-BINDING PROTEIN ALPHA SUBUNIT (PTHR10218)
PANTHER Subfamily: GUANINE NUCLEOTIDE-BINDING PROTEIN G(Q) SUBUNIT ALPHA (PTHR10218:SF329)  
PANTHER GO-slim Molecular Function: GTPase activity
G protein-coupled receptor binding
protein-containing complex binding
PANTHER GO-slim Biological Process: adenylate cyclase-modulating G protein-coupled receptor signaling pathway
PANTHER GO-slim Cellular Component: plasma membrane protein complex
extrinsic component of membrane
cytoplasm
catalytic complex
cytoplasmic side of plasma membrane
PANTHER protein class: heterotrimeric G-protein
Pathway Categories: Angiotensin II-stimulated signaling through G proteins and beta-arrestin
   G-protein, alpha q subunit
Wnt signaling pathway
   G-protein, alpha subunit
5HT2 type receptor mediated signaling pathway
   G-protein
Thyrotropin-releasing hormone receptor signaling pathway
   G-Protein
Histamine H1 receptor mediated signaling pathway
   G-Protein
Inflammation mediated by chemokine and cytokine signaling pathway
   Gi/q-protein, alpha subunit
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
   Gq-protein
Metabotropic glutamate receptor group I pathway
   Gq-protein
PI3 kinase pathway
   G-protein, alpha subunit
Inflammation mediated by chemokine and cytokine signaling pathway
   Gq-protein, alpha subunit
Gonadotropin-releasing hormone receptor pathway
   gnaq/11
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
   Gq alpha subunit
Cortocotropin releasing factor receptor signaling pathway
   G-Protein
Endothelin signaling pathway
   guanine nucleotide binding protein q polypeptide
Oxytocin receptor mediated signaling pathway
   G-Protein

GO MF Complete: GTP binding, G protein-coupled receptor binding, protein binding, metal ion binding, GTPase activity, GTPase activator activity, G-protein beta/gamma-subunit complex binding
GO BP Complete: phototransduction, visible light, entrainment of circadian clock, regulation of canonical Wnt signaling pathway, G protein-coupled acetylcholine receptor signaling pathway, action potential, adenylate cyclase-activating G protein-coupled receptor signaling pathway, blood coagulation, protein stabilization, phospholipase C-activating dopamine receptor signaling pathway, negative regulation of protein kinase activity, regulation of platelet activation, glutamate receptor signaling pathway
GO CC Complete: nuclear membrane, heterotrimeric G-protein complex, extracellular exosome, cytoplasm, Golgi apparatus, synapse, lysosomal membrane, plasma membrane, photoreceptor outer segment
Reactome Pathways: Free fatty acids regulate insulin secretion, Chaperonin-mediated protein folding, Opioid Signalling, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Acetylcholine regulates insulin secretion, Platelet activation, signaling and aggregation, Protein folding, Signaling by GPCR, G-protein activation, Signal Transduction, G alpha (q) signalling events, Hemostasis, G alpha (i) signalling events, ADP signalling through P2Y purinoceptor 1, Signal amplification, GPCR downstream signalling, Metabolism of proteins, Thromboxane signalling through TP receptor, Thrombin signalling through proteinase activated receptors (PARs), Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion, Metabolism, PLC beta mediated events, Integration of energy metabolism, G-protein mediated events, Regulation of insulin secretion