PANTHER Gene Information   
Gene Symbol(s): PRKX
Organism: Homo sapiens
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Gene Name: cAMP-dependent protein kinase catalytic subunit PRKX
Gene ID: HGNC:9441
Protein ID: P51817
Enhancers: View enhancers for HUMAN|HGNC=9441|UniProtKB=P51817
Genetic Variant Annotation: Annoq
Persistent Id: PTN002519385
Alternate Ids:
5613(GeneID) PRKX_HUMAN(UniProtKB-ID)
PRKX(Synonym) PRKX(Symbol)
2.7.11.1(EC) AAH41073(EMBL-CDS)
ENSG00000183943(Ensembl) 4826948(GI)
CHEMBL5818(ChEMBL) BC041073(EMBL)
ENSP00000262848(Ensembl_PRO) 300083(MIM)
ENST00000262848(Ensembl_TRS) HGNC:9441(HGNC)
NP_005035(refSeq)
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PANTHER Classification
PANTHER Family: CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE (PTHR24353)
PANTHER Subfamily: CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED (PTHR24353:SF133)  
PANTHER GO-slim Molecular Function: protein serine/threonine kinase activity
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component: cytosol
serine/threonine protein kinase complex
intracellular protein-containing complex
PANTHER protein class: non-receptor serine/threonine protein kinase
Pathway Categories: Metabotropic glutamate receptor group I pathway
   Protein kinase A
Inflammation mediated by chemokine and cytokine signaling pathway
   Protein kinase A
Metabotropic glutamate receptor group II pathway
   Protein kinase A
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
   Protein kinase A
Enkephalin release
   Protein kinase A
Beta1 adrenergic receptor signaling pathway
   Protein kinase A
Dopamine receptor mediated signaling pathway
   Protein kinase A
5HT1 type receptor mediated signaling pathway
   Protein kinase A
Metabotropic glutamate receptor group III pathway
   Protein kinase A
Histamine H2 receptor mediated signaling pathway
   Protein kinase A
Beta2 adrenergic receptor signaling pathway
   Protein kinase A

GO MF Complete: histone H3S10 kinase activity, histone H2BS14 kinase activity, cAMP-dependent protein kinase activity, histone H2AS1 kinase activity, eukaryotic translation initiation factor 2alpha kinase activity, 3-phosphoinositide-dependent protein kinase activity, ribosomal protein S6 kinase activity, DNA-dependent protein kinase activity, ATP binding, histone H2AT120 kinase activity, AMP-activated protein kinase activity, protein binding, histone H2AS121 kinase activity, histone H3S57 kinase activity, histone H4S1 kinase activity, histone H3T3 kinase activity, histone H2BS36 kinase activity, histone H3S28 kinase activity, histone H3T45 kinase activity, histone H2AXS139 kinase activity, Rho-dependent protein serine/threonine kinase activity, histone H3T11 kinase activity, protein serine kinase activity, histone H3T6 kinase activity
GO BP Complete: epithelial tube morphogenesis, kidney morphogenesis, signal transduction, protein autophosphorylation, cell adhesion, endothelial cell migration, chromatin remodeling, angiogenesis, endothelial cell proliferation, myeloid cell differentiation, regulation of cell adhesion, peptidyl-serine phosphorylation, regulation of cell migration, cell-substrate adhesion, regulation of epithelial cell differentiation involved in kidney development
GO CC Complete: nucleus, cytoplasm, cytosol, cAMP-dependent protein kinase complex, nucleoplasm
Reactome Pathways: FCGR3A-mediated IL10 synthesis, Neuronal System, Opioid Signalling, Neurotransmitter receptors and postsynaptic signal transmission, Transmission across Chemical Synapses, Infectious disease, Signaling by GPCR, ADORA2B mediated anti-inflammatory cytokines production, Signal Transduction, Activation of NMDA receptors and postsynaptic events, G alpha (i) signalling events, Post NMDA receptor activation events, GPCR downstream signalling, Leishmania parasite growth and survival, Calmodulin induced events, PKA-mediated phosphorylation of CREB, CaM pathway, Disease, Ca-dependent events, Anti-inflammatory response favouring Leishmania parasite infection, Leishmania infection, DAG and IP3 signaling, PLC beta mediated events, CREB1 phosphorylation through the activation of Adenylate Cyclase, G-protein mediated events, Parasitic Infection Pathways, Intracellular signaling by second messengers