PANTHER Gene Information   
Gene Symbol(s): Gnao1
Organism: Rattus norvegicus
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Gene Name: Guanine nucleotide-binding protein G(o) subunit alpha
Gene ID: 628732
Protein ID: P59215
Persistent Id: PTN000026891
Alternate Ids:
50664(GeneID) CHEMBL4295785(ChEMBL)
ENSRNOG00000019482(Ensembl) 27808491(GI)
M12671(EMBL) 628732(RGD)
GNAO_RAT(UniProtKB-ID) AAA40826(EMBL-CDS)
Gnao(Synonym) P04900(AltAccession)
Gnao1(Symbol)
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PANTHER Classification
PANTHER Family: GTP-BINDING PROTEIN ALPHA SUBUNIT (PTHR10218)
PANTHER Subfamily: GUANINE NUCLEOTIDE-BINDING PROTEIN G(O) SUBUNIT ALPHA (PTHR10218:SF361)  
PANTHER GO-slim Molecular Function: GTPase activity
G protein-coupled receptor binding
protein-containing complex binding
hormone receptor binding
PANTHER GO-slim Biological Process: adenylate cyclase-modulating G protein-coupled receptor signaling pathway
dopamine receptor signaling pathway
PANTHER GO-slim Cellular Component: plasma membrane protein complex
extrinsic component of membrane
cytoplasm
catalytic complex
cytoplasmic side of plasma membrane
PANTHER protein class: heterotrimeric G-protein
Pathway Categories: Endogenous cannabinoid signaling
   Gi/o-protein, alpha subunit
Gonadotropin-releasing hormone receptor pathway
   gnai/o
5HT1 type receptor mediated signaling pathway
   G-protein
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
   Go alpha subunit
Inflammation mediated by chemokine and cytokine signaling pathway
   Gi/q-protein, alpha subunit
Enkephalin release
   Gi-protein
Opioid prodynorphin pathway
   G-protein
Opioid proopiomelanocortin pathway
   G-protein
Inflammation mediated by chemokine and cytokine signaling pathway
   Gi-protein, alpha subunit
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
   Gi-protein
GABA-B receptor II signaling
   G-protein (i/o), alpha subunit
Metabotropic glutamate receptor group II pathway
   G-protein

GO MF Complete: GTP binding, protein binding, metal ion binding, corticotropin-releasing hormone receptor 1 binding, GTPase activity, GDP binding, G-protein beta/gamma-subunit complex binding, GTPase activating protein binding, signaling receptor binding, G protein-coupled serotonin receptor binding, mu-type opioid receptor binding
GO BP Complete: response to cytokine, G protein-coupled receptor signaling pathway, neuron projection development, G protein-coupled dopamine receptor signaling pathway, regulation of heart contraction, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, odontogenesis of dentin-containing tooth, postsynaptic modulation of chemical synaptic transmission, response to xenobiotic stimulus, response to organic cyclic compound, response to hydrogen peroxide, negative regulation of insulin secretion, locomotory behavior, forebrain development, vesicle docking involved in exocytosis, negative regulation of calcium ion transport
GO CC Complete: presynaptic membrane, GABA-ergic synapse, dendrite, heterotrimeric G-protein complex, myelin sheath, cytoplasm, postsynaptic membrane, cell body, parallel fiber to Purkinje cell synapse, synaptic vesicle membrane, glutamatergic synapse, plasma membrane
Reactome Pathways: Ca2+ pathway, Signaling by WNT, Signal Transduction, Beta-catenin independent WNT signaling