PANTHER Gene Information   
Gene Symbol(s): GNAI1
Organism: Homo sapiens
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Gene Name: Guanine nucleotide-binding protein G(i) subunit alpha-1
Gene ID: HGNC:4384
Protein ID: P63096
Enhancers: View enhancers for HUMAN|HGNC=4384|UniProtKB=P63096
Genetic Variant Annotation: Annoq
Persistent Id: PTN002469272
Alternate Ids:
GNAI1_HUMAN(UniProtKB-ID) GNAI1(Synonym)
409973704(GI) A8KA88(AltAccession)
BAF85642(EMBL-CDS) ENSG00000127955(Ensembl)
CHEMBL4741(ChEMBL) M20596(EMBL)
HGNC:4384(HGNC) 619854(MIM)
2770(GeneID)
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PANTHER Classification
PANTHER Family: GTP-BINDING PROTEIN ALPHA SUBUNIT (PTHR10218)
PANTHER Subfamily: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-1 (PTHR10218:SF359)  
PANTHER GO-slim Molecular Function: GTPase activity
G protein-coupled receptor binding
protein-containing complex binding
PANTHER GO-slim Biological Process: adenylate cyclase-modulating G protein-coupled receptor signaling pathway
PANTHER GO-slim Cellular Component: plasma membrane protein complex
extrinsic component of membrane
cytoplasm
catalytic complex
cytoplasmic side of plasma membrane
PANTHER protein class: heterotrimeric G-protein
Pathway Categories: Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
   Gi-protein, alpha subunit
Gonadotropin-releasing hormone receptor pathway
   gnai/o
5HT1 type receptor mediated signaling pathway
   G-protein
Endogenous cannabinoid signaling
   Gi/o-protein, alpha subunit
Enkephalin release
   Gi-protein
Inflammation mediated by chemokine and cytokine signaling pathway
   Gi/q-protein, alpha subunit
Opioid proenkephalin pathway
   G-protein
Opioid prodynorphin pathway
   G-protein
PI3 kinase pathway
   G-protein, alpha subunit
Gonadotropin-releasing hormone receptor pathway
   gnai
Inflammation mediated by chemokine and cytokine signaling pathway
   Gi-protein, alpha subunit
Dopamine receptor mediated signaling pathway
   Gi-protein, alpha subunit
Opioid proopiomelanocortin pathway
   G-protein
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
   Gi-protein
Nicotine pharmacodynamics pathway
   Guanine nuceotide-binding protein, alpha-inhibiting activity polypeptide
Metabotropic glutamate receptor group III pathway
   Gi-protein
Metabotropic glutamate receptor group II pathway
   G-protein
GABA-B receptor II signaling
   G-protein (i/o), alpha subunit

GO MF Complete: magnesium ion binding, GTP binding, G protein-coupled receptor binding, protein binding, GTPase activity, D2 dopamine receptor binding, GDP binding, G-protein beta/gamma-subunit complex binding, G protein-coupled serotonin receptor binding
GO BP Complete: adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, cell division, G protein-coupled receptor signaling pathway, regulation of cAMP-mediated signaling, cellular response to forskolin, positive regulation of protein localization to cell cortex, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, response to peptide hormone, regulation of mitotic spindle organization
GO CC Complete: centrosome, heterotrimeric G-protein complex, extracellular exosome, cytoplasm, cell cortex, midbody, nucleolus, lysosomal membrane, plasma membrane, nucleoplasm
Reactome Pathways: Neuronal System, Opioid Signalling, Neurotransmitter receptors and postsynaptic signal transmission, Transmission across Chemical Synapses, ESR-mediated signaling, Platelet activation, signaling and aggregation, Infectious disease, Extra-nuclear estrogen signaling, Signaling by GPCR, ADORA2B mediated anti-inflammatory cytokines production, GABA receptor activation, Signal Transduction, GABA B receptor activation, G alpha (s) signalling events, Hemostasis, G alpha (z) signalling events, G alpha (i) signalling events, Signal amplification, Signaling by Nuclear Receptors, Adrenaline,noradrenaline inhibits insulin secretion, GPCR downstream signalling, Leishmania parasite growth and survival, Adenylate cyclase inhibitory pathway, Activation of GABAB receptors, ADP signalling through P2Y purinoceptor 12, Disease, Anti-inflammatory response favouring Leishmania parasite infection, Leishmania infection, Metabolism, Integration of energy metabolism, G-protein mediated events, Parasitic Infection Pathways, Regulation of insulin secretion, GPER1 signaling