PANTHER Gene Information

Gene Symbol(s):

Kcnj3

Organism:

Rattus norvegicus

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Gene Name:

G protein-activated inward rectifier potassium channel 1

Gene ID:

2958

Protein ID:

P63251

Persistent Id:

PTN000205714

Alternate Ids:

AAC52127(EMBL-CDS)	U09243(EMBL)
2958(RGD)	CHEMBL3832643(ChEMBL)
50599(GeneID)	ENSRNOP00000082842(Ensembl_PRO)
ENSRNOT00000116585(Ensembl_TRS)	Inward rectifier K(+) channel Kir3.1(Synonym)
KCNJ3_RAT(UniProtKB-ID)	Kcnj3(Symbol)
NP_113798(refSeq)	P35562(AltAccession)
ENSRNOG00000005369(Ensembl)	13928834(GI)
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PANTHER Classification

PANTHER Family:	INWARD RECTIFIER POTASSIUM CHANNEL (PTHR11767)
PANTHER Subfamily:	G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1 (PTHR11767:SF16)
PANTHER GO-slim Molecular Function:	voltage-gated potassium channel activity ligand-gated monoatomic cation channel activity
PANTHER GO-slim Biological Process:	potassium ion import across plasma membrane regulation of monoatomic ion transmembrane transport
PANTHER GO-slim Cellular Component:	plasma membrane
PANTHER protein class:	ion channel

Pathway Categories:

Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway

G-protein receptor kinase

GABA-B receptor II signaling

Inwardly rectifying potassium channel Kir3.1

Muscarinic acetylcholine receptor 2 and 4 signaling pathway

G protein-coupled inwardly rectifying potassium channel

Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway

G protein-activated inward rectifying potassium channel

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	G-protein activated inward rectifier potassium channel activity, phosphatidylinositol-4,5-bisphosphate binding, protein binding, inward rectifier potassium channel activity, voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
GO BP Complete:	potassium ion import across plasma membrane, potassium ion transmembrane transport, regulation of monoatomic ion transmembrane transport, regulation of presynaptic membrane potential, response to electrical stimulus
GO CC Complete:	presynaptic membrane, T-tubule, I(KACh) inward rectifier potassium channel complex, voltage-gated potassium channel complex, parallel fiber to Purkinje cell synapse, external side of plasma membrane, monoatomic ion channel complex, plasma membrane, cell surface

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Potassium Channels, GABA B receptor activation, G protein gated Potassium channels, Activation of GABAB receptors, GABA receptor activation, Inwardly rectifying K+ channels, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, Neuronal System, Transmission across Chemical Synapses, Activation of G protein gated Potassium channels, Neurotransmitter receptors and postsynaptic signal transmission

Orthologs

ID	Organism	Type
HUMAN\|HGNC=6264\|UniProtKB=P48549	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000012547.3\|UniProtKB=H2QIU3	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000022873.2\|UniProtKB=G3SFZ4	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000007096.4\|UniProtKB=F7ERG6	Macaca mulatta	LDO
MOUSE\|MGI=MGI=104742\|UniProtKB=P63250	Mus musculus	LDO
BOVIN\|Ensembl=ENSBTAG00000006159\|UniProtKB=E1BNE9	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000036078.3\|UniProtKB=A0A5G2QUP0	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000001276.3\|UniProtKB=A0A9L0SWA2	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000029250.4\|UniProtKB=M3XFS7	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845025035.1\|UniProtKB=A0A8I3PT84	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000004238.5\|UniProtKB=F6YV60	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000038534.1\|UniProtKB=A0A6I8NVL3	Ornithorhynchus anatinus	LDO
CHICK\|Gene=KCNJ3\|UniProtKB=Q90854	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010010471.1\|UniProtKB=F1NCD3	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000012401.4\|UniProtKB=H9GIV0	Anolis carolinensis	LDO
XENLA\|Gene=kcnj3.L\|UniProtKB=A0A1L8EVZ3	Xenopus laevis	O
XENLA\|Gene=kcnj3.S\|UniProtKB=A0A1L8EP07	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-1004371\|UniProtKB=F6R882	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000016688.2\|UniProtKB=H2MQ61	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-100922-16\|UniProtKB=E7F2Y9	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-120215-38\|UniProtKB=E7F1N1	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000005729.1\|UniProtKB=W5MEV0	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000023776.1\|UniProtKB=F6XQI0	Ciona intestinalis	O
BRAFL\|Gene_ORFName=BRAFLDRAFT_121818\|UniProtKB=C3YD60	Branchiostoma floridae	O
BRAFL\|Gene=LOC118426070\|UniProtKB=A0A9J7N316	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC584140\|UniProtKB=A0A7M7NLD4	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115918598\|UniProtKB=A0A7M7NRA6	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC584158\|UniProtKB=A0A7M7NRN0	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC592565\|UniProtKB=A0A7M7LSG3	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00002151\|UniProtKB=A0A1C3NSK2	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG10649\|UniProtKB=A8XBI7	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00096471\|UniProtKB=A0A2A6B4B2	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00002149\|UniProtKB=P52192	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG10884\|UniProtKB=A8XC74	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00002150\|UniProtKB=A0A1C3NSN6	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG08126\|UniProtKB=A8X5V6	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00203627\|UniProtKB=A0A2A6CGW5	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0032706\|UniProtKB=B7YZX2	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP007818\|UniProtKB=A0A1S4GX11	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP028144\|UniProtKB=A0A1S4HEA1	Anopheles gambiae	O
DROME\|FlyBase=FBgn0039081\|UniProtKB=A0A0B4LHI9	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP001283\|UniProtKB=Q7PX91	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP001284\|UniProtKB=Q7PKL0	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP001281\|UniProtKB=Q7PKK8	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC034483\|UniProtKB=A0A139WBX6	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC006707\|UniProtKB=D6WYJ8	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC033608\|UniProtKB=A0A139WFH2	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC006708\|UniProtKB=D6WYJ9	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC001199\|UniProtKB=D6WAQ3	Tribolium castaneum	O
DROME\|FlyBase=FBgn0265042\|UniProtKB=A0A0B4KH86	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP029806\|UniProtKB=A0A499FWX7	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC006706\|UniProtKB=D6WYJ7	Tribolium castaneum	O
DAPPU\|Gene_ORFName=DAPPUDRAFT_42289\|UniProtKB=E9FXS2	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_311738\|UniProtKB=E9FXS0	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW016219\|UniProtKB=B7P0N6	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG107917\|UniProtKB=T1EED8	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG157415\|UniProtKB=T1EMB1	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG179553\|UniProtKB=T1FEV3	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG122541\|UniProtKB=T1EGU9	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG79786\|UniProtKB=T1G3T3	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG73033\|UniProtKB=T1G190	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG108208\|UniProtKB=T1EEG9	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG82781\|UniProtKB=T1G4W5	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG122071\|UniProtKB=T1EGT8	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG82544\|UniProtKB=T1G4T5	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG122255\|UniProtKB=T1EGU3	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG106279\|UniProtKB=T1EE13	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g52170\|UniProtKB=A7SE20	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g170615\|UniProtKB=A7SH65	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g101684\|UniProtKB=A7S217	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g93919\|UniProtKB=A7RUM3	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG3835\|UniProtKB=B3RMY4	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_25718\|UniProtKB=A9V082	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_24696\|UniProtKB=A9UX72	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_32445\|UniProtKB=A9UZJ5	Monosiga brevicollis	O
LEIMA\|EnsemblGenome=LMJF_09_0480\|UniProtKB=Q4QHX6	Leishmania major	O
TRYB2\|Gene_ORFName=Tb11.01.4330\|UniProtKB=Q382T2	Trypanosoma brucei	O
THAPS\|EnsemblGenome=THAPS_25330\|UniProtKB=B5YLJ0	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_24946\|UniProtKB=B8CCX1	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_21089\|UniProtKB=B8BSL6	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_5256\|UniProtKB=B8C2E6	Thalassiosira pseudonana	O
PHYRM\|Gene=H3HCM1_PHYRM\|UniProtKB=H3HCM1	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_01g035800v5\|UniProtKB=A0A2K3E712	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_06g311650v5\|UniProtKB=A0A2K3DRT3	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_13g591450v5\|UniProtKB=A0A2K3D141	Chlamydomonas reinhardtii	O
PHYPA\|EnsemblGenome=Pp3c15_3810\|UniProtKB=A0A7I3Z5Z2	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c9_4440\|UniProtKB=A0A2K1K204	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0015s0176\|UniProtKB=A0A2R6XH25	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_005570020\|UniProtKB=A0A1Y1II39	Klebsormidium nitens	O