PANTHER Gene Information

Gene Symbol(s):

PF3D7_1324800

Organism:

Plasmodium falciparum

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Gene Name:

Dihydrofolate synthase_folylpolyglutamate synthase

Gene ID:

PF3D7_1324800

Protein ID:

Q8IE69

Persistent Id:

PTN000875681

Alternate Ids:

Q8IE69(Synonym)	814111(GeneID)
CAD52396(EMBL-CDS)	AL844509(EMBL)
124513264(GI)	PF3D7_1324800(Ensembl)
Q8IE69_PLAF7(UniProtKB-ID)	XM_001349952(refSeq)
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PANTHER Classification

PANTHER Family:	FOLYLPOLYGLUTAMATE SYNTHASE-RELATED (PTHR11136)
PANTHER Subfamily:	DIHYDROFOLATE SYNTHETASE-RELATED (PTHR11136:SF0)
PANTHER GO-slim Molecular Function:	ligase activity
PANTHER GO-slim Biological Process:	organonitrogen compound biosynthetic process organic cyclic compound biosynthetic process cellular nitrogen compound biosynthetic process aromatic compound biosynthetic process heterocycle biosynthetic process folic acid-containing compound metabolic process
PANTHER GO-slim Cellular Component:	cytoplasm
PANTHER protein class:	ligase

Pathway Categories:

Tetrahydrofolate biosynthesis

Dihydrofolate synthase

Formyltetrahydrofolate biosynthesis

Dihydrofolate synthase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	tetrahydrofolylpolyglutamate synthase activity, ATP binding, dihydrofolate synthase activity
GO BP Complete:	folic acid-containing compound biosynthetic process
GO CC Complete:	cytoplasm, mitochondrion, cytosol

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
YEAST\|SGD=S000001615\|UniProtKB=P36001	Saccharomyces cerevisiae	O
YEAST\|SGD=S000004719\|UniProtKB=Q12676	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_AEL310C\|UniProtKB=Q758R3	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000182677\|UniProtKB=A0A1D8PQV5	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_A10032g\|UniProtKB=Q6CHD4	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_04384\|UniProtKB=Q5B4Z6	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_4G06740\|UniProtKB=Q4WNS0	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU01337\|UniProtKB=Q1K7T9	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_03715\|UniProtKB=A7EEH5	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_05335\|UniProtKB=Q0USC9	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPAC227.09\|UniProtKB=Q9UTD0	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_00529\|UniProtKB=B6JVW2	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNH02620\|UniProtKB=Q5KCY2	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_10974\|UniProtKB=A0A0D1DPA2	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_17313\|UniProtKB=E3L3B6	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_12454\|UniProtKB=F4P5E3	Batrachochytrium dendrobatidis	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_9534\|UniProtKB=B8CBL4	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3GXU6_PHYRM\|UniProtKB=H3GXU6	Phytophthora ramorum	LDO
CHLAA\|EnsemblGenome=Caur_0436\|UniProtKB=A9WDT0	Chloroflexus aurantiacus	LDO
STRCO\|Gene_OrderedLocusName=SCO2614\|UniProtKB=Q9L1G4	Streptomyces coelicolor	LDO
MYCTU\|Gene_OrderedLocusName=LH57_13380\|UniProtKB=I6Y0R5	Mycobacterium tuberculosis	LDO
CLOBH\|Gene_OrderedLocusName=CBO3163\|UniProtKB=A5I6P2	Clostridium botulinum	LDO
STRR6\|EnsemblGenome=spr0267\|UniProtKB=Q8DR92	Streptococcus pneumoniae	LDO
STRR6\|EnsemblGenome=spr0178\|UniProtKB=Q8DRE0	Streptococcus pneumoniae	O
STAA8\|EnsemblGenome=SAOUHSC_01766\|UniProtKB=Q2FXR9	Staphylococcus aureus	LDO
LISMO\|Gene=folC\|UniProtKB=Q8Y6Y0	Listeria monocytogenes	LDO
BACSU\|EnsemblGenome=BSU_28080\|UniProtKB=Q05865	Bacillus subtilis	LDO
BACCR\|EnsemblGenome=BC_4464\|UniProtKB=Q817R7	Bacillus cereus	LDO
THEMA\|EnsemblGenome=TM_0166\|UniProtKB=Q9WY13	Thermotoga maritima	LDO
DEIRA\|EnsemblGenome=DR_0340\|UniProtKB=Q9RXH3	Deinococcus radiodurans	LDO
GLOVI\|Gene=folC\|UniProtKB=Q7NLP7	Gloeobacter violaceus	LDO
SYNY3\|Gene=folC\|UniProtKB=P73842	Synechocystis	LDO
LEPIN\|EnsemblGenome=LA_0637\|UniProtKB=Q8F8C1	Leptospira interrogans	LDO
BACTN\|EnsemblGenome=BT_1335\|UniProtKB=Q8A839	Bacteroides thetaiotaomicron	LDO
RHOBA\|EnsemblGenome=RB6237\|UniProtKB=Q7UQM1	Rhodopirellula baltica	LDO
AQUAE\|EnsemblGenome=aq_2045\|UniProtKB=O67833	Aquifex aeolicus	LDO
THEYD\|EnsemblGenome=THEYE_A0558\|UniProtKB=B5YJI6	Thermodesulfovibrio yellowstonii	LDO
DICTD\|EnsemblGenome=Dtur_0758\|UniProtKB=B8DZV7	Dictyoglomus turgidum	LDO
FUSNN\|EnsemblGenome=FN1014\|UniProtKB=Q8RES8	Fusobacterium nucleatum	LDO
HELPY\|EnsemblGenome=HP_1545\|UniProtKB=O26070	Helicobacter pylori	LDO
NEIMB\|EnsemblGenome=NMB0693\|UniProtKB=Q9K0C1	Neisseria meningitidis serogroup b	LDO
GEOSL\|EnsemblGenome=GSU2368\|UniProtKB=Q74AI6	Geobacter sulfurreducens	LDO
BRADU\|Gene=folC\|UniProtKB=Q89WE2	Bradyrhizobium diazoefficiens	LDO
COXBU\|EnsemblGenome=CBU_0894\|UniProtKB=Q83D50	Coxiella burnetii	LDO
HAEIN\|EnsemblGenome=HI_1261\|UniProtKB=P43775	Haemophilus influenzae	LDO
SHEON\|Gene_OrderedLocusName=SO_3067\|UniProtKB=Q8ECR5	Shewanella oneidensis	LDO
VIBCH\|EnsemblGenome=VC_1001\|UniProtKB=Q9KTA2	Vibrio cholerae	LDO
XANCP\|EnsemblGenome=XCC0950\|UniProtKB=Q8PC05	Xanthomonas campestris	LDO
PSEAE\|EnsemblGenome=PA3111\|UniProtKB=Q9HZA8	Pseudomonas aeruginosa	LDO
SALTY\|EnsemblGenome=STM2365\|UniProtKB=Q8ZNC0	Salmonella typhimurium	LDO
YERPE\|Gene_OrderedLocusName=YPO2769\|UniProtKB=A0A5P8YIK0	Yersinia pestis	LDO
ECOLI\|EnsemblGenome=BAA16164\|UniProtKB=P08192	Escherichia coli	LDO