PANTHER Gene Information   
Gene Symbol(s): PIK3C3
Organism: Homo sapiens
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Gene Name: Phosphatidylinositol 3-kinase catalytic subunit type 3
Gene ID: HGNC:8974
Protein ID: Q8NEB9
Enhancers: View enhancers for HUMAN|HGNC=8974|UniProtKB=Q8NEB9
Genetic Variant Annotation: Annoq
Persistent Id: PTN002467592
Alternate Ids:
726969084(GI) CHEMBL1075165(ChEMBL)
HGNC:8974(HGNC) Phosphatidylinositol 3-kinase p100 subunit(Synonym)
Z46973(EMBL) 5289(GeneID)
PK3C3_HUMAN(UniProtKB-ID) NM_002647(refSeq)
ENST00000262039(Ensembl_TRS) PIK3C3{ECO:0000312|HGNC:HGNC:8974}(Symbol)
ENSG00000078142(Ensembl) CAA87094(EMBL-CDS)
ENSP00000262039(Ensembl_PRO) Q15134(AltAccession)
2.7.1.137 {ECO:0000269|PubMed:7628435}(EC) 602609(MIM)
MetaCyc:HS01275-MON(BioCyc)
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PANTHER Classification
PANTHER Family: PHOSPHATIDYLINOSITOL KINASE (PTHR10048)
PANTHER Subfamily: PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3 (PTHR10048:SF7)  
PANTHER GO-slim Molecular Function: lipid kinase activity
phosphotransferase activity, alcohol group as acceptor
PANTHER GO-slim Biological Process: autophagosome assembly
phosphatidylinositol phosphate biosynthetic process
endocytosis
intracellular signal transduction
PANTHER GO-slim Cellular Component: phosphatidylinositol 3-kinase complex, class III
peroxisome
endosome
phagophore assembly site
PANTHER protein class: kinase
Pathway Categories: VEGF signaling pathway
   Phosphatidylinositol 3-kinase
T cell activation
   Phosphatidylinositol 3-kinase
Ras Pathway
   Phosphatidylinositol 3-kinase
Hypoxia response via HIF activation
   Phosphatidylinositol 3-kinase
Insulin/IGF pathway-protein kinase B signaling cascade
   Phosphatidylinositol 3-kinase
FGF signaling pathway
   Phosphatidylinositol 3-kinase
Angiogenesis
   Phosphatidylinositol 3-kinase
EGF receptor signaling pathway
   Phosphatidylinositol 3-kinase
Integrin signalling pathway
   Phosphatidylinositol 3-kinase
Endothelin signaling pathway
   Phosphatidylinositol 3-kinase
PDGF signaling pathway
   Phosphatidylinositol 3-kinase
p53 pathway feedback loops 2
   Phosphatidylinositol 3-kinase
p53 pathway
   Phosphatidylinositol 3-kinase
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: phosphatidylinositol kinase activity, ATP binding, protein binding, protein kinase activity, 1-phosphatidylinositol-3-kinase activity
GO BP Complete: protein localization to phagophore assembly site, positive regulation by host of viral genome replication, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol phosphate biosynthetic process, pexophagy, protein targeting to lysosome, endocytosis, cellular response to glucose starvation, autophagosome assembly, cell division, autophagosome maturation, phosphatidylinositol-mediated signaling, synaptic vesicle endocytosis, autophagy, regulation of autophagy, early endosome to late endosome transport, regulation of macroautophagy, regulation of cytokinesis, positive regulation of protein lipidation, macroautophagy
GO CC Complete: phosphatidylinositol 3-kinase complex, class III, type II, phosphatidylinositol 3-kinase complex, class III, type I, phagophore assembly site, phosphatidylinositol 3-kinase complex, class III, late endosome, autolysosome, autophagosome, axoneme, GABA-ergic synapse, peroxisome, endosome, cytoplasm, presynaptic endosome, membrane, cytosol, phagocytic vesicle membrane, postsynaptic endosome, midbody, glutamatergic synapse
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Antigen Presentation: Folding, assembly and peptide loading of class I MHC, PI3K Cascade, Early SARS-CoV-2 Infection Events, PI Metabolism, Translation of Replicase and Assembly of the Replication Transcription Complex, Phospholipid metabolism, RHO GTPases Activate NADPH Oxidases, Signaling by Rho GTPases, Infectious disease, IRS-mediated signalling, Signal Transduction, Innate Immune System, IRS-related events triggered by IGF1R, IGF1R signaling cascade, SARS-CoV-2-host interactions, Signaling by Receptor Tyrosine Kinases, Autophagy, SARS-CoV-1 Infection, SARS-CoV-2 Infection, Synthesis of PIPs at the late endosome membrane, Synthesis of PIPs at the early endosome membrane, Synthesis of PIPs at the Golgi membrane, Disease, RHO GTPase Effectors, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Signaling by Insulin receptor, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Insulin receptor signalling cascade, Metabolism, Toll-like Receptor Cascades, Toll Like Receptor 9 (TLR9) Cascade, Immune System, Adaptive Immune System, Viral Infection Pathways, Metabolism of lipids, Macroautophagy, SARS-CoV Infections, Class I MHC mediated antigen processing & presentation, Translation of Replicase and Assembly of the Replication Transcription Complex, SARS-CoV-2 activates/modulates innate and adaptive immune responses

Orthologs