PANTHER Gene Information   
Gene Symbol(s): Prkar1a
Organism: Mus musculus
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Gene Name: cAMP-dependent protein kinase type I-alpha regulatory subunit
Gene ID: MGI:104878
Protein ID: Q9DBC7
Persistent Id: PTN000180702
Alternate Ids:
BAC25664(EMBL-CDS) NP_001300903(refSeq)
AK145797(EMBL) KAP0(Synonym)
74219016(GI) ENSMUSG00000020612(Ensembl)
Q3UKU7(AltAccession) Prkar1a(Symbol)
19084(GeneID) ENSMUSP00000102288(Ensembl_PRO)
MGI:104878(MGI) KAP0_MOUSE(UniProtKB-ID)
ENSMUST00000106677(Ensembl_TRS)
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PANTHER Classification
PANTHER Family: CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN (PTHR11635)
PANTHER Subfamily: CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT (PTHR11635:SF129)  
PANTHER GO-slim Molecular Function: protein kinase binding
protein kinase A binding
protein kinase inhibitor activity
carbohydrate derivative binding
anion binding
nucleotide binding
PANTHER GO-slim Biological Process: regulation of protein serine/threonine kinase activity
negative regulation of protein kinase activity
PANTHER GO-slim Cellular Component: serine/threonine protein kinase complex
intracellular protein-containing complex
cytosol
PANTHER protein class: kinase modulator
Pathway Categories: Metabotropic glutamate receptor group I pathway
   Protein kinase A
Metabotropic glutamate receptor group II pathway
   Protein kinase A
GABA-B receptor II signaling
   Protein kinase A
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
   Protein kinase A
Transcription regulation by bZIP transcription factor
   Protein kinase A
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
   Protein kinase A, regulatory subunit
Endothelin signaling pathway
   Protein kinase A
Hedgehog signaling pathway
   Protein kinase A
Metabotropic glutamate receptor group III pathway
   Protein kinase A
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: protein domain specific binding, protein binding, ubiquitin protein ligase binding, protein kinase A catalytic subunit binding, cAMP binding, cAMP-dependent protein kinase regulator activity, cAMP-dependent protein kinase inhibitor activity
GO BP Complete: negative regulation of cAMP/PKA signal transduction, sarcomere organization, negative regulation of activated T cell proliferation, adenylate cyclase-activating G protein-coupled receptor signaling pathway, protein phosphorylation, negative regulation of protein kinase activity, cardiac muscle cell proliferation, animal organ morphogenesis, heart development, negative regulation of gene expression, cellular response to glucagon stimulus, mesoderm formation, positive regulation of insulin secretion, mesenchymal cell proliferation
GO CC Complete: sperm head-tail coupling apparatus, multivesicular body, synapse, plasma membrane raft, axoneme, cAMP-dependent protein kinase complex, immunological synapse, centrosome, cytoplasm, cytosol, neuromuscular junction, protein-containing complex, glutamatergic synapse, nucleotide-activated protein kinase complex
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Transport of small molecules, G alpha (i) signalling events, CREB1 phosphorylation through the activation of Adenylate Cyclase, G alpha (s) signalling events, GPCR downstream signalling, Integration of energy metabolism, PKA activation in glucagon signalling, Vasopressin regulates renal water homeostasis via Aquaporins, Signaling by Hedgehog, Post NMDA receptor activation events, Aquaporin-mediated transport, DARPP-32 events, Transmission across Chemical Synapses, Neuronal System, DAG and IP3 signaling, Hedgehog 'off' state, Signaling by GPCR, Opioid Signalling, Neurotransmitter receptors and postsynaptic signal transmission, Signal Transduction, Intracellular signaling by second messengers, G-protein mediated events, Activation of NMDA receptors and postsynaptic events, Glucagon signaling in metabolic regulation, PKA activation, Calmodulin induced events, GPER1 signaling, Ca-dependent events, PKA-mediated phosphorylation of CREB, CaM pathway, Hemostasis, Metabolism, PLC beta mediated events, Factors involved in megakaryocyte development and platelet production

Orthologs