PANTHER Gene Information   
Gene Symbol(s): Pik3cb
Organism: Rattus norvegicus
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Gene Name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Gene ID: 620917
Protein ID: Q9Z1L0
Persistent Id: PTN000005798
Alternate Ids:
PK3CB_RAT(UniProtKB-ID) PI3Kbeta(Synonym)
2.7.11.1 {ECO:0000250|UniProtKB:P42338}(EC) NP_445933(refSeq)
CAA10046(EMBL-CDS) 16758236(GI)
Pik3cb(Symbol) AJ012482(EMBL)
620917(RGD) 85243(GeneID)
CHEMBL3608198(ChEMBL)
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PANTHER Classification
PANTHER Family: PHOSPHATIDYLINOSITOL KINASE (PTHR10048)
PANTHER Subfamily: PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM (PTHR10048:SF33)  
PANTHER GO-slim Molecular Function: lipid kinase activity
phosphotransferase activity, alcohol group as acceptor
PANTHER GO-slim Biological Process: cell migration
phosphatidylinositol phosphate biosynthetic process
phosphatidylinositol 3-kinase/protein kinase B signal transduction
PANTHER GO-slim Cellular Component: phosphatidylinositol 3-kinase complex
plasma membrane
cytoplasm
PANTHER protein class: kinase
Pathway Categories: PI3 kinase pathway
   p110
T cell activation
   Phosphatidylinositol 3-kinase
PI3 kinase pathway
   Activated p110
Ras Pathway
   Phosphatidylinositol 3-kinase
CCKR signaling map
   p110
Insulin/IGF pathway-protein kinase B signaling cascade
   Phosphatidylinositol 3-kinase
Inflammation mediated by chemokine and cytokine signaling pathway
   Phosphatidylinositol 3-kinase
Endothelin signaling pathway
   Phosphatidylinositol 3-kinase
p53 pathway feedback loops 2
   Phosphatidylinositol 3-kinase
p53 pathway
   Phosphatidylinositol 3-kinase
Interleukin signaling pathway
   Phosphatidylinositol 3-kinase
VEGF signaling pathway
   Phosphatidylinositol 3-kinase
Hypoxia response via HIF activation
   Phosphatidylinositol 3-kinase
FGF signaling pathway
   Phosphatidylinositol 3-kinase
Angiogenesis
   Phosphatidylinositol 3-kinase
EGF receptor signaling pathway
   Phosphatidylinositol 3-kinase
Integrin signalling pathway
   Phosphatidylinositol 3-kinase
Axon guidance mediated by netrin
   Phosphatidylinositol 3-kinase
PDGF signaling pathway
   Phosphatidylinositol 3-kinase
Apoptosis signaling pathway
   Phosphatidylinositol 3-kinase
B cell activation
   Phosphatidylinositol 3-kinase
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: ATP binding, insulin receptor substrate binding, 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, protein serine kinase activity, 1-phosphatidylinositol-3-kinase activity
GO BP Complete: positive regulation of Rac protein signal transduction, embryonic cleavage, positive regulation of nitric oxide biosynthetic process, negative regulation of MAPK cascade, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol phosphate biosynthetic process, homophilic cell adhesion via plasma membrane adhesion molecules, sphingosine-1-phosphate receptor signaling pathway, negative regulation of vascular endothelial growth factor signaling pathway, phosphatidylinositol 3-kinase/protein kinase B signal transduction, response to ischemia, autophagy, positive regulation of endothelial cell migration, cell migration, platelet activation, angiogenesis involved in wound healing, negative regulation of sprouting angiogenesis, negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway, positive regulation of neutrophil apoptotic process, natural killer cell mediated cytotoxicity, endocytosis, intracellular calcium ion homeostasis, regulation of cell-matrix adhesion, phosphatidylinositol-mediated signaling, positive regulation of gene expression, endothelial cell proliferation, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO CC Complete: phosphatidylinositol 3-kinase complex, class IA, nucleus, phosphatidylinositol 3-kinase complex, brush border membrane, cytoplasm, intracellular membrane-bounded organelle, cytosol, midbody, nucleolus, plasma membrane, nucleoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: DAP12 signaling, Phospholipid metabolism, Downstream signal transduction, Cell surface interactions at the vascular wall, Signaling by Insulin receptor, Insulin receptor signalling cascade, Fcgamma receptor (FCGR) dependent phagocytosis, Role of phospholipids in phagocytosis, IRS-related events triggered by IGF1R, Role of LAT2/NTAL/LAB on calcium mobilization, Developmental Biology, Signaling by PDGF, GPVI-mediated activation cascade, TCR signaling, Signaling by ALK, Nervous system development, Signaling by NTRKs, PI3K/AKT activation, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, RET signaling, Negative regulation of the PI3K/AKT network, Immune System, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Adaptive Immune System, Cytokine Signaling in Immune system, IRS-mediated signalling, Fc epsilon receptor (FCERI) signaling, VEGFA-VEGFR2 Pathway, Signaling by NTRK1 (TRKA), MAPK family signaling cascades, Hemostasis, Interleukin receptor SHC signaling, Erythropoietin activates Phosphoinositide-3-kinase (PI3K), PIP3 activates AKT signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Signaling by Erythropoietin, Signaling by Interleukins, Platelet activation, signaling and aggregation, Signaling by VEGF, Signaling by Receptor Tyrosine Kinases, Innate Immune System, PI3K Cascade, DAP12 interactions, MAPK1/MAPK3 signaling, Downstream TCR signaling, Signal Transduction, RAF/MAP kinase cascade, IGF1R signaling cascade, Synthesis of PIPs at the plasma membrane, Interleukin-2 family signaling, Axon guidance, Metabolism, Regulation of signaling by CBL, Metabolism of lipids, Intracellular signaling by second messengers, Tie2 Signaling, PI Metabolism

Orthologs