PANTHER Class Information 
| Name: | mediator complex |
| Definition: | A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. |
| Class ID: | GO:0016592 |
| Parent Lineages: |
cellular_component>
cellular anatomical entity>
organelle>
membrane-bounded organelle>
intracellular membrane-bounded organelle>
nucleus>
nuclear protein-containing complex>
mediator complex
cellular_component> cellular anatomical entity> organelle> intracellular organelle> intracellular membrane-bounded organelle> nucleus> nuclear protein-containing complex> mediator complex cellular_component> cellular anatomical entity> intracellular anatomical structure> intracellular organelle> intracellular membrane-bounded organelle> nucleus> nuclear protein-containing complex> mediator complex cellular_component> protein-containing complex> nuclear protein-containing complex> mediator complex |
| Child: | |
| Number Subfamilies/Families: | 118 |
