PANTHER Class Information

Name:	DNA integrity checkpoint signaling
Definition:	A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes.
Class ID:	GO:0031570
Parent Lineages:	biological_process> biological regulation> regulation of biological process> regulation of cellular process> signal transduction> intracellular signal transduction> cell cycle checkpoint signaling> DNA integrity checkpoint signaling biological_process> cellular process> cell communication> signal transduction> intracellular signal transduction> cell cycle checkpoint signaling> DNA integrity checkpoint signaling biological_process> cellular process> signal transduction> intracellular signal transduction> cell cycle checkpoint signaling> DNA integrity checkpoint signaling biological_process> biological regulation> regulation of biological process> signaling> signal transduction> intracellular signal transduction> cell cycle checkpoint signaling> DNA integrity checkpoint signaling biological_process> response to stimulus> cellular response to stimulus> signal transduction> intracellular signal transduction> cell cycle checkpoint signaling> DNA integrity checkpoint signaling biological_process> cellular process> cellular response to stimulus> signal transduction> intracellular signal transduction> cell cycle checkpoint signaling> DNA integrity checkpoint signaling biological_process> biological regulation> regulation of biological process> regulation of cellular process> regulation of cell cycle> regulation of cell cycle process> negative regulation of cell cycle process> negative regulation of cell cycle phase transition> cell cycle checkpoint signaling> DNA integrity checkpoint signaling biological_process> biological regulation> regulation of biological process> negative regulation of biological process> negative regulation of cellular process> negative regulation of cell cycle> negative regulation of cell cycle process> negative regulation of cell cycle phase transition> cell cycle checkpoint signaling> DNA integrity checkpoint signaling biological_process> biological regulation> regulation of biological process> regulation of cellular process> negative regulation of cellular process> negative regulation of cell cycle> negative regulation of cell cycle process> negative regulation of cell cycle phase transition> cell cycle checkpoint signaling> DNA integrity checkpoint signaling biological_process> biological regulation> regulation of biological process> regulation of cellular process> regulation of cell cycle> negative regulation of cell cycle> negative regulation of cell cycle process> negative regulation of cell cycle phase transition> cell cycle checkpoint signaling> DNA integrity checkpoint signaling biological_process> biological regulation> regulation of biological process> regulation of cellular process> regulation of cell cycle> regulation of cell cycle process> regulation of cell cycle phase transition> negative regulation of cell cycle phase transition> cell cycle checkpoint signaling> DNA integrity checkpoint signaling
Child:	DNA damage checkpoint signaling DNA replication checkpoint signaling mitotic DNA integrity checkpoint signaling
Number Subfamilies/Families:	70