Confidence Codes


Code Name Definition
IGI inferred from genetic interaction This evidence code is used in those cases where an annotation is supported by any genetic experiments, such as mutation of a gene product, functional complementation, rescue experiment, etc.
 
IPI inferred from physical interaction This evidence code is used in those cases where an annotation is supported by experiments such as 2-hybrid interaction, co-purification, or co-immunoprecipitation.
 
ISS inferred from sequence similarity This evidence code is used in those cases where an annotation is inferred by sequence similarity, recognized domain, or structural similarity, and the results must be reviewed by curators.
 
IDA inferred from direct assay This evidence code is used in those cases where an annotation is supported by direct assys, including enzyme assays, immunofluorescence, cell fraction, in vitro transcription, or physical interaction/binding assays.
 
IEP inferred from expression pattern This evidence code is used in those cases where an annotation is inferred from the timing or location of expression of a gene.
 
IEA inferred from electronic annotation This evidence code is used in those cases where an annotation is not reviewed by curator and is based on "hits" in sequence similarity, or transfered from database records. It is usually used for annotations directly from computation or automated data transfer.
 
TAS traceable author statement This evidence code is used in those cases where an annotation is based on review articles, textbooks, or dictionaries.
 
NAS non-traceable author statement This evidence code is used in those cases where an annotation is based on statements in papers that a curator can't trace to a publication, or certain database entriesthat don't cute a paper.
 
ND no biological data available This evidence code is used for annotations of "unknown" molecular function or biological process.
 
IC inferred by curator This evidence code is used for those cases where an annotation is not supported by any evidence, but can be reasonably inferred by a curator from other PANTHER annotations, for which evidence is available.
 
IMP inferred from mutant phenotype This evidence code is used for those cases where an annotation is concluded from looking at mutations or abnormal levels of the product(s) only of the gene of interest .
 
RCA inferred from reviewed computational analysis This evidence code is used for those cases where an annotation is based on a non-sequence-based computational method, where the results have been reviewed by an author or a curator
 
EXP Inferred from Experiment null
 
IBA Inferred from Biological aspect of Ancestor null
 
IBD Inferred from Biological aspect of Descendant null
 
IKR Inferred from Key Residues null
 
IRD Inferred from Rapid Divergence null
 
HDA Inferred from High Throughput Direct Assay null
 
HTP Inferred from High Throughput Experiment null
 
HMP Inferred from High Throughput Mutant Phenotype null
 
HGI Inferred from High Throughput Genetic Interaction null
 
HEP Inferred from High Throughput Expression Pattern null
 
TCV Taxon Constraint Violation null