PANTHER Gene Information

Gene Symbol(s):

SHM4

Organism:

Arabidopsis thaliana

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Gene Name:

Serine hydroxymethyltransferase 4

Gene ID:

2129251

Protein ID:

O23254

Persistent Id:

PTN000188200

Alternate Ids:

AAG40343(EMBL-CDS)	11762130(GI)
SHMT4{ECO:0000303\|PubMed:31873125}(Synonym)	AY086929(EMBL)
AT4G13930(Ensembl_TRS)	SHM4{ECO:0000303\|PubMed:10806255}(Symbol)
GLYC4_ARATH(UniProtKB-ID)	NM_117467(refSeq)
2.1.2.1 {ECO:0000269\|PubMed:31873125}(EC)	ARA:AT4G13930-MON(BioCyc)
827027(GeneID)	Q8LBY1(AltAccession)
locus:2129251(TAIR)	AT4G13930(Ensembl_PRO)
AT4G13930(Ensembl)
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PANTHER Classification

PANTHER Family:	SERINE HYDROXYMETHYLTRANSFERASE (PTHR11680)
PANTHER Subfamily:	SERINE HYDROXYMETHYLTRANSFERASE 1 (PTHR11680:SF35)
PANTHER GO-slim Molecular Function:	anion binding heterocyclic compound binding organic cyclic compound binding transferase activity, transferring one-carbon groups
PANTHER GO-slim Biological Process:	proteinogenic amino acid biosynthetic process folic acid-containing compound metabolic process L-amino acid biosynthetic process
PANTHER GO-slim Cellular Component:	cytoplasm
PANTHER protein class:	methyltransferase

Pathway Categories:

Serine glycine biosynthesis

Glycine hydroxymethyltransferase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	pyridoxal phosphate binding, protein binding, glycine hydroxymethyltransferase activity, salicylic acid binding
GO BP Complete:	glycine biosynthetic process from serine, tetrahydrofolate interconversion, tetrahydrofolate metabolic process, circadian rhythm
GO CC Complete:	plasmodesma, cytoplasm, mitochondrion, cytosol, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g129467\|UniProtKB=A7SS63	Nematostella vectensis	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_13528\|UniProtKB=A9UQD9	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_11208\|UniProtKB=A9V8I9	Monosiga brevicollis	LDO
CRYNJ\|EnsemblGenome=CNJ00410\|UniProtKB=Q5KAU8	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_10586\|UniProtKB=A0A0D1CD49	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_05338\|UniProtKB=E3K747	Puccinia graminis	O
PUCGT\|EnsemblGenome=PGTG_09674\|UniProtKB=E3KI36	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_18481\|UniProtKB=F4NRS4	Batrachochytrium dendrobatidis	LDO
DICDI\|dictyBase=DDB_G0291652\|UniProtKB=Q54EW1	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_97107\|UniProtKB=F0ZDZ0	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0277947\|UniProtKB=Q54Z26	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_53574\|UniProtKB=F0ZDH7	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_14_1320\|UniProtKB=Q4QFK2	Leishmania major	O
LEIMA\|EnsemblGenome=LMJF_28_2370\|UniProtKB=Q4Q828	Leishmania major	LDO
TRIV3\|Gene_ORFName=TVAG_109540\|UniProtKB=A2EAE3	Trichomonas vaginalis	LDO
PLAF7\|EnsemblGenome=PF3D7_1456100\|UniProtKB=Q8IKR8	Plasmodium falciparum	O
PLAF7\|EnsemblGenome=PF3D7_1235600\|UniProtKB=Q8I566	Plasmodium falciparum	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_26190\|UniProtKB=B8C1A2	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_26031\|UniProtKB=B8CCS6	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3GN18_PHYRM\|UniProtKB=H3GN18	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_06g293950v5\|UniProtKB=A0A2K3DQH9	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00013p00262120\|UniProtKB=W1PQW2	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_5G02200\|UniProtKB=A0A0K9NUP3	Zostera marina	O
ZOSMR\|Gene_ORFName=ZOSMA_42G00470\|UniProtKB=A0A0K9P1R8	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma08_g00320\|UniProtKB=A0A804K1B4	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma09_g01590\|UniProtKB=A0A804KET4	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma09_g07020\|UniProtKB=A0A804KGU3	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma06_g08130\|UniProtKB=A0A804JDX4	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_021684mg\|UniProtKB=K3Z566	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3008G144800\|UniProtKB=C5YQS6	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb030210\|UniProtKB=A0A1D6KEP0	Zea mays	O
ORYSJ\|EnsemblGenome=Os12g0409000\|UniProtKB=Q2QT32	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_4g08097v3\|UniProtKB=I1IIP2	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.1HG0057870\|UniProtKB=F2CRV8	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS1B02G232200\|UniProtKB=A0A3B5YZ07	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1A02G218700\|UniProtKB=A0A3B5Y1D7	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1D02G220400\|UniProtKB=A0A3B5ZV64	Triticum aestivum	O
SETIT\|EnsemblGenome=SETIT_001011mg\|UniProtKB=K3XGJ1	Setaria italica	O
SETIT\|EnsemblGenome=SETIT_026132mg\|UniProtKB=K3ZHT0	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3005G113300\|UniProtKB=C5Y297	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb170020\|UniProtKB=K7TSD2	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os11g0455800\|UniProtKB=A0A0P0Y248	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_4g19470v3\|UniProtKB=I1ILT7	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.2HG0201400\|UniProtKB=F2DET3	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS2A02G493700\|UniProtKB=A0A1D5UPW5	Triticum aestivum	LDO
WHEAT\|EnsemblGenome=TraesCS2B02G521700\|UniProtKB=A0A3B6CE87	Triticum aestivum	LDO
NELNU\|Gene=LOC104609082\|UniProtKB=A0A1U8AZ14	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110798990\|UniProtKB=A0A9R0J274	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr14g0635091\|UniProtKB=A0A251SFI7	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr15g0704601\|UniProtKB=A0A251SAW2	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C200066860\|UniProtKB=A0A9R1XQ89	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a005792mg\|UniProtKB=A0A022QS28	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_15282\|UniProtKB=A0A2G2ZJS8	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400015745\|UniProtKB=M1BAA6	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc05g053810.3\|UniProtKB=A0A3Q7GNF6	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107761184\|UniProtKB=A0A1S3X4P8	Nicotiana tabacum	O
TOBAC\|Gene=LOC107800464\|UniProtKB=A0A1S4ARC4	Nicotiana tabacum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400004660\|UniProtKB=M1A0B7	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc12g098490.2\|UniProtKB=A0A3Q7JE99	Solanum lycopersicum	O
TOBAC\|Gene=LOC107830241\|UniProtKB=A0A1S4DIW7	Nicotiana tabacum	O
TOBAC\|Gene=LOC107820931\|UniProtKB=A0A1S4CP79	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi05g01091\|UniProtKB=F6GWF3	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_E00610\|UniProtKB=A0A059C1S6	Eucalyptus grandis	O
EUCGR\|EnsemblGenome=EUGRSUZ_E00603\|UniProtKB=A0A059C1A4	Eucalyptus grandis	O
EUCGR\|EnsemblGenome=EUGRSUZ_H02679\|UniProtKB=A0A059B1U0	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=GSBRNA2T00087147001\|UniProtKB=A0A078I8R0	Brassica napus	O
BRACM\|EnsemblGenome=Bra014001\|UniProtKB=M4DBY9	Brassica campestris	O
BRANA\|EnsemblGenome=GSBRNA2T00084232001\|UniProtKB=A0A078JNV3	Brassica napus	O
BRANA\|Gene_ORFName=GSBRNA2T00096661001\|UniProtKB=A0A078IK98	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra032749\|UniProtKB=M4EVB6	Brassica campestris	LDO
GOSHI\|Gene=LOC107943813\|UniProtKB=A0A1U8N245	Gossypium hirsutum	O
GOSHI\|Gene=LOC107890500\|UniProtKB=A0A1U8HWR2	Gossypium hirsutum	O
GOSHI\|Gene=LOC107914785\|UniProtKB=A0A1U8K9W3	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_020228\|UniProtKB=A0A061ES58	Theobroma cacao	LDO
POPTR\|EnsemblGenome=POPTR_017G059300v3\|UniProtKB=B9N0U0	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_001G320400v3\|UniProtKB=A9P855	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_03G144000\|UniProtKB=A0A2C9WA06	Manihot esculenta	O
MANES\|EnsemblGenome=MANES_15G056900\|UniProtKB=A0A2C9UD42	Manihot esculenta	O
MANES\|EnsemblGenome=MANES_15G056800\|UniProtKB=A0A2C9UE67	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_0523510\|UniProtKB=B9S9Y7	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_05G152100\|UniProtKB=C6ZJY6	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_08G108900\|UniProtKB=A0A0R0IUS1	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_3g084310\|UniProtKB=G7JAR7	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_8g081510\|UniProtKB=G7LH57	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr12_08820\|UniProtKB=A0A2I4GXC4	Juglans regia	O
JUGRE\|EnsemblGenome=Jr07_14600\|UniProtKB=A0A2I4GJJ1	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_2G145880\|UniProtKB=A0A0A0LKC8	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_1G165100\|UniProtKB=M5XDY2	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_270660\|UniProtKB=D8RA85	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_166496\|UniProtKB=D8QYX4	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c15_6270\|UniProtKB=A9TQS1	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0096s0018\|UniProtKB=A0A2R6WFN1	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_001330090\|UniProtKB=A0A0U9HJM4	Klebsormidium nitens	LDO
NITMS\|EnsemblGenome=Nmar_1793\|UniProtKB=A9A3Y9	Nitrosopumilus maritimus	LDO
KORCO\|EnsemblGenome=Kcr_0992\|UniProtKB=B1L5K9	Korarchaeum cryptofilum	LDO
SACS2\|EnsemblGenome=SSO0530\|UniProtKB=Q9UWT5	Sulfolobus solfataricus	LDO
PYRAE\|EnsemblGenome=PAE0798\|UniProtKB=Q8ZYF9	Pyrobaculum aerophilum	LDO
METAC\|EnsemblGenome=MA_3520\|UniProtKB=Q8TK94	Methanosarcina acetivorans	LDO
METJA\|EnsemblGenome=MJ_1597\|UniProtKB=Q58992	Methanocaldococcus jannaschii	LDO
HALSA\|EnsemblGenome=VNG_1414G\|UniProtKB=Q9HPY5	Halobacterium salinarum	LDO
THEKO\|EnsemblGenome=TK0528\|UniProtKB=Q5JF06	Thermococcus kodakaraensis	LDO
CHLAA\|EnsemblGenome=Caur_2543\|UniProtKB=A9WI58	Chloroflexus aurantiacus	LDO
STRCO\|Gene_OrderedLocusName=SCO5364\|UniProtKB=Q9K4E0	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO4837\|UniProtKB=Q9KZA9	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO5470\|UniProtKB=O86565	Streptomyces coelicolor	LDO
MYCTU\|Gene_OrderedLocusName=Rv1093\|UniProtKB=P9WGI9	Mycobacterium tuberculosis	O
MYCTU\|Gene_OrderedLocusName=Rv0070c\|UniProtKB=P9WGI7	Mycobacterium tuberculosis	LDO
MYCGE\|EnsemblGenome=MG_394\|UniProtKB=P47634	mycoplasma genitalium	LDO
CLOBH\|Gene_OrderedLocusName=CBO2595\|UniProtKB=A5I526	Clostridium botulinum	LDO
STRR6\|EnsemblGenome=spr0928\|UniProtKB=Q8DPZ0	Streptococcus pneumoniae	LDO
STAA8\|EnsemblGenome=SAOUHSC_02354\|UniProtKB=Q2FWE5	Staphylococcus aureus	LDO
LISMO\|EnsemblGenome=CAD00617\|UniProtKB=Q8Y4B2	Listeria monocytogenes	LDO
BACSU\|EnsemblGenome=BSU_36900\|UniProtKB=P39148	Bacillus subtilis	LDO
BACCR\|EnsemblGenome=BC_5316\|UniProtKB=Q814V2	Bacillus cereus	LDO
THEMA\|EnsemblGenome=TM_0720\|UniProtKB=Q9WZH9	Thermotoga maritima	LDO
DEIRA\|EnsemblGenome=DR_0038\|UniProtKB=Q9RYB2	Deinococcus radiodurans	LDO
GLOVI\|EnsemblGenome=BAC92310\|UniProtKB=Q7ND67	Gloeobacter violaceus	LDO
SYNY3\|EnsemblGenome=BAA17124\|UniProtKB=P77962	Synechocystis	LDO
LEPIN\|EnsemblGenome=LA_1409\|UniProtKB=Q8F6A0	Leptospira interrogans	LDO
BACTN\|EnsemblGenome=BT_0738\|UniProtKB=Q8A9S7	Bacteroides thetaiotaomicron	LDO
CHLTR\|EnsemblGenome=CT_432\|UniProtKB=O84439	Chlamydia trachomatis	LDO
RHOBA\|EnsemblGenome=RB6215\|UniProtKB=Q7UQN2	Rhodopirellula baltica	LDO
AQUAE\|EnsemblGenome=aq_479\|UniProtKB=O66776	Aquifex aeolicus	LDO
THEYD\|EnsemblGenome=THEYE_A1387\|UniProtKB=B5YFZ0	Thermodesulfovibrio yellowstonii	LDO
DICTD\|EnsemblGenome=Dtur_0810\|UniProtKB=B8E008	Dictyoglomus turgidum	LDO
BRADU\|EnsemblGenome=BAC50298\|UniProtKB=P24060	Bradyrhizobium diazoefficiens	LDO
VIBCH\|EnsemblGenome=VC_A0278\|UniProtKB=Q9KMP4	Vibrio cholerae	LDO
HELPY\|EnsemblGenome=HP_0183\|UniProtKB=P56089	Helicobacter pylori	O
NEIMB\|EnsemblGenome=NMB1055\|UniProtKB=P56990	Neisseria meningitidis serogroup b	O
GEOSL\|EnsemblGenome=GSU1607\|UniProtKB=Q74CR5	Geobacter sulfurreducens	O
BRADU\|Gene=glyA\|UniProtKB=Q89HS7	Bradyrhizobium diazoefficiens	O
COXBU\|EnsemblGenome=CBU_1419\|UniProtKB=Q83BT3	Coxiella burnetii	O
HAEIN\|EnsemblGenome=HI_0889\|UniProtKB=P43844	Haemophilus influenzae	O
SHEON\|Gene_OrderedLocusName=SO_3471\|UniProtKB=Q8EBN8	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_0941\|UniProtKB=Q9KTG1	Vibrio cholerae	O
XANCP\|EnsemblGenome=XCC0690\|UniProtKB=Q8PCN4	Xanthomonas campestris	O
PSEAE\|EnsemblGenome=PA5415\|UniProtKB=Q9HTE9	Pseudomonas aeruginosa	O
PSEAE\|EnsemblGenome=PA2444\|UniProtKB=Q9I138	Pseudomonas aeruginosa	O
PSEAE\|EnsemblGenome=PA4602\|UniProtKB=Q9HVI7	Pseudomonas aeruginosa	O
SALTY\|EnsemblGenome=STM2555\|UniProtKB=P0A2E1	Salmonella typhimurium	O
YERPE\|EnsemblGenome=YP_2548\|UniProtKB=Q8ZCR1	Yersinia pestis	O
ECOLI\|EnsemblGenome=BAA16459\|UniProtKB=P0A825	Escherichia coli	O