PANTHER Gene Information

Gene Symbol(s):

SESN2

Organism:

Bos taurus

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Gene Name:

Sestrin-2

Gene ID:

ENSBTAG00000002363

Protein ID:

Q58CN8

Persistent Id:

PTN002287669

Alternate Ids:

SESN2(Synonym)	509863(GeneID)
Q08E69(AltAccession)	NM_001024507(refSeq)
AAI23387(EMBL-CDS)	SESN2_BOVIN(UniProtKB-ID)
BT021909(EMBL)	ENSBTAG00000002363(Ensembl)
1.11.1.- {ECO:0000250\|UniProtKB:P58004}(EC)	146345512(GI)
SESN2{ECO:0000250\|UniProtKB:P58004}(Symbol)
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PANTHER Classification

PANTHER Family:	P53 REGULATED PA26 NUCLEAR PROTEIN SESTRIN (PTHR12474)
PANTHER Subfamily:	SESTRIN-2 (PTHR12474:SF2)
PANTHER GO-slim Molecular Function:	oxidoreductase activity, acting on peroxide as acceptor amino acid binding
PANTHER GO-slim Biological Process:	positive regulation of macroautophagy negative regulation of TORC1 signaling cellular response to oxygen-containing compound cellular response to amino acid starvation cellular response to organonitrogen compound
PANTHER GO-slim Cellular Component:
PANTHER protein class:	peroxidase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	peroxidase activity, L-leucine binding, protein sequestering activity, oxidoreductase activity, acting on peroxide as acceptor, protein-containing complex binding
GO BP Complete:	positive regulation of protein localization to nucleus, positive regulation of macroautophagy, negative regulation of translation in response to endoplasmic reticulum stress, regulation of response to reactive oxygen species, negative regulation of TORC1 signaling, cellular response to leucine starvation, reactive oxygen species metabolic process, cellular response to L-leucine, regulation of protein phosphorylation, negative regulation of cell growth, DNA damage response, signal transduction by p53 class mediator, cellular oxidant detoxification, cellular response to oxidative stress
GO CC Complete:	nucleus, TORC2 complex, cytoplasm, Atg1/ULK1 kinase complex, nucleotide-activated protein kinase complex

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Generic Transcription Pathway, Cellular responses to stimuli, Transcriptional Regulation by TP53, Gene expression (Transcription), Cellular response to chemical stress, TP53 Regulates Metabolic Genes, KEAP1-NFE2L2 pathway, RNA Polymerase II Transcription, Cellular response to starvation, Amino acids regulate mTORC1, Cellular responses to stress

Orthologs

ID	Organism	Type
HUMAN\|HGNC=20746\|UniProtKB=P58004	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000000429.5\|UniProtKB=K7CUM5	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000014485.3\|UniProtKB=G3REY2	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000019993.4\|UniProtKB=F7FNU6	Macaca mulatta	LDO
MOUSE\|MGI=MGI=2651874\|UniProtKB=P58043	Mus musculus	LDO
RAT\|RGD=1566319\|UniProtKB=B2GUV6	Rattus norvegicus	LDO
PIG\|Ensembl=ENSSSCG00000029438.4\|UniProtKB=A0A4X1TPR3	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000001989.4\|UniProtKB=F6Z2X6	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000013396.5\|UniProtKB=A0A5F5XNP8	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845010570.1\|UniProtKB=A0A8I3NDS6	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000010846.4\|UniProtKB=F7ARK8	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000000634.4\|UniProtKB=F7END0	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010016875.1\|UniProtKB=A0A8V0YY05	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000010993.4\|UniProtKB=H9GH47	Anolis carolinensis	LDO
XENLA\|Gene=sesn2.S\|UniProtKB=A0A8J1ME70	Xenopus laevis	O
XENLA\|Gene=sesn2.L\|UniProtKB=Q6NU55	Xenopus laevis	LDO
XENTR\|Gene=sesn2\|UniProtKB=A0A8J1J4K5	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000011116.2\|UniProtKB=H2M654	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-070108-1\|UniProtKB=A0F081	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000005106.1\|UniProtKB=W5MCN8	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000007668.3\|UniProtKB=F6T7E5	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118423082\|UniProtKB=A0A9J7LQS3	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC584902\|UniProtKB=A0A7M7PFI8	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00022279\|UniProtKB=Q9N4D6	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG03915\|UniProtKB=A8WVR0	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00117377\|UniProtKB=A0A2A6BL70	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0034897\|UniProtKB=Q9W1K5	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP007169\|UniProtKB=Q7PTB1	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC003553\|UniProtKB=D6WHQ5	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_200622\|UniProtKB=E9H5P4	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW002773\|UniProtKB=B7P7V9	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG117076\|UniProtKB=T1EGK0	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG185938\|UniProtKB=T1FNG7	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g188161\|UniProtKB=A7SCG7	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG25289\|UniProtKB=B3RYA9	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_1017\|UniProtKB=A9UW02	Monosiga brevicollis	LDO
DICDI\|dictyBase=DDB_G0279427\|UniProtKB=Q54WU6	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_98918\|UniProtKB=F0ZUS8	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_18_0650\|UniProtKB=Q4QDX6	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb10.05.0190\|UniProtKB=Q388Q1	Trypanosoma brucei	LDO
PARTE\|EnsemblGenome=GSPATT00006213001\|UniProtKB=A0C4J8	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00023191001\|UniProtKB=A0E401	Paramecium tetraurelia	LDO
PARTE\|EnsemblGenome=GSPATT00009541001\|UniProtKB=A0CR11	Paramecium tetraurelia	O
PHYRM\|Gene=H3GGE2_PHYRM\|UniProtKB=H3GGE2	Phytophthora ramorum	LDO