PANTHER Gene Information

Gene Symbol(s):

MAN1A2

Organism:

Bos taurus

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Tree

Gene Name:

alpha-1,2-Mannosidase

Gene ID:

ENSBTAG00000003586.6

Protein ID:

A0A3Q1MKX0

Persistent Id:

PTN000201632

Alternate Ids:

ENSBTAP00000072238(Ensembl_PRO)	ENSBTAT00000072527(Ensembl_TRS)
ENSBTAG00000003586(Ensembl)	A0A3Q1MKX0(Synonym)
NM_001206877(refSeq)	332308970(GI)
A0A3Q1MKX0_BOVIN(UniProtKB-ID)	532645(GeneID)
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PANTHER Classification

PANTHER Family:	MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED (PTHR11742)
PANTHER Subfamily:	MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE IB (PTHR11742:SF40)
PANTHER GO-slim Molecular Function:	hydrolase activity, hydrolyzing O-glycosyl compounds
PANTHER GO-slim Biological Process:	carbohydrate derivative catabolic process ERAD pathway protein modification process response to oxygen-containing compound glycoprotein metabolic process
PANTHER GO-slim Cellular Component:	vesicle Golgi membrane endoplasmic reticulum extracellular space
PANTHER protein class:	protein modifying enzyme

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	calcium ion binding, mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO BP Complete:	carbohydrate metabolic process, lung alveolus development, glycoprotein metabolic process, respiratory gaseous exchange by respiratory system, ERAD pathway
GO CC Complete:	Golgi membrane, endoplasmic reticulum

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Post-translational protein modification, Metabolism of proteins, Transport to the Golgi and subsequent modification, Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2, N-glycan trimming and elongation in the cis-Golgi, Asparagine N-linked glycosylation

Orthologs

ID	Organism	Type
HUMAN\|HGNC=6822\|UniProtKB=O60476	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000024134.6\|UniProtKB=H2R1F7	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000014278.3\|UniProtKB=G3REE6	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000047035.2\|UniProtKB=G7MFZ9	Macaca mulatta	LDO
MOUSE\|MGI=MGI=104676\|UniProtKB=P39098	Mus musculus	LDO
RAT\|RGD=1309767\|UniProtKB=D3ZR49	Rattus norvegicus	LDO
PIG\|Ensembl=ENSSSCG00000006730.5\|UniProtKB=A0A480JM90	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000019681.3\|UniProtKB=F7CFR1	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000019000.5\|UniProtKB=M3WPE4	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845029509.1\|UniProtKB=A0A8I3Q6M3	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000005193.4\|UniProtKB=F7DMZ8	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000003066.4\|UniProtKB=F7A7C9	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010023053.1\|UniProtKB=A0A8V0ZR18	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000007808.3\|UniProtKB=H9GD44	Anolis carolinensis	LDO
XENLA\|Gene=MGC130950\|UniProtKB=Q2TAS8	Xenopus laevis	O
XENLA\|Gene=man1a2.L\|UniProtKB=Q6DFL1	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-1010312\|UniProtKB=F6ZWF3	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000008338.2\|UniProtKB=H2LWI2	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-070912-390\|UniProtKB=B0V2X9	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000011087.1\|UniProtKB=W5MZ14	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000003975.3\|UniProtKB=F6ZBI9	Ciona intestinalis	O
BRAFL\|Gene=LOC118422544\|UniProtKB=A0A9J7LNB7	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC581367\|UniProtKB=A0A7M7T3L3	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00008258\|UniProtKB=Q18788	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG23347\|UniProtKB=A8Y450	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00091485\|UniProtKB=A0A2A6C9W9	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00008411\|UniProtKB=P90787	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00032923\|UniProtKB=A8XE83	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00096997\|UniProtKB=A0A2A6BK77	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0051202\|UniProtKB=Q8IMK0	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0259170\|UniProtKB=P53624	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP000558\|UniProtKB=A7USG7	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC031392\|UniProtKB=A0A139WAC4	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_254370\|UniProtKB=E9H706	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_57431\|UniProtKB=E9H239	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_305670\|UniProtKB=E9FX86	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW022061\|UniProtKB=B7QB86	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG87481\|UniProtKB=T1G6Q8	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g112545\|UniProtKB=A7SBV5	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG25880\|UniProtKB=B3RY07	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG25192\|UniProtKB=B3RY16	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_16647\|UniProtKB=A9UY58	Monosiga brevicollis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_21493\|UniProtKB=F4NTG3	Batrachochytrium dendrobatidis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_34989\|UniProtKB=F4P1B1	Batrachochytrium dendrobatidis	O
DICDI\|dictyBase=DDB_G0284391\|UniProtKB=Q54PQ1	Dictyostelium discoideum	O
DICDI\|dictyBase=DDB_G0284395\|UniProtKB=Q54PP9	Dictyostelium discoideum	O
DICDI\|dictyBase=DDB_G0284393\|UniProtKB=Q54PQ0	Dictyostelium discoideum	O
DICDI\|dictyBase=DDB_G0292918\|UniProtKB=Q54CH4	Dictyostelium discoideum	O
DICDI\|dictyBase=DDB_G0268754\|UniProtKB=Q55EU0	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_74722\|UniProtKB=F0Z8J9	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_157585\|UniProtKB=F0ZZH9	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_86464\|UniProtKB=F0ZBS8	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_155265\|UniProtKB=F0ZTI4	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_147471\|UniProtKB=F0Z8K2	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_55071\|UniProtKB=F0ZK85	Dictyostelium purpureum	O
TRIV3\|Gene_ORFName=TVAG_119010\|UniProtKB=A2D748	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_362570\|UniProtKB=A2E635	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_493940\|UniProtKB=A2DQ25	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_440710\|UniProtKB=A2G7V9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_245880\|UniProtKB=A2E4P6	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_367080\|UniProtKB=A2G576	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_229250\|UniProtKB=A2FBR1	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_586830\|UniProtKB=A2GM78	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_316770\|UniProtKB=A2F055	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_307800\|UniProtKB=A2F433	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_104870\|UniProtKB=A2G072	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_379870\|UniProtKB=A2E7L2	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_176070\|UniProtKB=A2G3K0	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_153790\|UniProtKB=A2EPT4	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_410420\|UniProtKB=A2E8K2	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_417940\|UniProtKB=A2EDB4	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_404080\|UniProtKB=A2EGF7	Trichomonas vaginalis	O
THAPS\|EnsemblGenome=THAPSDRAFT_268640\|UniProtKB=B8C1C0	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_34968\|UniProtKB=B8C5N4	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_40232\|UniProtKB=B8C1C1	Thalassiosira pseudonana	O
PHYRM\|Gene=H3G7X2_PHYRM\|UniProtKB=H3G7X2	Phytophthora ramorum	O
AMBTC\|EnsemblGenome=AMTR_s00019p00253350\|UniProtKB=W1PHK0	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_474G00120\|UniProtKB=A0A0K9P280	Zostera marina	O
MUSAM\|EnsemblGenome=Ma04_g12680\|UniProtKB=A0A804IP18	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma02_g06480\|UniProtKB=A0A804HZW5	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_013487mg\|UniProtKB=K3YGW9	Setaria italica	O
SETIT\|EnsemblGenome=SETIT_009718mg\|UniProtKB=K3Y677	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3006G207200\|UniProtKB=C5YFJ2	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb430470\|UniProtKB=K7TW48	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb071480\|UniProtKB=A0A804MAS3	Zea mays	O
ORYSJ\|EnsemblGenome=Os04g0606400\|UniProtKB=A0A0P0WEF7	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_5g20920v3\|UniProtKB=I1J1I4	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.2HG0192630\|UniProtKB=A0A8I6X014	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS2B02G453500\|UniProtKB=A0A3B6CED2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2D02G430000\|UniProtKB=A0A1D5UKE1	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2A02G432100\|UniProtKB=A0A3B6B421	Triticum aestivum	O
NELNU\|Gene_ORFName=HUJ06_004097\|UniProtKB=A0A1U8BAG6	Nelumbo nucifera	O
SPIOL\|Gene=LOC110785566\|UniProtKB=A0A9R0IAU3	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr12g0527981\|UniProtKB=A0A251T2X7	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr10g0457761\|UniProtKB=A0A251TNA4	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C700387060\|UniProtKB=A0A9R1X4R1	Lactuca sativa	O
LACSA\|Gene_ORFName=LSAT_V11C400192630\|UniProtKB=A0A9R1XFS7	Lactuca sativa	O
LACSA\|Gene_ORFName=LSAT_V11C500278530\|UniProtKB=A0A9R1VGB2	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a003772mg\|UniProtKB=A0A022Q257	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_17264\|UniProtKB=A0A2G2ZB37	Capsicum annuum	O
SOLLC\|EnsemblGenome=Solyc06g063260.3\|UniProtKB=A0A3Q7GYA9	Solanum lycopersicum	O
TOBAC\|Gene=LOC107801002\|UniProtKB=A0A1S4ASU3	Nicotiana tabacum	O
TOBAC\|Gene=LOC107770739\|UniProtKB=A0A1S3Y005	Nicotiana tabacum	O
CAPAN\|EnsemblGenome=T459_10961\|UniProtKB=A0A2G3A3P9	Capsicum annuum	O
SOLLC\|EnsemblGenome=Solyc03g123900.3\|UniProtKB=A0A3Q7GMJ6	Solanum lycopersicum	O
TOBAC\|Gene=LOC107823482\|UniProtKB=A0A1S4CWU8	Nicotiana tabacum	O
TOBAC\|Gene=LOC107816107\|UniProtKB=A0A1S4C7P6	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi11g01160\|UniProtKB=F6GXK1	Vitis vinifera	O
THECC\|EnsemblGenome=TCM_039501\|UniProtKB=A0A061GRA8	Theobroma cacao	O
JUGRE\|EnsemblGenome=Jr11_26100\|UniProtKB=A0A2I4FY77	Juglans regia	O
VITVI\|EnsemblGenome=Vitvi09g01332\|UniProtKB=D7SS50	Vitis vinifera	O
VITVI\|EnsemblGenome=Vitvi09g01344\|UniProtKB=D7SS40	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_C00102\|UniProtKB=A0A059CJL3	Eucalyptus grandis	O
POPTR\|EnsemblGenome=POPTR_018G141100v3\|UniProtKB=A0A2K1X0L6	Populus trichocarpa	O
RICCO\|Gene_ORFName=RCOM_1302160\|UniProtKB=B9S090	Ricinus communis	O
PRUPE\|EnsemblGenome=PRUPE_1G073800\|UniProtKB=A0A251QTP3	Prunus persica	O
EUCGR\|EnsemblGenome=EUGRSUZ_F04021\|UniProtKB=A0A059BY46	Eucalyptus grandis	O
BRANA\|Gene_ORFName=GSBRNA2T00051998001\|UniProtKB=A0A078H4T6	Brassica napus	O
BRACM\|EnsemblGenome=Bra001816\|UniProtKB=M4CC86	Brassica campestris	O
BRANA\|Gene_ORFName=DARMORV10_C05P42660.1\|UniProtKB=A0A078IL33	Brassica napus	O
BRANA\|Gene_ORFName=DARMORV10_A05P27560.1\|UniProtKB=A0A078G2Q8	Brassica napus	O
BRACM\|EnsemblGenome=Bra031256\|UniProtKB=M4ER33	Brassica campestris	O
ARATH\|TAIR=locus=2092965\|UniProtKB=Q8H116	Arabidopsis thaliana	O
BRANA\|Gene_ORFName=DARMORV10_C03P90190.1\|UniProtKB=A0A078IVC9	Brassica napus	O
BRANA\|Gene_ORFName=DARMORV10_A08P02650.1\|UniProtKB=A0A078IB71	Brassica napus	O
BRACM\|EnsemblGenome=Bra014291\|UniProtKB=M4DCS4	Brassica campestris	O
BRANA\|Gene_ORFName=DARMORV10_C06P06710.1\|UniProtKB=A0A078IZ23	Brassica napus	O
BRANA\|Gene_ORFName=DARMORV10_A06P02390.1\|UniProtKB=A0A078GDY0	Brassica napus	O
BRACM\|EnsemblGenome=Bra018917\|UniProtKB=M4DQX4	Brassica campestris	O
ARATH\|TAIR=locus=2017597\|UniProtKB=Q9C512	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107920138\|UniProtKB=A0A1U8KRR6	Gossypium hirsutum	O
GOSHI\|Gene=LOC107951043\|UniProtKB=A0A1U8NRF7	Gossypium hirsutum	O
GOSHI\|Gene=LOC107930424\|UniProtKB=A0A1U8LSQ1	Gossypium hirsutum	O
GOSHI\|Gene=LOC107925062\|UniProtKB=A0A1U8L932	Gossypium hirsutum	O
GOSHI\|Gene=LOC107910612\|UniProtKB=A0A1U8JUP6	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_027862\|UniProtKB=A0A061GB31	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g0083001mg\|UniProtKB=A0A067DIL8	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_008G007500v3\|UniProtKB=B9HK55	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_03G080300\|UniProtKB=A0A2C9W5M4	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_0239110\|UniProtKB=B9SQ97	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_13G101200\|UniProtKB=A0A0R0GKX7	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_17G058500\|UniProtKB=K7MK43	Glycine max	O
MEDTR\|EnsemblGenome=MTR_4g127310\|UniProtKB=G7JU96	Medicago truncatula	O
SOYBN\|EnsemblGenome=GLYMA_08G221900\|UniProtKB=Q9SEH8	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_07G020200\|UniProtKB=I1KGP3	Glycine max	O
MEDTR\|EnsemblGenome=MTR_4g008140\|UniProtKB=A0A072UHK5	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr07_10340\|UniProtKB=A0A2I4ELY0	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_7G447810\|UniProtKB=A0A0A0K990	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_3G019700\|UniProtKB=A0A251PTT1	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_132367\|UniProtKB=D8T5H4	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_101351\|UniProtKB=D8RTN8	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_85111\|UniProtKB=D8R3X5	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_89711\|UniProtKB=D8RAI5	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c23_3680\|UniProtKB=A0A2K1II02	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c24_6140\|UniProtKB=A0A2K1IFQ5	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0005s0011\|UniProtKB=A0A2R6XQD6	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_001830240\|UniProtKB=A0A1Y1I864	Klebsormidium nitens	O