PANTHER Gene Information

Gene Symbol(s):

ARHGAP8

Organism:

Bos taurus

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Gene Name:

Rho GTPase activating protein 8

Gene ID:

ENSBTAG00000008858.6

Protein ID:

F1MYQ4

Persistent Id:

PTN000571293

Alternate Ids:

982982769(GI)	XM_005207493(refSeq)
ENSBTAT00000011665(Ensembl_TRS)	104968450(GeneID)
F1MYQ4(Synonym)	ENSBTAP00000011665(Ensembl_PRO)
F1MYQ4_BOVIN(UniProtKB-ID)	ENSBTAG00000008858(Ensembl)
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PANTHER Classification

PANTHER Family:	RHO GTPASE-ACTIVATING PROTEIN 68F (PTHR45808)
PANTHER Subfamily:	RHO GTPASE-ACTIVATING PROTEIN 8 (PTHR45808:SF4)
PANTHER GO-slim Molecular Function:	GTPase activator activity
PANTHER GO-slim Biological Process:	negative regulation of transport negative regulation of cellular process regulation of cellular localization small GTPase-mediated signal transduction regulation of vesicle-mediated transport
PANTHER GO-slim Cellular Component:	cytoplasm
PANTHER protein class:	GTPase-activating protein

Pathway Categories:

VEGF signaling pathway

Cytoskeletal regulation by Rho GTPase

Rho-GTPase-activating proteins

Angiogenesis

PDGF signaling pathway

GTPase-activating protein Rho

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	GTPase activator activity
GO BP Complete:	signal transduction, small GTPase-mediated signal transduction, positive regulation of ERK1 and ERK2 cascade, negative regulation of endocytic recycling
GO CC Complete:	cytoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

RHO GTPase cycle, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signal Transduction, RHOA GTPase cycle, Signaling by Rho GTPases

Orthologs

ID	Organism	Type
HUMAN\|HGNC=677\|UniProtKB=P85298	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000050575.1\|UniProtKB=A0A2I3S205	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000008084.3\|UniProtKB=G3QYH3	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000031000.3\|UniProtKB=F7GAM6	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1920417\|UniProtKB=Q9CXP4	Mus musculus	LDO
RAT\|RGD=1303143\|UniProtKB=Q6AYD8	Rattus norvegicus	LDO
PIG\|Ensembl=ENSSSCG00000000021.5\|UniProtKB=A0A287A8R8	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000017155.4\|UniProtKB=A0A5F5Q2I8	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000014797.6\|UniProtKB=A0A5F5Y6P2	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845011792.1\|UniProtKB=A0A8I3NMH6	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000047596.1\|UniProtKB=A0A5F8HH00	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000010814.4\|UniProtKB=H9H6F4	Monodelphis domestica	LDO
CHICK\|Ensembl=ENSGALG00010013376.1\|UniProtKB=A0A8V0YS21	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000015730.3\|UniProtKB=G1KRN1	Anolis carolinensis	LDO
XENLA\|Gene=arhgap8.L\|UniProtKB=Q6INW3	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-6455435\|UniProtKB=Q28FZ6	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000027028.1\|UniProtKB=A0A3B3IJ03	Oryzias latipes	LDO
LEPOC\|Ensembl=ENSLOCG00000016538.1\|UniProtKB=W5NIG7	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000011599.2\|UniProtKB=F6S1A9	Ciona intestinalis	O
BRAFL\|Gene=LOC118406625\|UniProtKB=A0A9J7HNK6	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC115918720\|UniProtKB=A0A7M7NZ85	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC578539\|UniProtKB=A0A7M7MXJ4	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC586037\|UniProtKB=A0A7M7P4R6	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00012203\|UniProtKB=Q23130	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00025854\|UniProtKB=A8WTA3	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00107985\|UniProtKB=A0A2A6CYE4	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0036257\|UniProtKB=Q9VTU3	Drosophila melanogaster	O
TRICA\|EnsemblGenome=TC002732\|UniProtKB=D6WDQ3	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_304228\|UniProtKB=E9HTS0	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW007913\|UniProtKB=B7PUI4	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG105496\|UniProtKB=T1EDV7	helobdella robusta	O
TRIAD\|EnsemblGenome=TriadG38479\|UniProtKB=B3SBY9	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_28595\|UniProtKB=A9V8M5	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_30838\|UniProtKB=A9UPL0	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_21800\|UniProtKB=A9UNM9	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_27620\|UniProtKB=A9V5T9	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_25134\|UniProtKB=A9UYI3	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_8581\|UniProtKB=A9V0G7	Monosiga brevicollis	O
YEAST\|SGD=S000003737\|UniProtKB=P32525	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_AFR631C\|UniProtKB=Q752E5	Eremothecium gossypii	O
YARLI\|EnsemblGenome=YALI0_B19052g\|UniProtKB=Q6CE28	Yarrowia lipolytica	O
PHANO\|EnsemblGenome=SNOG_04918\|UniProtKB=Q0UTJ6	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPBC354.13\|UniProtKB=O43027	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_00028\|UniProtKB=B6JUV7	Schizosaccharomyces japonicus	O
SCHPO\|PomBase=SPAC1565.02c\|UniProtKB=Q9P3B1	Schizosaccharomyces pombe	O
CRYNJ\|EnsemblGenome=CNK03150\|UniProtKB=Q5K954	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_04656\|UniProtKB=A0A0D1DYK4	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_03447\|UniProtKB=E3JZL6	Puccinia graminis	O
PUCGT\|EnsemblGenome=PGTG_12688\|UniProtKB=E3KRM2	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_84508\|UniProtKB=F4NRY4	Batrachochytrium dendrobatidis	O
ENTH1\|EnsemblGenome=EHI_049300\|UniProtKB=C4LUD2	Entamoeba histolytica	O
ENTH1\|Gene_ORFName=EHI_161950\|UniProtKB=C4M6N8	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=EHI_056130\|UniProtKB=B1N4B4	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_165060\|UniProtKB=C4M1Y8	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_159300\|UniProtKB=C4LX23	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_129360\|UniProtKB=C4M9W9	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=EHI_155690\|UniProtKB=B1N2T0	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=EHI_199570\|UniProtKB=C4M768	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_187110\|UniProtKB=C4LVS8	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=EHI_055340\|UniProtKB=B1N4I0	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_022860\|UniProtKB=C4LUJ9	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_148840\|UniProtKB=C4LT51	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_148980\|UniProtKB=C4LT64	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_087810\|UniProtKB=C4LXW1	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_118240\|UniProtKB=C4LZ06	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_158090\|UniProtKB=C4M2C8	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_146500\|UniProtKB=C4MA06	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=EHI_068310\|UniProtKB=C4LU24	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_052840\|UniProtKB=C4M3S3	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0269496\|UniProtKB=Q55DW9	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_97170\|UniProtKB=F0ZEE5	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0290891\|UniProtKB=Q54FF4	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_95356\|UniProtKB=F0ZVF2	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0288205\|UniProtKB=Q54J98	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_88032\|UniProtKB=F0ZLW9	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_150164\|UniProtKB=F0ZFL8	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0278755\|UniProtKB=Q54XT6	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_85916\|UniProtKB=F0Z875	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0285391\|UniProtKB=Q54ND2	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_86690\|UniProtKB=F0ZDA6	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0274243\|UniProtKB=Q8SSN9	Dictyostelium discoideum	O
DICDI\|dictyBase=DDB_G0272925\|UniProtKB=Q559A0	Dictyostelium discoideum	O
DICDI\|dictyBase=DDB_G0281739\|UniProtKB=Q54TH9	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_154253\|UniProtKB=F0ZQV2	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_153891\|UniProtKB=F0ZQ04	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_159700\|UniProtKB=F1A4S2	Dictyostelium purpureum	O
GIAIC\|EnsemblGenome=GL50803_14608\|UniProtKB=A8B903	Giardia intestinalis	O
TRIV3\|Gene_ORFName=TVAG_013310\|UniProtKB=A2DD87	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_473760\|UniProtKB=A2EQ22	Trichomonas vaginalis	O
PLAF7\|EnsemblGenome=PF3D7_1007200\|UniProtKB=Q8IJX0	Plasmodium falciparum	O
PARTE\|EnsemblGenome=GSPATT00004975001\|UniProtKB=A0BJ85	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00017102001\|UniProtKB=A0DI64	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00026374001\|UniProtKB=A0EFG0	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00031766001\|UniProtKB=A0BSL7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00035235001\|UniProtKB=A0C5N9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00031602001\|UniProtKB=A0BS54	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00015024001\|UniProtKB=A0DAQ0	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00030662001\|UniProtKB=A0BNA7	Paramecium tetraurelia	O