PANTHER Gene Information

Gene Symbol(s):

RhoGAP68F

Organism:

Drosophila melanogaster

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Gene Name:

Rho GTPase-activating protein 68F

Gene ID:

FBgn0036257

Protein ID:

Q9VTU3

Persistent Id:

PTN000571373

Alternate Ids:

FBgn0036257(Ensembl)	74870902(GI)
AE014296(EMBL)	AAL39456(EMBL-CDS)
RhoGAP68F(Symbol)	FBtr0075997(Ensembl_TRS)
FBgn0036257(FlyBase)	FBpp0075729(Ensembl_PRO)
RG68F(Synonym)	39385(GeneID)
NP_001261744(refSeq)	RG68F_DROME(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	RHO GTPASE-ACTIVATING PROTEIN 68F (PTHR45808)
PANTHER Subfamily:	RHO GTPASE-ACTIVATING PROTEIN 68F (PTHR45808:SF2)
PANTHER GO-slim Molecular Function:	GTPase activator activity
PANTHER GO-slim Biological Process:	small GTPase-mediated signal transduction
PANTHER GO-slim Cellular Component:	cytoplasm
PANTHER protein class:	GTPase-activating protein

Pathway Categories:

VEGF signaling pathway

Cytoskeletal regulation by Rho GTPase

Rho-GTPase-activating proteins

Angiogenesis

PDGF signaling pathway

GTPase-activating protein Rho

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	GTPase activator activity, small GTPase binding
GO BP Complete:	ventral furrow formation, imaginal disc-derived leg morphogenesis, negative regulation of stress fiber assembly, signal transduction, small GTPase-mediated signal transduction, Rho protein signal transduction, positive regulation of synaptic assembly at neuromuscular junction, negative regulation of endocytic recycling
GO CC Complete:	early endosome, cytoplasm, recycling endosome

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Signaling by Rho GTPases, Signal Transduction, RHOB GTPase cycle, RHOF GTPase cycle, RHO GTPase cycle, RHOQ GTPase cycle, RHOD GTPase cycle, RHOG GTPase cycle, RAC1 GTPase cycle, RAC3 GTPase cycle, CDC42 GTPase cycle, RHOA GTPase cycle, RAC2 GTPase cycle, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, RHOJ GTPase cycle

Orthologs

ID	Organism	Type
HUMAN\|HGNC=677\|UniProtKB=P85298	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000050575.1\|UniProtKB=A0A2I3S205	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000008084.3\|UniProtKB=G3QYH3	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000031000.3\|UniProtKB=F7GAM6	Macaca mulatta	O
MOUSE\|MGI=MGI=1920417\|UniProtKB=Q9CXP4	Mus musculus	O
RAT\|RGD=1303143\|UniProtKB=Q6AYD8	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000008858.6\|UniProtKB=F1MYQ4	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000000021.5\|UniProtKB=A0A287A8R8	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000017155.4\|UniProtKB=A0A5F5Q2I8	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000014797.6\|UniProtKB=A0A5F5Y6P2	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845011792.1\|UniProtKB=A0A8I3NMH6	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000047596.1\|UniProtKB=A0A5F8HH00	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000010814.4\|UniProtKB=H9H6F4	Monodelphis domestica	O
CHICK\|Ensembl=ENSGALG00010013376.1\|UniProtKB=A0A8V0YS21	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000015730.3\|UniProtKB=G1KRN1	Anolis carolinensis	O
XENLA\|Gene=arhgap8.L\|UniProtKB=Q6INW3	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-6455435\|UniProtKB=Q28FZ6	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000027028.1\|UniProtKB=A0A3B3IJ03	Oryzias latipes	O
LEPOC\|Ensembl=ENSLOCG00000016538.1\|UniProtKB=W5NIG7	lepisosteus oculatus	O
HUMAN\|HGNC=673\|UniProtKB=Q07960	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000003550.5\|UniProtKB=H2Q3I0	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000005697.3\|UniProtKB=G3RT66	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000007831.4\|UniProtKB=H9Z8U5	Macaca mulatta	LDO
MOUSE\|MGI=MGI=2445003\|UniProtKB=Q5FWK3	Mus musculus	LDO
RAT\|RGD=1306068\|UniProtKB=A0A0G2JYR5	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000016501.6\|UniProtKB=F6RWK1	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000013256.5\|UniProtKB=A0A5G2QDJ1	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000009844.4\|UniProtKB=A0A9L0R1P2	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000013638.5\|UniProtKB=A0A2I2UJ77	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845027069.1\|UniProtKB=A0A8I3PTG9	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000019894.4\|UniProtKB=F6W5V4	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000002770.4\|UniProtKB=F7E0G2	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010022997.1\|UniProtKB=A0A8V0ZKK5	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000003876.4\|UniProtKB=A0A803TY03	Anolis carolinensis	LDO
XENLA\|Gene=arhgap1.L\|UniProtKB=Q7ZXQ7	Xenopus laevis	O
XENLA\|Gene=arhgap1.S\|UniProtKB=Q6DFK3	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-1015089\|UniProtKB=Q66IH1	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000026748.1\|UniProtKB=A0A3B3HAD5	Oryzias latipes	O
DANRE\|Gene=si=dkey-11e23.9\|UniProtKB=A0A8M3AWM4	Danio rerio	O
DANRE\|Gene=LOC110439055\|UniProtKB=A0A8M9Q740	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000019363.2\|UniProtKB=H2MYL7	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-050417-305\|UniProtKB=Q568D8	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000005713.1\|UniProtKB=W5MEU0	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000011599.2\|UniProtKB=F6S1A9	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118406625\|UniProtKB=A0A9J7HNK6	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC115918720\|UniProtKB=A0A7M7NZ85	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC578539\|UniProtKB=A0A7M7MXJ4	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC586037\|UniProtKB=A0A7M7P4R6	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00012203\|UniProtKB=Q23130	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00025854\|UniProtKB=A8WTA3	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00107985\|UniProtKB=A0A2A6CYE4	Pristionchus pacificus	LDO
TRICA\|EnsemblGenome=TC002732\|UniProtKB=D6WDQ3	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_304228\|UniProtKB=E9HTS0	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW007913\|UniProtKB=B7PUI4	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG105496\|UniProtKB=T1EDV7	helobdella robusta	LDO
TRIAD\|EnsemblGenome=TriadG38479\|UniProtKB=B3SBY9	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_28595\|UniProtKB=A9V8M5	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_30838\|UniProtKB=A9UPL0	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_21800\|UniProtKB=A9UNM9	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_27620\|UniProtKB=A9V5T9	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_25134\|UniProtKB=A9UYI3	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_8581\|UniProtKB=A9V0G7	Monosiga brevicollis	LDO
YEAST\|SGD=S000003737\|UniProtKB=P32525	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_AFR631C\|UniProtKB=Q752E5	Eremothecium gossypii	LDO
YARLI\|EnsemblGenome=YALI0_B19052g\|UniProtKB=Q6CE28	Yarrowia lipolytica	LDO
PHANO\|EnsemblGenome=SNOG_04918\|UniProtKB=Q0UTJ6	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPBC354.13\|UniProtKB=O43027	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_00028\|UniProtKB=B6JUV7	Schizosaccharomyces japonicus	LDO
SCHPO\|PomBase=SPAC1565.02c\|UniProtKB=Q9P3B1	Schizosaccharomyces pombe	O
CRYNJ\|EnsemblGenome=CNK03150\|UniProtKB=Q5K954	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_04656\|UniProtKB=A0A0D1DYK4	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_03447\|UniProtKB=E3JZL6	Puccinia graminis	O
PUCGT\|EnsemblGenome=PGTG_12688\|UniProtKB=E3KRM2	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_84508\|UniProtKB=F4NRY4	Batrachochytrium dendrobatidis	LDO
ENTH1\|EnsemblGenome=EHI_049300\|UniProtKB=C4LUD2	Entamoeba histolytica	O
ENTH1\|Gene_ORFName=EHI_161950\|UniProtKB=C4M6N8	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=EHI_056130\|UniProtKB=B1N4B4	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_165060\|UniProtKB=C4M1Y8	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_159300\|UniProtKB=C4LX23	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_129360\|UniProtKB=C4M9W9	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=EHI_155690\|UniProtKB=B1N2T0	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=EHI_199570\|UniProtKB=C4M768	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_187110\|UniProtKB=C4LVS8	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=EHI_055340\|UniProtKB=B1N4I0	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_022860\|UniProtKB=C4LUJ9	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_148840\|UniProtKB=C4LT51	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_148980\|UniProtKB=C4LT64	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_087810\|UniProtKB=C4LXW1	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_118240\|UniProtKB=C4LZ06	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_158090\|UniProtKB=C4M2C8	Entamoeba histolytica	LDO
ENTH1\|EnsemblGenome=CL6EHI_146500\|UniProtKB=C4MA06	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=EHI_068310\|UniProtKB=C4LU24	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_052840\|UniProtKB=C4M3S3	Entamoeba histolytica	LDO
DICDI\|dictyBase=DDB_G0269496\|UniProtKB=Q55DW9	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_97170\|UniProtKB=F0ZEE5	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0290891\|UniProtKB=Q54FF4	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_95356\|UniProtKB=F0ZVF2	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0288205\|UniProtKB=Q54J98	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_88032\|UniProtKB=F0ZLW9	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_150164\|UniProtKB=F0ZFL8	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0278755\|UniProtKB=Q54XT6	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_85916\|UniProtKB=F0Z875	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0285391\|UniProtKB=Q54ND2	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_86690\|UniProtKB=F0ZDA6	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0274243\|UniProtKB=Q8SSN9	Dictyostelium discoideum	O
DICDI\|dictyBase=DDB_G0272925\|UniProtKB=Q559A0	Dictyostelium discoideum	O
DICDI\|dictyBase=DDB_G0281739\|UniProtKB=Q54TH9	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_154253\|UniProtKB=F0ZQV2	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_153891\|UniProtKB=F0ZQ04	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_159700\|UniProtKB=F1A4S2	Dictyostelium purpureum	LDO
GIAIC\|EnsemblGenome=GL50803_14608\|UniProtKB=A8B903	Giardia intestinalis	LDO
TRIV3\|Gene_ORFName=TVAG_013310\|UniProtKB=A2DD87	Trichomonas vaginalis	LDO
TRIV3\|Gene_ORFName=TVAG_473760\|UniProtKB=A2EQ22	Trichomonas vaginalis	O
PLAF7\|EnsemblGenome=PF3D7_1007200\|UniProtKB=Q8IJX0	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00004975001\|UniProtKB=A0BJ85	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00017102001\|UniProtKB=A0DI64	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00026374001\|UniProtKB=A0EFG0	Paramecium tetraurelia	LDO
PARTE\|EnsemblGenome=GSPATT00031766001\|UniProtKB=A0BSL7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00035235001\|UniProtKB=A0C5N9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00031602001\|UniProtKB=A0BS54	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00015024001\|UniProtKB=A0DAQ0	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00030662001\|UniProtKB=A0BNA7	Paramecium tetraurelia	O