PANTHER Gene Information

Gene Symbol(s):

PFKL

Organism:

Bos taurus

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Gene Name:

ATP-dependent 6-phosphofructokinase, liver type

Gene ID:

ENSBTAG00000010658

Protein ID:

A1A4J1

Persistent Id:

PTN000344263

Alternate Ids:

508683(GeneID)	Phosphofructo-1-kinase isozyme B(Synonym)
ENSBTAP00000051545(Ensembl_PRO)	122692503(GI)
NP_001073713(refSeq)	PFKAL_BOVIN(UniProtKB-ID)
ENSBTAG00000010658(Ensembl)	ENSBTAT00000056305(Ensembl_TRS)
2.7.1.11 {ECO:0000255\|HAMAP-Rule:MF_03184}(EC)	PFKL(Symbol)
BC126578(EMBL)	AAI26579(EMBL-CDS)
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PANTHER Classification

PANTHER Family:	PHOSPHOFRUCTOKINASE (PTHR13697)
PANTHER Subfamily:	ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, LIVER TYPE (PTHR13697:SF14)
PANTHER GO-slim Molecular Function:	identical protein binding cation binding ATP binding phosphotransferase activity, alcohol group as acceptor carbohydrate kinase activity monosaccharide binding
PANTHER GO-slim Biological Process:	small molecule catabolic process glucose metabolic process glycolytic process
PANTHER GO-slim Cellular Component:	transferase complex, transferring phosphorus-containing groups membrane cytosol
PANTHER protein class:	carbohydrate kinase

Pathway Categories:

Glycolysis

Phosphofructokinase-1

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	ATP binding, identical protein binding, fructose binding, fructose-6-phosphate binding, metal ion binding, 6-phosphofructokinase activity, kinase binding
GO BP Complete:	response to glucose, glycolytic process, fructose 6-phosphate metabolic process, negative regulation of insulin secretion, canonical glycolysis, fructose 1,6-bisphosphate metabolic process
GO CC Complete:	6-phosphofructokinase complex, membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Metabolism of carbohydrates, Glycolysis, Neutrophil degranulation, Immune System, Glucose metabolism, Metabolism, Innate Immune System

Orthologs

ID	Organism	Type
HUMAN\|HGNC=8876\|UniProtKB=P17858	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000022972.5\|UniProtKB=K7DD35	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000005687.3\|UniProtKB=G3RVJ3	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000004173.4\|UniProtKB=A0A5F8AMU1	Macaca mulatta	LDO
MOUSE\|MGI=MGI=97547\|UniProtKB=P12382	Mus musculus	LDO
RAT\|RGD=3311\|UniProtKB=P30835	Rattus norvegicus	LDO
PIG\|Ensembl=ENSSSCG00000028197.4\|UniProtKB=A0A480K104	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000017863.4\|UniProtKB=A0A9L0S0F5	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000003311.6\|UniProtKB=M3W043	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845020069.1\|UniProtKB=A0A8I3P7P5	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000003119.4\|UniProtKB=A0A5F8GF14	Monodelphis domestica	LDO
CHICK\|Ensembl=ENSGALG00010024610.1\|UniProtKB=A0A8V0ZTG8	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000008680.4\|UniProtKB=G1KID2	Anolis carolinensis	LDO
ORYLA\|Ensembl=ENSORLG00000016369.2\|UniProtKB=A0A3B3IF63	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-121207-1\|UniProtKB=E7F9M6	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-050417-62\|UniProtKB=A0A0R4ID68	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000009776.1\|UniProtKB=W5MUA1	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000004612.3\|UniProtKB=F6PYU7	Ciona intestinalis	O
BRAFL\|Gene=LOC118405158\|UniProtKB=A0A9J7HJ52	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC548617\|UniProtKB=A0A7M7N470	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00008230\|UniProtKB=Q27483	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG19122\|UniProtKB=A8XUV3	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00022199\|UniProtKB=Q9TZL8	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG02020\|UniProtKB=A8WRT9	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00276093\|UniProtKB=A0A2A6CR53	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00108378\|UniProtKB=A0A2A6D165	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0003071\|UniProtKB=P52034	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP007642\|UniProtKB=A0A1S4GVQ5	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC005855\|UniProtKB=D6WVW6	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_42792\|UniProtKB=E9FYQ8	Daphnia pulex	O
HELRO\|EnsemblGenome=HelroG63192\|UniProtKB=T1FXB9	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG62554\|UniProtKB=T1FX23	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG63110\|UniProtKB=T1FXB0	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG186529\|UniProtKB=T1FP07	helobdella robusta	O
TRIAD\|EnsemblGenome=TriadG28803\|UniProtKB=B3S470	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_17406\|UniProtKB=A9UR21	Monosiga brevicollis	O
YEAST\|SGD=S000004818\|UniProtKB=P16862	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_AFL185W\|UniProtKB=Q755Q5	Eremothecium gossypii	O
CANAL\|CGD=CAL0000190617\|UniProtKB=Q5AGZ8	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_D16357g\|UniProtKB=P59680	Yarrowia lipolytica	O
YEAST\|SGD=S000003472\|UniProtKB=P16861	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_AEL208W\|UniProtKB=Q758H0	Eremothecium gossypii	O
CANAL\|CGD=CAL0000186427\|UniProtKB=Q5AK53	Candida albicans	O
EMENI\|EnsemblGenome=ANIA_03223\|UniProtKB=Q5B8A7	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_4G00960\|UniProtKB=Q4W9B8	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU00629\|UniProtKB=Q7SI23	Neurospora crassa	O
SCLS1\|Gene_ORFName=SS1G_11603\|UniProtKB=A7F1Y2	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_02539\|UniProtKB=Q0V0C5	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPBC16H5.02\|UniProtKB=O42938	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_00605\|UniProtKB=B6JW37	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNJ01080\|UniProtKB=Q5KAN4	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_02512\|UniProtKB=A0A0D1DZW1	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_05736\|UniProtKB=E3K4D7	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_29700\|UniProtKB=F4NXT6	Batrachochytrium dendrobatidis	O
TRIV3\|Gene_ORFName=TVAG_391760\|UniProtKB=A2DFT9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_496160\|UniProtKB=A2FR66	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_293770\|UniProtKB=A2FKA7	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_462920\|UniProtKB=A2DM03	Trichomonas vaginalis	O
CHLAA\|EnsemblGenome=Caur_0258\|UniProtKB=A9WCU2	Chloroflexus aurantiacus	O
STRCO\|Gene_OrderedLocusName=SCO1214\|UniProtKB=Q9FC99	Streptomyces coelicolor	O
MYCTU\|Gene_OrderedLocusName=Rv3010c\|UniProtKB=P9WID7	Mycobacterium tuberculosis	O
BACTN\|EnsemblGenome=BT_3356\|UniProtKB=Q8A2E9	Bacteroides thetaiotaomicron	O
DICTD\|EnsemblGenome=Dtur_1385\|UniProtKB=B8E0S2	Dictyoglomus turgidum	O
GEOSL\|EnsemblGenome=GSU1703\|UniProtKB=Q74CH0	Geobacter sulfurreducens	O
BRADU\|Gene=Q89RC2_BRADU\|UniProtKB=Q89RC2	Bradyrhizobium diazoefficiens	O
CHLAA\|EnsemblGenome=Caur_0869\|UniProtKB=A9WH07	Chloroflexus aurantiacus	O
STRR6\|EnsemblGenome=spr0796\|UniProtKB=Q8DQ85	Streptococcus pneumoniae	O
STAA8\|EnsemblGenome=SAOUHSC_01807\|UniProtKB=Q2FXM8	Staphylococcus aureus	O
LISMO\|EnsemblGenome=CAC99649\|UniProtKB=Q8Y6W0	Listeria monocytogenes	O
BACSU\|EnsemblGenome=BSU_29190\|UniProtKB=O34529	Bacillus subtilis	O
BACCR\|EnsemblGenome=BC_4600\|UniProtKB=Q817F3	Bacillus cereus	O
THEMA\|EnsemblGenome=TM_0209\|UniProtKB=Q9WY52	Thermotoga maritima	O
DEIRA\|EnsemblGenome=DR_0635\|UniProtKB=Q9RWN1	Deinococcus radiodurans	O
BACTN\|EnsemblGenome=BT_2062\|UniProtKB=Q8A624	Bacteroides thetaiotaomicron	O
BACTN\|EnsemblGenome=BT_1102\|UniProtKB=Q8A8R5	Bacteroides thetaiotaomicron	O
AQUAE\|EnsemblGenome=aq_1708\|UniProtKB=O67605	Aquifex aeolicus	O
DICTD\|EnsemblGenome=Dtur_1388\|UniProtKB=B8E0S5	Dictyoglomus turgidum	O
FUSNN\|EnsemblGenome=FN0410\|UniProtKB=Q8RG98	Fusobacterium nucleatum	O
GEOSL\|EnsemblGenome=GSU2068\|UniProtKB=Q74BH3	Geobacter sulfurreducens	O
COXBU\|EnsemblGenome=CBU_0341\|UniProtKB=Q83EH9	Coxiella burnetii	O
HAEIN\|EnsemblGenome=HI_0982\|UniProtKB=P43863	Haemophilus influenzae	O
VIBCH\|EnsemblGenome=VC_2689\|UniProtKB=Q9KNP2	Vibrio cholerae	O
SALTY\|EnsemblGenome=STM4062\|UniProtKB=P65692	Salmonella typhimurium	O
YERPE\|EnsemblGenome=YP_0080\|UniProtKB=Q8ZJL6	Yersinia pestis	O
ECOLI\|EnsemblGenome=BAE77394\|UniProtKB=P0A796	Escherichia coli	O