PANTHER Gene Information

Gene Symbol(s):

Pfk

Organism:

Drosophila melanogaster

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Gene Name:

ATP-dependent 6-phosphofructokinase

Gene ID:

FBgn0003071

Protein ID:

P52034

Persistent Id:

PTN000344314

Alternate Ids:

Q9V5G7(AltAccession)	Phosphohexokinase {ECO:0000255\|HAMAP-Rule:MF_03184}(Synonym)
FBgn0003071(FlyBase)	PFKA_DROME(UniProtKB-ID)
BT001354(EMBL)	36060(GeneID)
AAN71109(EMBL-CDS)	24652337(GI)
FBgn0003071(Ensembl)	2.7.1.11 {ECO:0000255\|HAMAP-Rule:MF_03184}(EC)
Pfk(Symbol)
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PANTHER Classification

PANTHER Family:	PHOSPHOFRUCTOKINASE (PTHR13697)
PANTHER Subfamily:	ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE (PTHR13697:SF4)
PANTHER GO-slim Molecular Function:	identical protein binding cation binding ATP binding phosphotransferase activity, alcohol group as acceptor carbohydrate kinase activity monosaccharide binding
PANTHER GO-slim Biological Process:	small molecule catabolic process glucose metabolic process glycolytic process
PANTHER GO-slim Cellular Component:	transferase complex, transferring phosphorus-containing groups cytosol
PANTHER protein class:	carbohydrate kinase

Pathway Categories:

Glycolysis

Phosphofructokinase-1

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	ATP binding, fructose-6-phosphate binding, 6-phosphofructokinase activity
GO BP Complete:	glycolytic process, glucose homeostasis, fructose 6-phosphate metabolic process, canonical glycolysis, fructose 1,6-bisphosphate metabolic process, response to sucrose
GO CC Complete:	6-phosphofructokinase complex, cytoplasm, mitochondrion, cytosol

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Glycolysis, Metabolism, Metabolism of carbohydrates, Glucose metabolism, Immune System, Innate Immune System, Neutrophil degranulation

Orthologs

ID	Organism	Type
HUMAN\|HGNC=8876\|UniProtKB=P17858	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000022972.5\|UniProtKB=K7DD35	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000005687.3\|UniProtKB=G3RVJ3	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000004173.4\|UniProtKB=A0A5F8AMU1	Macaca mulatta	O
MOUSE\|MGI=MGI=97547\|UniProtKB=P12382	Mus musculus	O
RAT\|RGD=3311\|UniProtKB=P30835	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000010658\|UniProtKB=A1A4J1	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000028197.4\|UniProtKB=A0A480K104	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000017863.4\|UniProtKB=A0A9L0S0F5	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000003311.6\|UniProtKB=M3W043	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845020069.1\|UniProtKB=A0A8I3P7P5	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000003119.4\|UniProtKB=A0A5F8GF14	Monodelphis domestica	O
CHICK\|Ensembl=ENSGALG00010024610.1\|UniProtKB=A0A8V0ZTG8	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000008680.4\|UniProtKB=G1KID2	Anolis carolinensis	O
ORYLA\|Ensembl=ENSORLG00000016369.2\|UniProtKB=A0A3B3IF63	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-121207-1\|UniProtKB=E7F9M6	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-050417-62\|UniProtKB=A0A0R4ID68	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000009776.1\|UniProtKB=W5MUA1	lepisosteus oculatus	O
HUMAN\|HGNC=8877\|UniProtKB=P08237	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000004874.6\|UniProtKB=K7AUT0	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000006461.3\|UniProtKB=G3QUC7	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000002045.4\|UniProtKB=F6WXR9	Macaca mulatta	LDO
MOUSE\|MGI=MGI=97548\|UniProtKB=P47857	Mus musculus	LDO
RAT\|RGD=68419\|UniProtKB=P47858	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000000286\|UniProtKB=Q0IIG5	Bos taurus	LDO
PIG\|Gene=PFKM\|UniProtKB=Q2HYU2	Sus scrofa	O
PIG\|Ensembl=ENSSSCG00000021129.4\|UniProtKB=A0A287B8N1	Sus scrofa	LDO
HORSE\|Gene=PFKM\|UniProtKB=Q867C9	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000015087.4\|UniProtKB=A0A3Q2GST7	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000014004.6\|UniProtKB=M3WJW8	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845022883.1\|UniProtKB=A0A8I3S3G1	Canis lupus familiaris	LDO
CANLF\|Gene=PFKM\|UniProtKB=P52784	Canis lupus familiaris	LDO
ORNAN\|Ensembl=ENSOANG00000039073.1\|UniProtKB=A0A6I8PJE5	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010024547.1\|UniProtKB=A0A8V1A2C5	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000005562.4\|UniProtKB=A0A803SKZ9	Anolis carolinensis	LDO
XENLA\|Gene=pfkm.L\|UniProtKB=A0A8J0UFC8	Xenopus laevis	O
XENLA\|Gene=pfkm.S\|UniProtKB=Q6DD69	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-1000684\|UniProtKB=A0A8J0QMK3	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000006734.2\|UniProtKB=H2LQW7	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-040912-135\|UniProtKB=Q66HV8	Danio rerio	LDO
ORYLA\|Ensembl=ENSORLG00000001713.2\|UniProtKB=A0A3B3IKM0	Oryzias latipes	O
DANRE\|Gene=pfkmb\|UniProtKB=A0A8M3B3J9	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000007256.1\|UniProtKB=W5MK89	lepisosteus oculatus	LDO
HUMAN\|HGNC=8878\|UniProtKB=Q01813	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000002243.7\|UniProtKB=A0A2I3TMC3	Pan troglodytes	O
MACMU\|Ensembl=ENSMMUG00000004935.4\|UniProtKB=A0A1D5RKW8	Macaca mulatta	O
MOUSE\|MGI=MGI=1891833\|UniProtKB=Q9WUA3	Mus musculus	O
RAT\|RGD=61893\|UniProtKB=P47860	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000002683.6\|UniProtKB=E1BCW3	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000011158.5\|UniProtKB=A0A287AB45	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000020055.4\|UniProtKB=A0A5F5PZA2	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000003235.6\|UniProtKB=A0A5F5XFV8	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845003297.1\|UniProtKB=A0A8I3MLI6	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000006521.4\|UniProtKB=F7E3N2	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000006086.4\|UniProtKB=A0A6I8P7L8	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010005472.1\|UniProtKB=A0A8V0XHN0	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000008018.4\|UniProtKB=A0A803SZZ8	Anolis carolinensis	O
XENLA\|Gene=pfkp.S\|UniProtKB=A0A8J1L0B3	Xenopus laevis	O
XENLA\|Gene=pfkp.L\|UniProtKB=A0A8J1KWP4	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-484391\|UniProtKB=A0A8J0SFS1	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000005745.2\|UniProtKB=A0A3B3IMJ2	Oryzias latipes	O
DANRE\|Gene=pfkpb\|UniProtKB=A0A8M9PAY2	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000004933.2\|UniProtKB=H2LJM4	Oryzias latipes	O
DANRE\|Gene=pfkpa\|UniProtKB=A0A8M2B9C5	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000010769.1\|UniProtKB=W5MXU9	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000004612.3\|UniProtKB=F6PYU7	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118405158\|UniProtKB=A0A9J7HJ52	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC548617\|UniProtKB=A0A7M7N470	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00008230\|UniProtKB=Q27483	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG19122\|UniProtKB=A8XUV3	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00022199\|UniProtKB=Q9TZL8	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG02020\|UniProtKB=A8WRT9	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00276093\|UniProtKB=A0A2A6CR53	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00108378\|UniProtKB=A0A2A6D165	Pristionchus pacificus	LDO
ANOGA\|EnsemblGenome=AGAP007642\|UniProtKB=A0A1S4GVQ5	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC005855\|UniProtKB=D6WVW6	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_42792\|UniProtKB=E9FYQ8	Daphnia pulex	LDO
HELRO\|EnsemblGenome=HelroG63192\|UniProtKB=T1FXB9	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG62554\|UniProtKB=T1FX23	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG63110\|UniProtKB=T1FXB0	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG186529\|UniProtKB=T1FP07	helobdella robusta	LDO
TRIAD\|EnsemblGenome=TriadG28803\|UniProtKB=B3S470	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_17406\|UniProtKB=A9UR21	Monosiga brevicollis	LDO
YEAST\|SGD=S000004818\|UniProtKB=P16862	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_AFL185W\|UniProtKB=Q755Q5	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000190617\|UniProtKB=Q5AGZ8	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_D16357g\|UniProtKB=P59680	Yarrowia lipolytica	LDO
YEAST\|SGD=S000003472\|UniProtKB=P16861	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_AEL208W\|UniProtKB=Q758H0	Eremothecium gossypii	O
CANAL\|CGD=CAL0000186427\|UniProtKB=Q5AK53	Candida albicans	O
EMENI\|EnsemblGenome=ANIA_03223\|UniProtKB=Q5B8A7	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_4G00960\|UniProtKB=Q4W9B8	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU00629\|UniProtKB=Q7SI23	Neurospora crassa	LDO
SCLS1\|Gene_ORFName=SS1G_11603\|UniProtKB=A7F1Y2	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_02539\|UniProtKB=Q0V0C5	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPBC16H5.02\|UniProtKB=O42938	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_00605\|UniProtKB=B6JW37	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNJ01080\|UniProtKB=Q5KAN4	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_02512\|UniProtKB=A0A0D1DZW1	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_05736\|UniProtKB=E3K4D7	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_29700\|UniProtKB=F4NXT6	Batrachochytrium dendrobatidis	LDO
TRIV3\|Gene_ORFName=TVAG_391760\|UniProtKB=A2DFT9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_496160\|UniProtKB=A2FR66	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_293770\|UniProtKB=A2FKA7	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_462920\|UniProtKB=A2DM03	Trichomonas vaginalis	LDO
CHLAA\|EnsemblGenome=Caur_0258\|UniProtKB=A9WCU2	Chloroflexus aurantiacus	O
STRCO\|Gene_OrderedLocusName=SCO1214\|UniProtKB=Q9FC99	Streptomyces coelicolor	O
MYCTU\|Gene_OrderedLocusName=Rv3010c\|UniProtKB=P9WID7	Mycobacterium tuberculosis	O
BACTN\|EnsemblGenome=BT_3356\|UniProtKB=Q8A2E9	Bacteroides thetaiotaomicron	O
DICTD\|EnsemblGenome=Dtur_1385\|UniProtKB=B8E0S2	Dictyoglomus turgidum	O
GEOSL\|EnsemblGenome=GSU1703\|UniProtKB=Q74CH0	Geobacter sulfurreducens	O
BRADU\|Gene=Q89RC2_BRADU\|UniProtKB=Q89RC2	Bradyrhizobium diazoefficiens	O
CHLAA\|EnsemblGenome=Caur_0869\|UniProtKB=A9WH07	Chloroflexus aurantiacus	LDO
STRR6\|EnsemblGenome=spr0796\|UniProtKB=Q8DQ85	Streptococcus pneumoniae	LDO
STAA8\|EnsemblGenome=SAOUHSC_01807\|UniProtKB=Q2FXM8	Staphylococcus aureus	LDO
LISMO\|EnsemblGenome=CAC99649\|UniProtKB=Q8Y6W0	Listeria monocytogenes	LDO
BACSU\|EnsemblGenome=BSU_29190\|UniProtKB=O34529	Bacillus subtilis	LDO
BACCR\|EnsemblGenome=BC_4600\|UniProtKB=Q817F3	Bacillus cereus	LDO
THEMA\|EnsemblGenome=TM_0209\|UniProtKB=Q9WY52	Thermotoga maritima	LDO
DEIRA\|EnsemblGenome=DR_0635\|UniProtKB=Q9RWN1	Deinococcus radiodurans	LDO
BACTN\|EnsemblGenome=BT_2062\|UniProtKB=Q8A624	Bacteroides thetaiotaomicron	O
BACTN\|EnsemblGenome=BT_1102\|UniProtKB=Q8A8R5	Bacteroides thetaiotaomicron	LDO
AQUAE\|EnsemblGenome=aq_1708\|UniProtKB=O67605	Aquifex aeolicus	LDO
DICTD\|EnsemblGenome=Dtur_1388\|UniProtKB=B8E0S5	Dictyoglomus turgidum	LDO
FUSNN\|EnsemblGenome=FN0410\|UniProtKB=Q8RG98	Fusobacterium nucleatum	LDO
GEOSL\|EnsemblGenome=GSU2068\|UniProtKB=Q74BH3	Geobacter sulfurreducens	LDO
COXBU\|EnsemblGenome=CBU_0341\|UniProtKB=Q83EH9	Coxiella burnetii	LDO
HAEIN\|EnsemblGenome=HI_0982\|UniProtKB=P43863	Haemophilus influenzae	LDO
VIBCH\|EnsemblGenome=VC_2689\|UniProtKB=Q9KNP2	Vibrio cholerae	LDO
SALTY\|EnsemblGenome=STM4062\|UniProtKB=P65692	Salmonella typhimurium	LDO
YERPE\|EnsemblGenome=YP_0080\|UniProtKB=Q8ZJL6	Yersinia pestis	LDO
ECOLI\|EnsemblGenome=BAE77394\|UniProtKB=P0A796	Escherichia coli	LDO