PANTHER Gene Information

Gene Symbol(s):

mcm-4

Organism:

Caenorhabditis elegans

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Gene Name:

DNA replication licensing factor mcm-4

Gene ID:

WBGene00003156

Protein ID:

Q95XQ8

Persistent Id:

PTN000180012

Alternate Ids:

171793(GeneID)	NP_490962(refSeq)
CE21767(WormBase_PRO)	WBGene00003156(WormBase)
Y39G10AR.14a(Ensembl_PRO)	Y39G10AR.14a(WormBase_TRS)
MCM4(Synonym)	mcm-4{ECO:0000312\|WormBase:Y39G10AR.14a}(Symbol)
BX284601(EMBL)	Y39G10AR.14a(Ensembl_TRS)
WBGene00003156(Ensembl)	CCD69913(EMBL-CDS)
3.6.4.12 {ECO:0000250\|UniProtKB:Q9NXL9}(EC)	311819696(GI)
MCM4_CAEEL(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER (PTHR11630)
PANTHER Subfamily:	DNA REPLICATION LICENSING FACTOR MCM4 (PTHR11630:SF66)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class:	DNA metabolism protein

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	ATP hydrolysis activity, DNA binding, ATP binding, DNA helicase activity, protein binding, metal ion binding, helicase activity, single-stranded DNA helicase activity, single-stranded DNA binding, hydrolase activity
GO BP Complete:	DNA replication initiation, gonad development, double-strand break repair via break-induced replication, locomotion, DNA replication, DNA strand elongation involved in DNA replication, DNA duplex unwinding, nervous system development, reproductive process, mitotic DNA replication initiation, DNA unwinding involved in DNA replication, cell cycle
GO CC Complete:	nucleus, chromosome, MCM complex

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Assembly of the pre-replicative complex, DNA Replication, Cell Cycle, S Phase, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, Switching of origins to a post-replicative state, Cell Cycle, Mitotic, DNA Replication Pre-Initiation, Synthesis of DNA, G1/S Transition, Activation of the pre-replicative complex

Orthologs

ID	Organism	Type
HUMAN\|HGNC=26368\|UniProtKB=Q4G0Z9	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000020313.6\|UniProtKB=A0A2J8KZT5	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000002768.3\|UniProtKB=G3QJX1	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000065255.1\|UniProtKB=A0A5F8A299	Macaca mulatta	O
MOUSE\|MGI=MGI=3045334\|UniProtKB=E9Q956	Mus musculus	O
RAT\|RGD=1561068\|UniProtKB=Q5XI14	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000000620.4\|UniProtKB=E1BIY0	Bos taurus	O
HORSE\|Ensembl=ENSECAG00000053323.1\|UniProtKB=F7AV04	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000004148.6\|UniProtKB=M3W1N2	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845020001.1\|UniProtKB=A0A8I3P2B5	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000007874.5\|UniProtKB=F7EB87	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000002316.4\|UniProtKB=F6ZS93	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010004128.1\|UniProtKB=A0A8V0XIR8	Gallus gallus	O
XENLA\|Gene=mcmdc2.L\|UniProtKB=A0A1L8FZ43	Xenopus laevis	O
XENTR\|Gene=mcmdc2\|UniProtKB=A0A8J0SGY5	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000008419.2\|UniProtKB=H2LWS7	Oryzias latipes	O
DANRE\|Ensembl=ENSDARG00000106560.2\|UniProtKB=A0A8M1P2I8	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000004629.1\|UniProtKB=W5MAZ6	lepisosteus oculatus	O
BRAFL\|Gene=LOC118408627\|UniProtKB=A0A9J7HT15	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC100890707\|UniProtKB=A0A7M7NHF7	Strongylocentrotus purpuratus	O
HUMAN\|HGNC=6947\|UniProtKB=P33991	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000020230.5\|UniProtKB=H2QW49	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000006080.3\|UniProtKB=G3QTD9	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000015360.4\|UniProtKB=G7MZ95	Macaca mulatta	LDO
MOUSE\|MGI=MGI=103199\|UniProtKB=P49717	Mus musculus	LDO
RAT\|RGD=15014024\|UniProtKB=A0A8I6GIN4	Rattus norvegicus	O
RAT\|RGD=3060\|UniProtKB=G3V681	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000017021.6\|UniProtKB=E1BFZ9	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000006273.5\|UniProtKB=A0A287AU85	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000019276.4\|UniProtKB=F7DJ41	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000011378.6\|UniProtKB=M3WF03	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845028253.1\|UniProtKB=A0A8I3SBE9	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000010213.3\|UniProtKB=F6SAE1	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000007265.4\|UniProtKB=A0A6I8MX74	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010005430.1\|UniProtKB=A0A8V0XLC7	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000012157.4\|UniProtKB=A0A803TND9	Anolis carolinensis	LDO
XENLA\|Gene=mcm4.S\|UniProtKB=A0A1L8FSY2	Xenopus laevis	O
XENLA\|Gene=mcm4-b\|UniProtKB=P30664	Xenopus laevis	O
XENLA\|Gene=mcm4-a\|UniProtKB=Q5XK83	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-1011481\|UniProtKB=Q6GL41	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000017467.2\|UniProtKB=A0A3B3IDX3	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-030131-9544\|UniProtKB=Q6NZV2	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000006026.1\|UniProtKB=W5MFX4	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000007268.3\|UniProtKB=F6THL0	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118417713\|UniProtKB=A0A9J7LCM7	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC582341\|UniProtKB=A0A7M7N534	Strongylocentrotus purpuratus	LDO
CAEBR\|Gene_ORFName=CBG03890\|UniProtKB=A8WVP0	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00304847\|UniProtKB=A0A8R1Z7P6	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0015929\|UniProtKB=Q26454	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP004956\|UniProtKB=Q7PPI5	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC009571\|UniProtKB=D6WSI2	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_329431\|UniProtKB=E9HGK3	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW019440\|UniProtKB=B7PTW9	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG67429\|UniProtKB=T1FZ08	helobdella robusta	LDO
TRIAD\|EnsemblGenome=TriadG35366\|UniProtKB=B3RJ34	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_25497\|UniProtKB=A9UZL0	Monosiga brevicollis	LDO
YEAST\|SGD=S000006223\|UniProtKB=P30665	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_ADL026W\|UniProtKB=Q75AE3	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000176876\|UniProtKB=A0A1D8PFE6	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_F04818g\|UniProtKB=Q6C2V4	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_06070\|UniProtKB=Q5B060	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_2G09060\|UniProtKB=Q4X1R4	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU02539\|UniProtKB=Q7SHS5	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_01278\|UniProtKB=A7E7K0	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_03266\|UniProtKB=Q0UY98	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPCC16A11.17\|UniProtKB=P29458	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_04210\|UniProtKB=B6K682	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNM01820\|UniProtKB=Q5K7N5	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_01646\|UniProtKB=A0A0D1E418	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_11989\|UniProtKB=E3KP08	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_12913\|UniProtKB=F4P7U2	Batrachochytrium dendrobatidis	LDO
ENTH1\|EnsemblGenome=CL6EHI_187720\|UniProtKB=C4M9H9	Entamoeba histolytica	LDO
DICDI\|dictyBase=DDB_G0275623\|UniProtKB=Q86IF1	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_152308\|UniProtKB=F0ZL10	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_09_0250\|UniProtKB=Q4QI01	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb11.01.4070\|UniProtKB=Q382V6	Trypanosoma brucei	LDO
GIAIC\|EnsemblGenome=GL50803_9194\|UniProtKB=A8B7S5	Giardia intestinalis	LDO
TRIV3\|Gene_ORFName=TVAG_250220\|UniProtKB=A2DCM5	Trichomonas vaginalis	LDO
PLAF7\|EnsemblGenome=PF3D7_1317100\|UniProtKB=Q8IEE5	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00015677001\|UniProtKB=A0DCN1	Paramecium tetraurelia	LDO
PARTE\|EnsemblGenome=GSPATT00012268001\|UniProtKB=A0D0Z9	Paramecium tetraurelia	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_269123\|UniProtKB=B8C649	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3GGH5_PHYRM\|UniProtKB=H3GGH5	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_07g316850v5\|UniProtKB=A0A2K3DIP5	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00001p00128450\|UniProtKB=W1NL82	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_3G01980\|UniProtKB=A0A0K9P402	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma01_g16970\|UniProtKB=A0A804HV04	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_000286mg\|UniProtKB=K3XEG9	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3003G183700\|UniProtKB=C5XMX5	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb342080\|UniProtKB=C0PDH6	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb162700\|UniProtKB=B7ZWV7	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os01g0544450\|UniProtKB=Q5JKB0	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_2g40600v3\|UniProtKB=I1HNE4	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0264800\|UniProtKB=F2D1Z2	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS3D02G203400\|UniProtKB=A0A3B6GQV3	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3A02G200400\|UniProtKB=A0A3B6EFD6	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G224600\|UniProtKB=A0A077RWU3	Triticum aestivum	LDO
NELNU\|Gene_ORFName=HUJ06_023918\|UniProtKB=A0A1U8AMF1	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110789558\|UniProtKB=A0A9R0JXC4	Spinacia oleracea	LDO
HELAN\|Gene_ORFName=HanXRQr2_Chr13g0577771\|UniProtKB=A0A9K3EG83	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr03g0086571\|UniProtKB=A0A251V355	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C500272140\|UniProtKB=A0A9R1VCF4	Lactuca sativa	LDO
CAPAN\|EnsemblGenome=T459_01392\|UniProtKB=A0A2G3AH26	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400030968\|UniProtKB=M1D202	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc01g110130.3\|UniProtKB=A0A3Q7EV63	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107799705\|UniProtKB=A0A1S4ANR6	Nicotiana tabacum	O
TOBAC\|Gene=LOC107795484\|UniProtKB=A0A1S4AAF4	Nicotiana tabacum	LDO
VITVI\|Gene_OrderedLocusName=VIT_03s0038g00300\|UniProtKB=D7U5J9	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_G01707\|UniProtKB=A0A059BDU1	Eucalyptus grandis	LDO
BRACM\|EnsemblGenome=Bra013068\|UniProtKB=M4D9A8	Brassica campestris	LDO
ARATH\|TAIR=locus=2042674\|UniProtKB=Q0WVF5	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107913539\|UniProtKB=A0A1U8K555	Gossypium hirsutum	O
GOSHI\|Gene=LOC107920789\|UniProtKB=A0A1U8KUM2	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_006817\|UniProtKB=A0A061DYP2	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g003637mg\|UniProtKB=A0A067EEX3	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_009G121500v3\|UniProtKB=A0A2K1Z6R5	Populus trichocarpa	LDO
RICCO\|Gene_ORFName=RCOM_1449150\|UniProtKB=B9RHA7	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_12G039200\|UniProtKB=I1LPZ2	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_11G113300\|UniProtKB=I1LJ93	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_4g071090\|UniProtKB=G7JIL6	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr16_17340\|UniProtKB=A0A2I4G8U9	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_7G004140\|UniProtKB=A0A0A0K5P7	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_8G088400\|UniProtKB=M5VVB9	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_445155\|UniProtKB=D8SG89	Selaginella moellendorffii	LDO
SELML\|EnsemblGenome=SELMODRAFT_439569\|UniProtKB=D8R623	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c19_18510\|UniProtKB=A0A2K1IYX5	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0007s0227\|UniProtKB=A0A2R6XP23	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_000330310\|UniProtKB=A0A1Y1HLU8	Klebsormidium nitens	LDO
NITMS\|EnsemblGenome=Nmar_0242\|UniProtKB=A9A310	Nitrosopumilus maritimus	LDO
KORCO\|EnsemblGenome=Kcr_1352\|UniProtKB=B1L6L9	Korarchaeum cryptofilum	LDO
SACS2\|EnsemblGenome=SSO0774\|UniProtKB=Q9UXG1	Sulfolobus solfataricus	LDO
PYRAE\|EnsemblGenome=PAE0901\|UniProtKB=Q8ZY88	Pyrobaculum aerophilum	LDO
METAC\|EnsemblGenome=MA_3829\|UniProtKB=Q8TJF6	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_0681\|UniProtKB=Q8TSW4	Methanosarcina acetivorans	LDO
METJA\|EnsemblGenome=MJ_ECL13\|UniProtKB=Q60275	Methanocaldococcus jannaschii	O
METJA\|EnsemblGenome=MJ_1489\|UniProtKB=Q58884	Methanocaldococcus jannaschii	LDO
METJA\|EnsemblGenome=MJ_0363\|UniProtKB=Q57809	Methanocaldococcus jannaschii	O
METJA\|EnsemblGenome=MJ_0961\|UniProtKB=Q58371	Methanocaldococcus jannaschii	O
HALSA\|EnsemblGenome=VNG_2181G\|UniProtKB=Q9HNA5	Halobacterium salinarum	LDO
THEKO\|EnsemblGenome=TK1361\|UniProtKB=Q5JGW1	Thermococcus kodakaraensis	O
THEKO\|EnsemblGenome=TK0096\|UniProtKB=Q5JEJ0	Thermococcus kodakaraensis	O
THEKO\|EnsemblGenome=TK1620\|UniProtKB=Q5JIT1	Thermococcus kodakaraensis	LDO