PANTHER Gene Information

Gene Symbol(s):

dpa

Organism:

Drosophila melanogaster

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Gene Name:

DNA replication licensing factor MCM4

Gene ID:

FBgn0015929

Protein ID:

Q26454

Persistent Id:

PTN000180015

Alternate Ids:

dpa(Symbol)	FBtr0345797(Ensembl_TRS)
FBpp0088055(Ensembl_PRO)	Protein disc proliferation abnormal(Synonym)
S80255(EMBL)	FBgn0015929(FlyBase)
35679(GeneID)	AAB35644(EMBL-CDS)
Q9V4M5(AltAccession)	MCM4_DROME(UniProtKB-ID)
3.6.4.12(EC)	NM_057837(refSeq)
FBgn0015929(Ensembl)	17137242(GI)
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PANTHER Classification

PANTHER Family:	DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER (PTHR11630)
PANTHER Subfamily:	DNA REPLICATION LICENSING FACTOR MCM4 (PTHR11630:SF66)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class:	DNA metabolism protein

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	ATP hydrolysis activity, DNA binding, ATP binding, DNA helicase activity, 3'-5' DNA helicase activity, single-stranded DNA helicase activity, single-stranded DNA binding
GO BP Complete:	DNA replication initiation, double-strand break repair via break-induced replication, DNA replication, DNA strand elongation involved in DNA replication, mitotic spindle organization, DNA duplex unwinding, mitotic DNA replication initiation, DNA unwinding involved in DNA replication
GO CC Complete:	nucleus, CMG complex, MCM complex

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Switching of origins to a post-replicative state, G2/M Checkpoints, Cell Cycle, Orc1 removal from chromatin, G1/S Transition, Synthesis of DNA, Mitotic G1 phase and G1/S transition, Activation of ATR in response to replication stress, Assembly of the pre-replicative complex, DNA Replication, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Activation of the pre-replicative complex, S Phase, DNA Replication Pre-Initiation

Orthologs

ID	Organism	Type
HUMAN\|HGNC=26368\|UniProtKB=Q4G0Z9	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000020313.6\|UniProtKB=A0A2J8KZT5	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000002768.3\|UniProtKB=G3QJX1	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000065255.1\|UniProtKB=A0A5F8A299	Macaca mulatta	O
MOUSE\|MGI=MGI=3045334\|UniProtKB=E9Q956	Mus musculus	O
RAT\|RGD=1561068\|UniProtKB=Q5XI14	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000000620.4\|UniProtKB=E1BIY0	Bos taurus	O
HORSE\|Ensembl=ENSECAG00000053323.1\|UniProtKB=F7AV04	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000004148.6\|UniProtKB=M3W1N2	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845020001.1\|UniProtKB=A0A8I3P2B5	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000007874.5\|UniProtKB=F7EB87	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000002316.4\|UniProtKB=F6ZS93	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010004128.1\|UniProtKB=A0A8V0XIR8	Gallus gallus	O
XENLA\|Gene=mcmdc2.L\|UniProtKB=A0A1L8FZ43	Xenopus laevis	O
XENTR\|Gene=mcmdc2\|UniProtKB=A0A8J0SGY5	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000008419.2\|UniProtKB=H2LWS7	Oryzias latipes	O
DANRE\|Ensembl=ENSDARG00000106560.2\|UniProtKB=A0A8M1P2I8	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000004629.1\|UniProtKB=W5MAZ6	lepisosteus oculatus	O
BRAFL\|Gene=LOC118408627\|UniProtKB=A0A9J7HT15	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC100890707\|UniProtKB=A0A7M7NHF7	Strongylocentrotus purpuratus	O
HUMAN\|HGNC=6947\|UniProtKB=P33991	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000020230.5\|UniProtKB=H2QW49	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000006080.3\|UniProtKB=G3QTD9	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000015360.4\|UniProtKB=G7MZ95	Macaca mulatta	LDO
MOUSE\|MGI=MGI=103199\|UniProtKB=P49717	Mus musculus	LDO
RAT\|RGD=15014024\|UniProtKB=A0A8I6GIN4	Rattus norvegicus	O
RAT\|RGD=3060\|UniProtKB=G3V681	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000017021.6\|UniProtKB=E1BFZ9	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000006273.5\|UniProtKB=A0A287AU85	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000019276.4\|UniProtKB=F7DJ41	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000011378.6\|UniProtKB=M3WF03	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845028253.1\|UniProtKB=A0A8I3SBE9	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000010213.3\|UniProtKB=F6SAE1	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000007265.4\|UniProtKB=A0A6I8MX74	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010005430.1\|UniProtKB=A0A8V0XLC7	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000012157.4\|UniProtKB=A0A803TND9	Anolis carolinensis	LDO
XENLA\|Gene=mcm4.S\|UniProtKB=A0A1L8FSY2	Xenopus laevis	O
XENLA\|Gene=mcm4-b\|UniProtKB=P30664	Xenopus laevis	O
XENLA\|Gene=mcm4-a\|UniProtKB=Q5XK83	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-1011481\|UniProtKB=Q6GL41	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000017467.2\|UniProtKB=A0A3B3IDX3	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-030131-9544\|UniProtKB=Q6NZV2	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000006026.1\|UniProtKB=W5MFX4	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000007268.3\|UniProtKB=F6THL0	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118417713\|UniProtKB=A0A9J7LCM7	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC582341\|UniProtKB=A0A7M7N534	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00003156\|UniProtKB=Q95XQ8	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG03890\|UniProtKB=A8WVP0	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00304847\|UniProtKB=A0A8R1Z7P6	Pristionchus pacificus	LDO
ANOGA\|EnsemblGenome=AGAP004956\|UniProtKB=Q7PPI5	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC009571\|UniProtKB=D6WSI2	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_329431\|UniProtKB=E9HGK3	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW019440\|UniProtKB=B7PTW9	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG67429\|UniProtKB=T1FZ08	helobdella robusta	LDO
TRIAD\|EnsemblGenome=TriadG35366\|UniProtKB=B3RJ34	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_25497\|UniProtKB=A9UZL0	Monosiga brevicollis	LDO
YEAST\|SGD=S000006223\|UniProtKB=P30665	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_ADL026W\|UniProtKB=Q75AE3	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000176876\|UniProtKB=A0A1D8PFE6	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_F04818g\|UniProtKB=Q6C2V4	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_06070\|UniProtKB=Q5B060	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_2G09060\|UniProtKB=Q4X1R4	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU02539\|UniProtKB=Q7SHS5	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_01278\|UniProtKB=A7E7K0	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_03266\|UniProtKB=Q0UY98	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPCC16A11.17\|UniProtKB=P29458	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_04210\|UniProtKB=B6K682	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNM01820\|UniProtKB=Q5K7N5	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_01646\|UniProtKB=A0A0D1E418	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_11989\|UniProtKB=E3KP08	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_12913\|UniProtKB=F4P7U2	Batrachochytrium dendrobatidis	LDO
ENTH1\|EnsemblGenome=CL6EHI_187720\|UniProtKB=C4M9H9	Entamoeba histolytica	LDO
DICDI\|dictyBase=DDB_G0275623\|UniProtKB=Q86IF1	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_152308\|UniProtKB=F0ZL10	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_09_0250\|UniProtKB=Q4QI01	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb11.01.4070\|UniProtKB=Q382V6	Trypanosoma brucei	LDO
GIAIC\|EnsemblGenome=GL50803_9194\|UniProtKB=A8B7S5	Giardia intestinalis	LDO
TRIV3\|Gene_ORFName=TVAG_250220\|UniProtKB=A2DCM5	Trichomonas vaginalis	LDO
PLAF7\|EnsemblGenome=PF3D7_1317100\|UniProtKB=Q8IEE5	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00015677001\|UniProtKB=A0DCN1	Paramecium tetraurelia	LDO
PARTE\|EnsemblGenome=GSPATT00012268001\|UniProtKB=A0D0Z9	Paramecium tetraurelia	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_269123\|UniProtKB=B8C649	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3GGH5_PHYRM\|UniProtKB=H3GGH5	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_07g316850v5\|UniProtKB=A0A2K3DIP5	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00001p00128450\|UniProtKB=W1NL82	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_3G01980\|UniProtKB=A0A0K9P402	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma01_g16970\|UniProtKB=A0A804HV04	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_000286mg\|UniProtKB=K3XEG9	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3003G183700\|UniProtKB=C5XMX5	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb342080\|UniProtKB=C0PDH6	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb162700\|UniProtKB=B7ZWV7	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os01g0544450\|UniProtKB=Q5JKB0	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_2g40600v3\|UniProtKB=I1HNE4	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0264800\|UniProtKB=F2D1Z2	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS3D02G203400\|UniProtKB=A0A3B6GQV3	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3A02G200400\|UniProtKB=A0A3B6EFD6	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G224600\|UniProtKB=A0A077RWU3	Triticum aestivum	LDO
NELNU\|Gene_ORFName=HUJ06_023918\|UniProtKB=A0A1U8AMF1	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110789558\|UniProtKB=A0A9R0JXC4	Spinacia oleracea	LDO
HELAN\|Gene_ORFName=HanXRQr2_Chr13g0577771\|UniProtKB=A0A9K3EG83	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr03g0086571\|UniProtKB=A0A251V355	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C500272140\|UniProtKB=A0A9R1VCF4	Lactuca sativa	LDO
CAPAN\|EnsemblGenome=T459_01392\|UniProtKB=A0A2G3AH26	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400030968\|UniProtKB=M1D202	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc01g110130.3\|UniProtKB=A0A3Q7EV63	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107799705\|UniProtKB=A0A1S4ANR6	Nicotiana tabacum	O
TOBAC\|Gene=LOC107795484\|UniProtKB=A0A1S4AAF4	Nicotiana tabacum	LDO
VITVI\|Gene_OrderedLocusName=VIT_03s0038g00300\|UniProtKB=D7U5J9	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_G01707\|UniProtKB=A0A059BDU1	Eucalyptus grandis	LDO
BRACM\|EnsemblGenome=Bra013068\|UniProtKB=M4D9A8	Brassica campestris	LDO
ARATH\|TAIR=locus=2042674\|UniProtKB=Q0WVF5	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107913539\|UniProtKB=A0A1U8K555	Gossypium hirsutum	O
GOSHI\|Gene=LOC107920789\|UniProtKB=A0A1U8KUM2	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_006817\|UniProtKB=A0A061DYP2	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g003637mg\|UniProtKB=A0A067EEX3	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_009G121500v3\|UniProtKB=A0A2K1Z6R5	Populus trichocarpa	LDO
RICCO\|Gene_ORFName=RCOM_1449150\|UniProtKB=B9RHA7	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_12G039200\|UniProtKB=I1LPZ2	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_11G113300\|UniProtKB=I1LJ93	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_4g071090\|UniProtKB=G7JIL6	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr16_17340\|UniProtKB=A0A2I4G8U9	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_7G004140\|UniProtKB=A0A0A0K5P7	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_8G088400\|UniProtKB=M5VVB9	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_445155\|UniProtKB=D8SG89	Selaginella moellendorffii	LDO
SELML\|EnsemblGenome=SELMODRAFT_439569\|UniProtKB=D8R623	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c19_18510\|UniProtKB=A0A2K1IYX5	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0007s0227\|UniProtKB=A0A2R6XP23	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_000330310\|UniProtKB=A0A1Y1HLU8	Klebsormidium nitens	LDO
NITMS\|EnsemblGenome=Nmar_0242\|UniProtKB=A9A310	Nitrosopumilus maritimus	LDO
KORCO\|EnsemblGenome=Kcr_1352\|UniProtKB=B1L6L9	Korarchaeum cryptofilum	LDO
SACS2\|EnsemblGenome=SSO0774\|UniProtKB=Q9UXG1	Sulfolobus solfataricus	LDO
PYRAE\|EnsemblGenome=PAE0901\|UniProtKB=Q8ZY88	Pyrobaculum aerophilum	LDO
METAC\|EnsemblGenome=MA_3829\|UniProtKB=Q8TJF6	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_0681\|UniProtKB=Q8TSW4	Methanosarcina acetivorans	LDO
METJA\|EnsemblGenome=MJ_ECL13\|UniProtKB=Q60275	Methanocaldococcus jannaschii	O
METJA\|EnsemblGenome=MJ_1489\|UniProtKB=Q58884	Methanocaldococcus jannaschii	LDO
METJA\|EnsemblGenome=MJ_0363\|UniProtKB=Q57809	Methanocaldococcus jannaschii	O
METJA\|EnsemblGenome=MJ_0961\|UniProtKB=Q58371	Methanocaldococcus jannaschii	O
HALSA\|EnsemblGenome=VNG_2181G\|UniProtKB=Q9HNA5	Halobacterium salinarum	LDO
THEKO\|EnsemblGenome=TK1361\|UniProtKB=Q5JGW1	Thermococcus kodakaraensis	O
THEKO\|EnsemblGenome=TK0096\|UniProtKB=Q5JEJ0	Thermococcus kodakaraensis	O
THEKO\|EnsemblGenome=TK1620\|UniProtKB=Q5JIT1	Thermococcus kodakaraensis	LDO