PANTHER Gene Information

Gene Symbol(s):

med-2

Organism:

Caenorhabditis elegans

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Gene Name:

GATA-type domain-containing protein

Gene ID:

WBGene00003181

Protein ID:

G5EF25

Persistent Id:

PTN007419037

Alternate Ids:

K04C2(WormBase_TRS)	BX284603(EMBL)
CE28867(WormBase_PRO)	G5EF25(Synonym)
191706(GeneID)	WBGene00003181(WormBase)
G5EF25_CAEEL(UniProtKB-ID)	CCD72619(EMBL-CDS)
WBGene00003181(Ensembl)	NM_066096(refSeq)
10644756(GI)
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PANTHER Classification

PANTHER Family:	TRANSCRIPTION FACTOR GATA FAMILY MEMBER (PTHR10071)
PANTHER Subfamily:	GATA-TYPE DOMAIN-CONTAINING PROTEIN (PTHR10071:SF312)
PANTHER GO-slim Molecular Function:	RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific
PANTHER GO-slim Biological Process:	negative regulation of transcription by RNA polymerase II cell fate commitment positive regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component:	nucleus
PANTHER protein class:	DNA-binding transcription factor

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	zinc ion binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific
GO BP Complete:	negative regulation of transcription by RNA polymerase II, pharynx development, endodermal cell fate specification, cell fate commitment, regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II
GO CC Complete:	nucleus

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Generic Transcription Pathway, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, Gene expression (Transcription), RNA Polymerase II Transcription, Transcriptional regulation by RUNX1, Surfactant metabolism, Metabolism of proteins

Orthologs

ID	Organism	Type
HUMAN\|HGNC=4170\|UniProtKB=P15976	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000048542.1\|UniProtKB=A0A2I3TBK1	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000023559.2\|UniProtKB=G3RS51	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000016464.4\|UniProtKB=F7GBH5	Macaca mulatta	O
MOUSE\|MGI=MGI=95661\|UniProtKB=P17679	Mus musculus	O
RAT\|RGD=2663\|UniProtKB=P43429	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000003184.5\|UniProtKB=E1BI59	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000027237.3\|UniProtKB=I3LEA0	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000037888.3\|UniProtKB=F6Q516	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000010904.4\|UniProtKB=M3WE57	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845030905.1\|UniProtKB=A0A8I3QVV2	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000010099.4\|UniProtKB=F6X583	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000010765.3\|UniProtKB=F6Y2Q0	Ornithorhynchus anatinus	O
CHICK\|Gene=GATA1\|UniProtKB=P17678	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000007871.4\|UniProtKB=G1KH54	Anolis carolinensis	O
XENLA\|Gene=gata1.S\|UniProtKB=A0A1L8F426	Xenopus laevis	O
XENLA\|Gene=gata1-b\|UniProtKB=P23768	Xenopus laevis	O
XENLA\|Gene=gata1-a\|UniProtKB=P23767	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-484636\|UniProtKB=F6YQX8	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000013980.2\|UniProtKB=Q76B16	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-980526-268\|UniProtKB=Q90410	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000014759.1\|UniProtKB=W5NC15	lepisosteus oculatus	O
DANRE\|Gene=gata1b\|UniProtKB=A0A8M9QAH1	Danio rerio	O
HUMAN\|HGNC=4171\|UniProtKB=P23769	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000015355.7\|UniProtKB=H2RAN3	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000006156.3\|UniProtKB=G3QTJ7	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000021371.4\|UniProtKB=F6VIP3	Macaca mulatta	O
MOUSE\|MGI=MGI=95662\|UniProtKB=O09100	Mus musculus	O
RAT\|RGD=2664\|UniProtKB=Q924Y4	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000019707.6\|UniProtKB=E1BAM5	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000011618.5\|UniProtKB=Q865U9	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000016768.4\|UniProtKB=A0A3Q2IAT8	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000006154.6\|UniProtKB=M3W5E4	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845018934.1\|UniProtKB=A0A8I3S3Q3	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000008048.4\|UniProtKB=F6ZA02	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000029173.2\|UniProtKB=K7EFI3	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010026920.1\|UniProtKB=A0A8V1AC24	Gallus gallus	O
CHICK\|Gene=GATA2\|UniProtKB=P23824	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000045513.1\|UniProtKB=A0A803TF09	Anolis carolinensis	O
XENLA\|Gene=gata2\|UniProtKB=P23770	Xenopus laevis	O
XENLA\|Gene=gata2.S\|UniProtKB=A0A8J1KK25	Xenopus laevis	O
XENLA\|Gene=gata2.L\|UniProtKB=A0A1L8GPW2	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-478165\|UniProtKB=F6UN64	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000001368.2\|UniProtKB=Q5KST7	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000007736.2\|UniProtKB=H2LUB1	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-980526-260\|UniProtKB=A0A8M3AXB8	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000014539.1\|UniProtKB=W5NB85	lepisosteus oculatus	O
HUMAN\|HGNC=4172\|UniProtKB=P23771	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000023695.5\|UniProtKB=H2R285	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000006161.3\|UniProtKB=G3QTK0	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000006944.4\|UniProtKB=F7E1F3	Macaca mulatta	O
MOUSE\|MGI=MGI=95663\|UniProtKB=P23772	Mus musculus	O
RAT\|RGD=621250\|UniProtKB=Q99NH5	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000017243.6\|UniProtKB=A0A452DIR6	Bos taurus	O
BOVIN\|Gene=GATA3\|UniProtKB=Q08DV0	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000011125.5\|UniProtKB=F1RUM8	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000024574.3\|UniProtKB=A0A3Q2GUN5	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000042993.2\|UniProtKB=A0A337SB50	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845001133.1\|UniProtKB=A0A8I3MCW5	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000016735.4\|UniProtKB=F7BYS6	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000046997.1\|UniProtKB=A0A6I8N6R9	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010005232\|UniProtKB=P23825	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000009109.4\|UniProtKB=H9GET8	Anolis carolinensis	O
XENLA\|Gene=gata3.S\|UniProtKB=Q2TAR8	Xenopus laevis	O
XENLA\|Gene=gata3\|UniProtKB=P23773	Xenopus laevis	O
XENLA\|Gene=gata3.L\|UniProtKB=A0A1L8GZE8	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-485930\|UniProtKB=Q6DIQ6	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000017122.2\|UniProtKB=H2MRP1	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-040718-440\|UniProtKB=F1QD30	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-990415-82\|UniProtKB=Q91428	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000015684.1\|UniProtKB=W5NF99	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000004437.3\|UniProtKB=F6Y3C0	Ciona intestinalis	O
BRAFL\|Gene=GATA123\|UniProtKB=C5HZ32	Branchiostoma floridae	O
BRAFL\|Gene=LOC118416769\|UniProtKB=A0A9J7MSV0	Branchiostoma floridae	O
STRPU\|EnsemblGenome=GeneID_373316\|UniProtKB=A0A7M7LWQ0	Strongylocentrotus purpuratus	O
CAEBR\|WormBase=WBGene00034436\|UniProtKB=A8XIJ2	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00037625\|UniProtKB=A8XT51	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00037626\|UniProtKB=A8XT52	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00089767\|UniProtKB=A0A2A6BGA4	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00112597\|UniProtKB=A0A2A6BLT8	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00091094\|UniProtKB=A0A2A6BHR6	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00095442\|UniProtKB=A0A2A6C441	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00276968\|UniProtKB=A0A2A6BYX7	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00273964\|UniProtKB=A0A2A6B7Y3	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0003507\|UniProtKB=P52172	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0032223\|UniProtKB=Q9VKZ0	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0038391\|UniProtKB=Q9VF00	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0001138\|UniProtKB=P91623	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP002236\|UniProtKB=A0A453YQ15	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP004228\|UniProtKB=A0A1S4GKY6	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC010406\|UniProtKB=D6WKS0	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC002315\|UniProtKB=D7EHV3	Tribolium castaneum	O
IXOSC\|EnsemblGenome=ISCW005453\|UniProtKB=B7PQI7	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW004992\|UniProtKB=B7PFW5	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG145054\|UniProtKB=T1EJI3	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g196609\|UniProtKB=A7RFY2	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG56374\|UniProtKB=B3RXY6	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG59720\|UniProtKB=B3S690	Trichoplax adhaerens	O
YEAST\|SGD=S000001873\|UniProtKB=P43574	Saccharomyces cerevisiae	O
YEAST\|SGD=S000000842\|UniProtKB=P18494	Saccharomyces cerevisiae	O
YEAST\|SGD=S000003646\|UniProtKB=P42944	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_AFR513C\|UniProtKB=Q752R0	Eremothecium gossypii	O
EREGS\|EnsemblGenome=AGOS_AFR237W\|UniProtKB=Q754I0	Eremothecium gossypii	O
EREGS\|EnsemblGenome=AGOS_AFR069C\|UniProtKB=Q754K3	Eremothecium gossypii	O
CANAL\|CGD=CAL0000189426\|UniProtKB=A0A1D8PNX9	Candida albicans	O
CANAL\|CGD=CAL0000193023\|UniProtKB=Q59TU4	Candida albicans	O
CANAL\|CGD=CAL0000197994\|UniProtKB=Q5A432	Candida albicans	O
CANAL\|CGD=CAL0000183131\|UniProtKB=Q5A201	Candida albicans	O
EMENI\|EnsemblGenome=ANIA_08667\|UniProtKB=P17429	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_6G01970\|UniProtKB=Q4WCP6	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU09068\|UniProtKB=P19212	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_05040\|UniProtKB=A7EI98	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_07400\|UniProtKB=Q0ULG4	Phaeosphaeria nodorum	O
EMENI\|EnsemblGenome=ANIA_06221\|UniProtKB=G5EB05	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_2G13380\|UniProtKB=Q4X0I2	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU15829\|UniProtKB=Q9HEV5	Neurospora crassa	O
SCLS1\|Gene_ORFName=SS1G_09784\|UniProtKB=A7EWS5	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_13332\|UniProtKB=Q0U4I2	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPCC1902.01\|UniProtKB=Q10280	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_02730\|UniProtKB=B6K112	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNI04020\|UniProtKB=Q5KB26	Cryptococcus neoformans	O
CRYNJ\|EnsemblGenome=CNJ02920\|UniProtKB=Q5KA62	Cryptococcus neoformans	O
CRYNJ\|EnsemblGenome=CNA01820\|UniProtKB=Q5KPR4	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_10417\|UniProtKB=A0A0D1DVL4	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_14141\|UniProtKB=E3KX32	Puccinia graminis	O
PUCGT\|EnsemblGenome=PGTG_02717\|UniProtKB=E3JW51	Puccinia graminis	O
CANAL\|CGD=CAL0000194032\|UniProtKB=Q5AP95	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_E05555g\|UniProtKB=Q6C6X2	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_00176\|UniProtKB=G5EB20	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_5G11260\|UniProtKB=Q4WV91	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU07728\|UniProtKB=Q1K8E7	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_08523\|UniProtKB=A7ET68	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_14013\|UniProtKB=Q0U2M0	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPCC1393.08\|UniProtKB=O94720	Schizosaccharomyces pombe	O
SCHPO\|PomBase=SPAC23E2.01\|UniProtKB=Q10134	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_04249\|UniProtKB=B6K6C1	Schizosaccharomyces japonicus	O
SCHJY\|EnsemblGenome=SJAG_00792\|UniProtKB=B6JWL5	Schizosaccharomyces japonicus	O
USTMA\|EnsemblGenome=UMAG_03708\|UniProtKB=A0A0D1DV43	Ustilago maydis	O
USTMA\|EnsemblGenome=UMAG_01050\|UniProtKB=P40349	Ustilago maydis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_85624\|UniProtKB=F4NRM3	Batrachochytrium dendrobatidis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_34165\|UniProtKB=F4NSC3	Batrachochytrium dendrobatidis	O
DICDI\|dictyBase=DDB_G0280639\|UniProtKB=Q54V37	Dictyostelium discoideum	O
CHLRE\|EnsemblGenome=CHLRE_06g266850v5\|UniProtKB=A0A2K3DN23	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_11g467581v5\|UniProtKB=A0A2K3D7C3	Chlamydomonas reinhardtii	O