PANTHER Gene Information

Gene Symbol(s):

hlh-30

Organism:

Caenorhabditis elegans

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Gene Name:

Helix-loop-helix protein 30

Gene ID:

WBGene00020930

Protein ID:

H2KZZ2

Persistent Id:

PTN000000877

Alternate Ids:

CCD70594(EMBL-CDS)	W02C12.3d(WormBase_TRS)
WBGene00020930(Ensembl)	BX284604(EMBL)
H2KZZ4(AltAccession)	351062580(GI)
HLH30_CAEEL(UniProtKB-ID)	NM_001028245(refSeq)
177157(GeneID)	HLH30(Synonym)
CE33712(WormBase_PRO)	WBGene00020930(WormBase)
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PANTHER Classification

PANTHER Family:	MIP04163P (PTHR45776)
PANTHER Subfamily:	MIP04163P (PTHR45776:SF2)
PANTHER GO-slim Molecular Function:	DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding
PANTHER GO-slim Biological Process:	regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component:	nucleus
PANTHER protein class:	basic helix-loop-helix transcription factor

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein dimerization activity, DNA-binding transcription factor activity, RNA polymerase II-specific
GO BP Complete:	positive regulation of macroautophagy, defense response to Gram-negative bacterium, determination of adult lifespan, positive regulation of gene expression, positive regulation of plasma membrane repair, regulation of autophagy, cellular response to toxic substance, positive regulation of transcription by RNA polymerase II, defense response to Gram-positive bacterium, regulation of transcription by RNA polymerase II, positive regulation of xenophagy
GO CC Complete:	nucleus, cytoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

SUMO E3 ligases SUMOylate target proteins, SUMOylation of transcription factors, Post-translational protein modification, SUMOylation, Metabolism of proteins

Orthologs

ID	Organism	Type
HUMAN\|HGNC=11753\|UniProtKB=P19484	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000018157.7\|UniProtKB=H2QSZ5	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000002683.3\|UniProtKB=G3RXC5	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000004690.4\|UniProtKB=F7FXN6	Macaca mulatta	O
MOUSE\|MGI=MGI=103270\|UniProtKB=Q9R210	Mus musculus	O
RAT\|RGD=1309583\|UniProtKB=F7F5J1	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000012384.6\|UniProtKB=F1MX26	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000001621.5\|UniProtKB=F1RUY2	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000019762.3\|UniProtKB=F7E1U7	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000011521.6\|UniProtKB=A0A2I2V3G1	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845015601.1\|UniProtKB=A0A8I3NYB7	Canis lupus familiaris	O
ORNAN\|Ensembl=ENSOANG00000015438.4\|UniProtKB=F6TIG8	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010026402.1\|UniProtKB=A0A8V1AD97	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000002664.3\|UniProtKB=G1KB16	Anolis carolinensis	O
XENLA\|Gene=tfeb.S\|UniProtKB=A0A8J1MDJ3	Xenopus laevis	O
XENTR\|Gene=tfeb\|UniProtKB=A0A8J1J5S8	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000015866.3\|UniProtKB=H2MMD1	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-090807-3\|UniProtKB=A0A2R8RRI1	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000012145.1\|UniProtKB=W5N2T2	lepisosteus oculatus	O
HUMAN\|HGNC=11754\|UniProtKB=O14948	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000047353\|UniProtKB=A2T713	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000009901.3\|UniProtKB=A0A2I2Y530	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000038489.2\|UniProtKB=A0A1D5QUV2	Macaca mulatta	O
MOUSE\|MGI=MGI=1333760\|UniProtKB=Q9WTW4	Mus musculus	O
RAT\|RGD=3846\|UniProtKB=Q63302	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000014228.6\|UniProtKB=A0A3Q1LFW9	Bos taurus	O
BOVIN\|Gene=TFEC\|UniProtKB=A4IFU7	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000038138.3\|UniProtKB=A0A287BAS8	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000013937.4\|UniProtKB=F7BMF4	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000027627.4\|UniProtKB=A0A2I2UUF2	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845006297.1\|UniProtKB=A0A8I3N2H0	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000013198.3\|UniProtKB=F7FA62	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000015845.4\|UniProtKB=F7DUX6	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000014094.3\|UniProtKB=A0A6I8N1N4	Ornithorhynchus anatinus	O
CHICK\|Gene=TFEC\|UniProtKB=Q5XFQ6	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010001219.1\|UniProtKB=A0A8V0X7F5	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000036278.1\|UniProtKB=A0A803T982	Anolis carolinensis	O
XENLA\|Gene=LOC108711135\|UniProtKB=A0A8J0UR63	Xenopus laevis	O
XENLA\|Gene=LOC108713110\|UniProtKB=A0A8J1MRN3	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-986001\|UniProtKB=A0A803KCB8	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000010461.2\|UniProtKB=A0A3B3I0H0	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-041210-21\|UniProtKB=Q1JQ62	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000015941.1\|UniProtKB=W5NG68	lepisosteus oculatus	O
HUMAN\|HGNC=11752\|UniProtKB=P19532	Homo sapiens	LDO
GORGO\|Ensembl=ENSGGOG00000014023.4\|UniProtKB=A0A2I2YS93	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000023494.4\|UniProtKB=A0A1D5QF51	Macaca mulatta	LDO
MOUSE\|MGI=MGI=98511\|UniProtKB=Q64092	Mus musculus	LDO
RAT\|RGD=1559642\|UniProtKB=A0A8I5ZPP5	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000008523\|UniProtKB=Q05B92	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000012287.6\|UniProtKB=F1RW57	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000020642.3\|UniProtKB=F6T5E1	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000002574.5\|UniProtKB=M3VYS0	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845031022.1\|UniProtKB=A0A8I3S7X7	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000009925.4\|UniProtKB=A0A5F8GMJ1	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000013574.3\|UniProtKB=A0A6I8MYD3	Ornithorhynchus anatinus	LDO
ANOCA\|Ensembl=ENSACAG00000022140.3\|UniProtKB=H9GTC2	Anolis carolinensis	LDO
XENLA\|Gene=tfe3.L\|UniProtKB=A0A1L8F5F4	Xenopus laevis	O
XENLA\|Gene=tfe3.S\|UniProtKB=Q5XHC0	Xenopus laevis	LDO
XENTR\|Ensembl=ENSXETG00000047721\|UniProtKB=A0A803J330	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000029338.1\|UniProtKB=A0A3B3ILR6	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000014134.2\|UniProtKB=H2MGI4	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-010919-3\|UniProtKB=F1R1N1	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-010919-2\|UniProtKB=Q561Z2	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000014691.1\|UniProtKB=W5NBS7	lepisosteus oculatus	LDO
HUMAN\|HGNC=7105\|UniProtKB=O75030	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000015100.5\|UniProtKB=A0A2I3RWW4	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000024338.2\|UniProtKB=A0A2I2YQK2	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000002100.4\|UniProtKB=H9ELZ8	Macaca mulatta	O
MOUSE\|MGI=MGI=104554\|UniProtKB=Q08874	Mus musculus	O
RAT\|RGD=3092\|UniProtKB=O88368	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000006679.7\|UniProtKB=A0A3Q1MKP6	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000011514.5\|UniProtKB=D2JUK3	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000005360.4\|UniProtKB=F6ZKQ4	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000024419.4\|UniProtKB=A0A2I2UHM0	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845009666.1\|UniProtKB=A0A8I3N265	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000003754.4\|UniProtKB=F7DV34	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000012406.4\|UniProtKB=F7DUA0	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010022062.1\|UniProtKB=A0A3Q2U6P0	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000036061.1\|UniProtKB=A0A803TPW1	Anolis carolinensis	O
XENLA\|Gene=mitf.S\|UniProtKB=A0A8J0V374	Xenopus laevis	O
XENLA\|Gene=Mitf-M\|UniProtKB=Q76DN3	Xenopus laevis	O
XENLA\|Gene=mitf.L\|UniProtKB=Q76DN4	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-484962\|UniProtKB=A4IID0	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000003123.2\|UniProtKB=K9L437	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000013461.2\|UniProtKB=A0A3B3HNN5	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-990910-11\|UniProtKB=Q9PWC2	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-010919-1\|UniProtKB=F1Q885	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000010058.1\|UniProtKB=W5MV93	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000004702.3\|UniProtKB=F6QNF1	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118415416\|UniProtKB=A0A9J7MPM9	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC577766\|UniProtKB=A0A7M7RDY6	Strongylocentrotus purpuratus	LDO
CAEBR\|WormBase=WBGene00042922\|UniProtKB=H8WHA0	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG05364\|UniProtKB=A8WZP5	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00202776\|UniProtKB=A0A2A6BYJ1	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0263112\|UniProtKB=C3KGP2	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP000807\|UniProtKB=A7USK4	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC014225\|UniProtKB=A0A139WP70	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_96359\|UniProtKB=E9FXN6	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW011795\|UniProtKB=B7Q780	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW011796\|UniProtKB=B7Q781	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG180867\|UniProtKB=T1FGC6	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g240998\|UniProtKB=A7RVM3	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG60032\|UniProtKB=B3S741	Trichoplax adhaerens	LDO
YEAST\|SGD=S000000199\|UniProtKB=P38165	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_ADR067W\|UniProtKB=Q75A52	Eremothecium gossypii	LDO
YARLI\|EnsemblGenome=YALI0_F11979g\|UniProtKB=Q6C201	Yarrowia lipolytica	LDO