PANTHER Gene Information   
Gene Symbol(s): PSME4
Organism: Canis lupus familiaris
View Gene in Tree
Tree
Tree
Gene Name: Proteasome activator subunit 4
Gene ID: ENSCAFG00845008342.1
Protein ID: A0A8I3N952
Persistent Id: PTN001282323
Alternate Ids:
A0A8I3N952(Synonym) ENSCAFG00845008342(Ensembl)
ENSCAFP00845011620(Ensembl_PRO) A0A8I3N952_CANLF(UniProtKB-ID)
ENSCAFT00845014984(Ensembl_TRS)
Show All

PANTHER Classification
PANTHER Family: PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4 (PTHR32170)
PANTHER Subfamily: PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4 (PTHR32170:SF3)  
PANTHER GO-slim Molecular Function: histone binding
modification-dependent protein binding
proteasome binding
peptidase activator activity
PANTHER GO-slim Biological Process: proteasomal protein catabolic process
PANTHER GO-slim Cellular Component: cytosol
nucleus
PANTHER protein class:
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: peptidase activator activity, proteasome binding, lysine-acetylated histone binding
GO BP Complete: DNA repair, proteasomal ubiquitin-independent protein catabolic process
GO CC Complete: spermatoproteasome complex, nucleus, cytosol
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: PCP/CE pathway, Ub-specific processing proteases, Class I MHC mediated antigen processing & presentation, Antigen processing: Ubiquitination & Proteasome degradation, Degradation of DVL, Regulation of ornithine decarboxylase (ODC), MAPK1/MAPK3 signaling, G2/M Transition, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Cell Cycle, Mitotic, Degradation of AXIN, TNFR2 non-canonical NF-kB pathway, Activation of NF-kappaB in B cells, Interleukin-1 signaling, Regulation of mitotic cell cycle, Mitotic G2-G2/M phases, Transport of small molecules, Innate Immune System, ABC-family proteins mediated transport, DNA Replication, Intracellular signaling by second messengers, Metabolism of RNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Stabilization of p53, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, NIK-->noncanonical NF-kB signaling, Regulation of RAS by GAPs, The role of GTSE1 in G2/M progression after G2 checkpoint, RAF/MAP kinase cascade, CDK-mediated phosphorylation and removal of Cdc6, MAPK6/MAPK4 signaling, APC/C:Cdc20 mediated degradation of mitotic proteins, TCF dependent signaling in response to WNT, PTEN Regulation, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Degradation of beta-catenin by the destruction complex, Adaptive Immune System, TCR signaling, Beta-catenin independent WNT signaling, Cytokine Signaling in Immune system, G2/M Checkpoints, Downstream signaling events of B Cell Receptor (BCR), S Phase, Cell Cycle, MAPK family signaling cascades, Cellular responses to stress, Mitotic Metaphase and Anaphase, Asymmetric localization of PCP proteins, Signaling by Interleukins, Regulation of mRNA stability by proteins that bind AU-rich elements, Orc1 removal from chromatin, Regulation of PTEN stability and activity, Synthesis of DNA, UCH proteinases, Cellular response to hypoxia, Metabolism of amino acids and derivatives, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, Hedgehog 'on' state, APC/C:Cdc20 mediated degradation of Securin, Downstream TCR signaling, Signal Transduction, Separation of Sister Chromatids, Ubiquitin-dependent degradation of Cyclin D, PIP3 activates AKT signaling, KEAP1-NFE2L2 pathway, Cellular responses to stimuli, p53-Dependent G1/S DNA damage checkpoint, Metabolism of polyamines, Post-translational protein modification, Metabolism, AUF1 (hnRNP D0) binds and destabilizes mRNA, C-type lectin receptors (CLRs), Cell Cycle Checkpoints, Interleukin-1 family signaling, Hedgehog ligand biogenesis, APC/C-mediated degradation of cell cycle proteins, Signaling by the B Cell Receptor (BCR), FCERI mediated NF-kB activation, p53-Independent DNA Damage Response, Mitotic Anaphase, p53-Independent G1/S DNA damage checkpoint, Signaling by WNT, Immune System, Cellular response to chemical stress, G1/S DNA Damage Checkpoints, Degradation of GLI1 by the proteasome, Neddylation, Switching of origins to a post-replicative state, GLI3 is processed to GLI3R by the proteasome, Hedgehog 'off' state, M Phase, Metabolism of proteins, Fc epsilon receptor (FCERI) signaling, Dectin-1 mediated noncanonical NF-kB signaling, Autodegradation of the E3 ubiquitin ligase COP1, CLEC7A (Dectin-1) signaling, Signaling by Hedgehog, Antigen processing-Cross presentation, Cross-presentation of soluble exogenous antigens (endosomes), Ubiquitin Mediated Degradation of Phosphorylated Cdc25A, Deubiquitination, p53-Dependent G1 DNA Damage Response

Orthologs