PANTHER Gene Information   
Gene Symbol(s): PSME4
Organism: Sus scrofa
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Gene Name: Proteasome activator complex subunit 4
Gene ID: ENSSSCG00000008412.5
Protein ID: A0A287APQ3
Persistent Id: PTN001594767
Alternate Ids:
A0A287APQ3_PIG(UniProtKB-ID) DQIR01222549(EMBL)
ENSSSCP00000046047(Ensembl_PRO) ENSSSCG00005044630(Ensembl)
ENSSSCT00005072158(Ensembl_TRS) A0A287APQ3(Synonym)
HDB78026(EMBL-CDS)
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PANTHER Classification
PANTHER Family: PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4 (PTHR32170)
PANTHER Subfamily: PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4 (PTHR32170:SF3)  
PANTHER GO-slim Molecular Function: histone binding
modification-dependent protein binding
proteasome binding
peptidase activator activity
PANTHER GO-slim Biological Process: proteasomal protein catabolic process
PANTHER GO-slim Cellular Component: cytosol
nucleus
PANTHER protein class:
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: peptidase activator activity, proteasome binding, lysine-acetylated histone binding
GO BP Complete: DNA repair, sperm DNA condensation, proteasomal ubiquitin-independent protein catabolic process
GO CC Complete: spermatoproteasome complex, nucleus, cytosol, nucleoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: TNFR2 non-canonical NF-kB pathway, TCR signaling, Ub-specific processing proteases, Metabolism of proteins, Metabolism of amino acids and derivatives, Gene expression (Transcription), Degradation of DVL, S Phase, Degradation of AXIN, PCP/CE pathway, MAPK1/MAPK3 signaling, Innate Immune System, Ubiquitin-dependent degradation of Cyclin D, G2/M Checkpoints, Downstream signaling events of B Cell Receptor (BCR), Synthesis of DNA, Orc1 removal from chromatin, TCF dependent signaling in response to WNT, Hedgehog 'off' state, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, GLI3 is processed to GLI3R by the proteasome, Regulation of RAS by GAPs, Degradation of GLI1 by the proteasome, Cell Cycle, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Deubiquitination, ABC-family proteins mediated transport, Transport of small molecules, Metabolism, Metabolism of polyamines, Mitotic G2-G2/M phases, Cellular response to chemical stress, Regulation of mitotic cell cycle, Downstream TCR signaling, Cytokine Signaling in Immune system, Adaptive Immune System, Interleukin-1 family signaling, Signaling by WNT, Intracellular signaling by second messengers, Cell Cycle Checkpoints, MAPK6/MAPK4 signaling, Hedgehog 'on' state, APC/C-mediated degradation of cell cycle proteins, Neddylation, FCERI mediated NF-kB activation, p53-Dependent G1/S DNA damage checkpoint, G1/S DNA Damage Checkpoints, p53-Independent G1/S DNA damage checkpoint, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Mitotic Anaphase, NIK-->noncanonical NF-kB signaling, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, Immune System, M Phase, Interleukin-1 signaling, p53-Independent DNA Damage Response, Metabolism of RNA, The role of GTSE1 in G2/M progression after G2 checkpoint, RAF/MAP kinase cascade, Autodegradation of the E3 ubiquitin ligase COP1, PIP3 activates AKT signaling, Separation of Sister Chromatids, Signaling by the B Cell Receptor (BCR), Switching of origins to a post-replicative state, Signal Transduction, Post-translational protein modification, p53-Dependent G1 DNA Damage Response, Fc epsilon receptor (FCERI) signaling, Signaling by Interleukins, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A, Signaling by Hedgehog, Regulation of mRNA stability by proteins that bind AU-rich elements, Cellular response to hypoxia, UCH proteinases, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, RUNX1 regulates transcription of genes involved in differentiation of HSCs, AUF1 (hnRNP D0) binds and destabilizes mRNA, Asymmetric localization of PCP proteins, Cell Cycle, Mitotic, G2/M Transition, MAPK family signaling cascades, Cellular responses to stress, PTEN Regulation, Mitotic Metaphase and Anaphase, APC/C:Cdc20 mediated degradation of Securin, Beta-catenin independent WNT signaling, Cross-presentation of soluble exogenous antigens (endosomes), Activation of NF-kappaB in B cells, DNA Replication, APC/C:Cdc20 mediated degradation of mitotic proteins, Stabilization of p53, Transcriptional regulation by RUNX1, Dectin-1 mediated noncanonical NF-kB signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, CLEC7A (Dectin-1) signaling, RNA Polymerase II Transcription, Antigen processing-Cross presentation, Regulation of ornithine decarboxylase (ODC), C-type lectin receptors (CLRs), Degradation of beta-catenin by the destruction complex, Hedgehog ligand biogenesis, CDK-mediated phosphorylation and removal of Cdc6, Generic Transcription Pathway, Regulation of PTEN stability and activity, KEAP1-NFE2L2 pathway, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Cellular responses to stimuli

Orthologs