PANTHER Gene Information

Gene Symbol(s):

PDGFRA

Organism:

Canis lupus familiaris

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Gene Name:

Platelet-derived growth factor receptor alpha

Gene ID:

ENSCAFG00845011775.1

Protein ID:

A0A8I3NAN8

Persistent Id:

PTN009099520

Alternate Ids:

ENSCAFP00845016489(Ensembl_PRO)	442860(GeneID)
ENSCAFT00845020983(Ensembl_TRS)	A0A8I3NAN8_CANLF(UniProtKB-ID)
ENSCAFG00845011775(Ensembl)	A0A8I3NAN8(Synonym)
XM_005628195(refSeq)	545521523(GI)
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PANTHER Classification

PANTHER Family:	TYROSINE-PROTEIN KINASE RECEPTOR (PTHR24416)
PANTHER Subfamily:	PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA (PTHR24416:SF52)
PANTHER GO-slim Molecular Function:	growth factor binding transmembrane receptor protein tyrosine kinase activity
PANTHER GO-slim Biological Process:	transmembrane receptor protein tyrosine kinase signaling pathway chordate embryonic development embryonic organ development positive regulation of kinase activity embryonic morphogenesis animal organ morphogenesis skeletal system development
PANTHER GO-slim Cellular Component:	receptor complex plasma membrane
PANTHER protein class:	transmembrane signal receptor

Pathway Categories:

PDGF signaling pathway

Platelet-Derived Growth Factor A

Angiogenesis

Platelet-Derived Growth Factor Receptor

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	platelet-derived growth factor alpha-receptor activity, ATP binding, protein homodimerization activity, platelet-derived growth factor receptor binding, metal ion binding, vascular endothelial growth factor receptor activity, phospholipase C activator activity, vascular endothelial growth factor binding, platelet-derived growth factor binding, protein-containing complex binding
GO BP Complete:	retina vasculature development in camera-type eye, multicellular organism development, roof of mouth development, signal transduction involved in regulation of gene expression, odontogenesis of dentin-containing tooth, embryonic digestive tract morphogenesis, positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway, hematopoietic progenitor cell differentiation, face morphogenesis, cell chemotaxis, positive regulation of calcium-mediated signaling, white fat cell differentiation, cellular response to amino acid stimulus, regulation of mesenchymal stem cell differentiation, in utero embryonic development, positive regulation of fibroblast proliferation, cardiac myofibril assembly, platelet aggregation, adrenal gland development, lung development, estrogen metabolic process, platelet-derived growth factor receptor-alpha signaling pathway, cell surface receptor protein tyrosine kinase signaling pathway, embryonic cranial skeleton morphogenesis, luteinization, male genitalia development, metanephric glomerular capillary formation, positive regulation of ERK1 and ERK2 cascade, extracellular matrix organization, negative regulation of platelet activation, Leydig cell differentiation, cellular response to reactive oxygen species, positive regulation of chemotaxis, positive regulation of cell migration
GO CC Complete:	microvillus, cilium, external side of plasma membrane, cell junction, Golgi apparatus, protein-containing complex, receptor complex, plasma membrane, nucleoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Signal Transduction, PIP3 activates AKT signaling, Signaling by Receptor Tyrosine Kinases, Downstream signal transduction, Intracellular signaling by second messengers, Signaling by PDGF, MAPK1/MAPK3 signaling, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, Negative regulation of the PI3K/AKT network, RAF/MAP kinase cascade, MAPK family signaling cascades

Orthologs

ID	Organism	Type
HUMAN\|HGNC=8803\|UniProtKB=P16234	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000016066.4\|UniProtKB=H2QPH4	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000010615.3\|UniProtKB=G3R4Z2	Gorilla gorilla gorilla	LDO
MOUSE\|MGI=MGI=97530\|UniProtKB=P26618	Mus musculus	LDO
RAT\|RGD=3284\|UniProtKB=P20786	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000007173.6\|UniProtKB=F1MX49	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000008841.6\|UniProtKB=A0A287AYB4	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000018176.4\|UniProtKB=F7A2X2	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000009141.6\|UniProtKB=M3WAV8	Felis catus	LDO
MONDO\|Ensembl=ENSMODG00000020670.3\|UniProtKB=F7E5I9	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000003786.3\|UniProtKB=F6V0P7	Ornithorhynchus anatinus	LDO
CHICK\|Gene=PDGFRA\|UniProtKB=Q9PUF6	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010013621.1\|UniProtKB=A0A8V0YKS4	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000010297.4\|UniProtKB=G1KK54	Anolis carolinensis	LDO
XENLA\|Gene=pdgfra.L\|UniProtKB=A0A1L8HTV1	Xenopus laevis	O
XENLA\|Gene=pdgfra\|UniProtKB=P26619	Xenopus laevis	LDO
XENLA\|Gene=pdgfra.S\|UniProtKB=A0A1L8HLA2	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-6072920\|UniProtKB=A4IHL2	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000019815.2\|UniProtKB=H2MZV1	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-990415-208\|UniProtKB=Q9DE49	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000014152.1\|UniProtKB=W5N9Y7	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000003493.3\|UniProtKB=F6TLX0	Ciona intestinalis	O
BRAFL\|Gene=LOC118418363\|UniProtKB=A0A9J7MV71	Branchiostoma floridae	O
BRAFL\|Gene=LOC118403946\|UniProtKB=A0A9J7HIK2	Branchiostoma floridae	O
BRAFL\|Gene=LOC118419709\|UniProtKB=A0A9J7LFS0	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC105444281\|UniProtKB=A0A7M7NBJ5	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105438002\|UniProtKB=A0A7M7NGH8	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC579430\|UniProtKB=A0A7M7NBH9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105437797\|UniProtKB=A0A7M7P5W9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115918442\|UniProtKB=A0A7M7NFV5	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC575248\|UniProtKB=A0A7M7NGI9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105443986\|UniProtKB=A0A7M7NDD9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC593142\|UniProtKB=A0A7M7PJZ3	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105445932\|UniProtKB=A0A7M7NC15	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105444011\|UniProtKB=A0A7M7NDZ4	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105443826\|UniProtKB=A0A7M7NBR9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105439256\|UniProtKB=A0A7M7NFB8	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100892684\|UniProtKB=A0A7M7NF85	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115921149\|UniProtKB=A0A7M7NC60	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105444275\|UniProtKB=A0A7M7ND25	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC590825\|UniProtKB=A0A7M7NBI9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100888196\|UniProtKB=A0A7M7LL81	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100888329\|UniProtKB=A0A7M7P467	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC579837\|UniProtKB=A0A7M7RCU0	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00017310\|UniProtKB=A0A2C9C3B4	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG19102\|UniProtKB=A8XUS9	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00103469\|UniProtKB=A0A2A6CRG6	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00008599\|UniProtKB=Q19238	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG05239\|UniProtKB=A8WZG4	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00107078\|UniProtKB=A0A2A6CZ19	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00002195\|UniProtKB=F3NWW5	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG22767\|UniProtKB=A8Y2V0	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00276578\|UniProtKB=A0A2A6B4J7	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00015087\|UniProtKB=Q10915	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG11187\|UniProtKB=A8XCN3	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00304683\|UniProtKB=A0A8R1Z946	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00011169\|UniProtKB=Q21868	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00002199\|UniProtKB=P34891	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00011339\|UniProtKB=O18008	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00002200\|UniProtKB=P34892	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG04906\|UniProtKB=A8WYS1	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG13386\|UniProtKB=A8XHW0	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG13385\|UniProtKB=A8XHW1	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00020678\|UniProtKB=A0A1I6CMA1	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG01733\|UniProtKB=A8WQZ3	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00021745\|UniProtKB=Q9N4T2	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00003862\|UniProtKB=Q17833	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00002211\|UniProtKB=O17955	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00003863\|UniProtKB=Q23677	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00011168\|UniProtKB=Q21867	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00012270\|UniProtKB=Q95ZK1	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00027499\|UniProtKB=A8WYS2	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG04913\|UniProtKB=A8WYS8	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00027448\|UniProtKB=A8WYM1	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00027500\|UniProtKB=A8WYS3	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00006897\|UniProtKB=Q21041	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00006894\|UniProtKB=G5ED65	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00006896\|UniProtKB=Q21038	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG17535\|UniProtKB=A8XR68	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG17536\|UniProtKB=A8XR69	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG17534\|UniProtKB=A8XR67	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00278186\|UniProtKB=A0A2A6B1V3	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00278185\|UniProtKB=A0A2A6B2E3	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0032006\|UniProtKB=E1JHB7	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP008813\|UniProtKB=A0A1S4GZA9	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC007584\|UniProtKB=A0A139WIY2	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_58385\|UniProtKB=E9H5T6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_305264\|UniProtKB=E9GQ40	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_48616\|UniProtKB=E9GD08	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_4284\|UniProtKB=E9GD15	Daphnia pulex	O
DAPPU\|Gene_ORFName=DAPPUDRAFT_44144\|UniProtKB=E9FZB6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_43719\|UniProtKB=E9FZF2	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_308023\|UniProtKB=E9H5G0	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_114299\|UniProtKB=E9HHQ5	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_130278\|UniProtKB=E9HM17	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_110024\|UniProtKB=E9H4Z3	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_325477\|UniProtKB=E9H4U6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_331276\|UniProtKB=E9HLZ6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_110251\|UniProtKB=E9H5G3	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_61463\|UniProtKB=E9HD20	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_119760\|UniProtKB=E9HZE7	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_302458\|UniProtKB=E9HNF0	Daphnia pulex	O
DAPPU\|Gene_ORFName=DAPPUDRAFT_48631\|UniProtKB=E9GCS3	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_108386\|UniProtKB=E9H018	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_53509\|UniProtKB=E9GQD0	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_308030\|UniProtKB=E9H5J0	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_253800\|UniProtKB=E9H5G1	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_58353\|UniProtKB=E9H5T9	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_64428\|UniProtKB=E9HNF3	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_302459\|UniProtKB=E9HNF4	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_130102\|UniProtKB=E9HGU7	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW005359\|UniProtKB=B7PKS1	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG133386\|UniProtKB=T1EI07	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG170959\|UniProtKB=T1F3M5	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG75629\|UniProtKB=T1G278	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG141355\|UniProtKB=T1EJ33	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG89500\|UniProtKB=T1G7D9	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g94990\|UniProtKB=A7RVU0	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g115371\|UniProtKB=A7SEI8	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g94997\|UniProtKB=A7RVT8	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g87486\|UniProtKB=A7RN88	Nematostella vectensis	O
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g87445\|UniProtKB=A7RN91	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG50752\|UniProtKB=B3S5N3	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG25090\|UniProtKB=B3RWV1	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_30176\|UniProtKB=A9VD80	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_2692\|UniProtKB=A9UPY9	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_27311\|UniProtKB=A9V4X6	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_34526\|UniProtKB=A9VCA3	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_33842\|UniProtKB=A9V7V7	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_33860\|UniProtKB=A9V7Z4	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_44299\|UniProtKB=A9V2D0	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_44298\|UniProtKB=A9UWK2	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_27155\|UniProtKB=A9V4G9	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_16001\|UniProtKB=A9UW70	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_27552\|UniProtKB=A9V5L8	Monosiga brevicollis	O