PANTHER Gene Information

Gene Symbol(s):

GCH1

Organism:

Canis lupus familiaris

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Gene Name:

GTP cyclohydrolase 1

Gene ID:

ENSCAFG00845014724.1

Protein ID:

A0A8I3NRN2

Persistent Id:

PTN008961297

Alternate Ids:

A0A8I3NRN2(Synonym)	A0A8I3NRN2_CANLF(UniProtKB-ID)
ENSCAFT00845026336(Ensembl_TRS)	ENSCAFG00845014724(Ensembl)
ENSCAFP00845020762(Ensembl_PRO)
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PANTHER Classification

PANTHER Family:	GTP CYCLOHYDROLASE I (PTHR11109)
PANTHER Subfamily:	GTP CYCLOHYDROLASE 1 (PTHR11109:SF11)
PANTHER GO-slim Molecular Function:	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines nucleotide binding zinc ion binding carbohydrate derivative binding anion binding
PANTHER GO-slim Biological Process:	organic cyclic compound biosynthetic process cellular nitrogen compound biosynthetic process aromatic compound biosynthetic process organonitrogen compound biosynthetic process heterocycle biosynthetic process alcohol biosynthetic process
PANTHER GO-slim Cellular Component:	cytoplasm
PANTHER protein class:	hydrolase

Pathway Categories:

Tetrahydrofolate biosynthesis

GTP cyclohydrolase I

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	GTP binding, zinc ion binding, GTP cyclohydrolase I activity
GO BP Complete:	tetrahydrobiopterin biosynthetic process, tetrahydrofolate biosynthetic process
GO CC Complete:	nucleus, cytoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation, Metabolism of cofactors, Metabolism, Metabolism of vitamins and cofactors

Orthologs

ID	Organism	Type
HUMAN\|HGNC=4193\|UniProtKB=P30793	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000006365.6\|UniProtKB=H2RBI2	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000011080.3\|UniProtKB=G3R664	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000004084.4\|UniProtKB=F6ZD19	Macaca mulatta	LDO
MOUSE\|MGI=MGI=95675\|UniProtKB=Q05915	Mus musculus	LDO
RAT\|RGD=61992\|UniProtKB=P22288	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000040151.3\|UniProtKB=F1MZ14	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000035715.3\|UniProtKB=A0A287BGL7	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000015025.4\|UniProtKB=F7D260	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000042127.2\|UniProtKB=A0A337SSI1	Felis catus	LDO
MONDO\|Ensembl=ENSMODG00000011684.3\|UniProtKB=F7GE69	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000011384.2\|UniProtKB=A0A6I8NQ73	Ornithorhynchus anatinus	LDO
CHICK\|Gene=GCH1\|UniProtKB=P50141	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010018806.1\|UniProtKB=F1NEK8	Gallus gallus	LDO
XENLA\|Gene=LOC108699789\|UniProtKB=A0A1L8F0D4	Xenopus laevis	O
XENLA\|Gene=LOC108698762\|UniProtKB=A0A1L8F9V0	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-961365\|UniProtKB=F7AIS0	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000023979.1\|UniProtKB=A0A3B3I3A1	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-070720-5\|UniProtKB=E7FGQ8	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000012096.1\|UniProtKB=W5N2M9	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000004358.3\|UniProtKB=F7B4P8	Ciona intestinalis	O
BRAFL\|Gene=LOC118416072\|UniProtKB=A0A9J7L6P2	Branchiostoma floridae	O
BRAFL\|Gene=LOC118421325\|UniProtKB=A0A9J7MZE8	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC580182\|UniProtKB=A0A7M7PCZ8	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115927655\|UniProtKB=A0A7M7PDU0	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC583737\|UniProtKB=A0A7M7TGQ2	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00000298\|UniProtKB=Q19980	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00031200\|UniProtKB=A8X8K8	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00091395\|UniProtKB=A0A454XZQ3	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0003162\|UniProtKB=P48596	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP006441\|UniProtKB=Q7Q5H2	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC010564\|UniProtKB=D2CFW6	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_442958\|UniProtKB=E9G1C2	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW006982\|UniProtKB=B7PWM4	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG187204\|UniProtKB=T1FP76	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g199909\|UniProtKB=A7RNY6	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG19344\|UniProtKB=B3RJS9	Trichoplax adhaerens	O
YEAST\|SGD=S000003499\|UniProtKB=P51601	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_AGR335C\|UniProtKB=Q74Z71	Eremothecium gossypii	O
CANAL\|CGD=CAL0000195996\|UniProtKB=A0A1D8PP19	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_A10310g\|UniProtKB=Q6CHC2	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_08188\|UniProtKB=C8V749	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_5G03140\|UniProtKB=Q4WEI6	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU07774\|UniProtKB=P51599	Neurospora crassa	O
SCLS1\|Gene_ORFName=SS1G_09610\|UniProtKB=A7EWA1	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_11256\|UniProtKB=Q0UAF8	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPAC17A5.13\|UniProtKB=O13774	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_03275\|UniProtKB=B6K3T4	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNB04920\|UniProtKB=Q5KLK7	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_12048\|UniProtKB=A0A0D1CFD1	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_19999\|UniProtKB=E3LBL4	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_9124\|UniProtKB=F4NTC0	Batrachochytrium dendrobatidis	O
DICDI\|dictyBase=DDB_G0288481\|UniProtKB=Q94465	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_158224\|UniProtKB=F1A141	Dictyostelium purpureum	O
PLAF7\|EnsemblGenome=PF3D7_1224000\|UniProtKB=Q8I5H7	Plasmodium falciparum	O
THAPS\|EnsemblGenome=THAPSDRAFT_26931\|UniProtKB=B8BTH5	Thalassiosira pseudonana	O
PHYRM\|Gene=H3G797_PHYRM\|UniProtKB=H3G797	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_09g393913v5\|UniProtKB=A0A2K3DEE6	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00013p00256210\|UniProtKB=W1PS39	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_56G00650\|UniProtKB=A0A0K9NVP6	Zostera marina	O
MUSAM\|EnsemblGenome=Ma08_g00920\|UniProtKB=A0A804K1J6	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma08_g08510\|UniProtKB=A0A804K4B8	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma11_g13950\|UniProtKB=A0A804L7M2	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_021939mg\|UniProtKB=K3Z5X1	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3006G254100\|UniProtKB=A0A1B6PNW7	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb432940\|UniProtKB=B4FH02	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb067370\|UniProtKB=A0A1D6DUT0	Zea mays	O
BRADI\|EnsemblGenome=BRADI_5g25070v3\|UniProtKB=I1J2Z7	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.2HG0201250\|UniProtKB=A0A8I7B412	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS2A02G492900\|UniProtKB=A0A3B6B7C8	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2D02G493100\|UniProtKB=A0A3B6DP21	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2B02G521000\|UniProtKB=B0EVI8	Triticum aestivum	O
NELNU\|Gene=LOC104594279\|UniProtKB=A0A1U7ZUY4	Nelumbo nucifera	O
NELNU\|Gene=LOC104587520\|UniProtKB=A0A1U7YVT9	Nelumbo nucifera	O
SPIOL\|Gene=LOC110803219\|UniProtKB=A0A9R0JC07	Spinacia oleracea	O
SPIOL\|Gene=LOC110803227\|UniProtKB=A0A9R0JAS1	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr01g0023231\|UniProtKB=A0A251VP27	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C900460850\|UniProtKB=A0A9R1UKW4	Lactuca sativa	O
LACSA\|Gene_ORFName=LSAT_V11C500294000\|UniProtKB=A0A9R1X9Y0	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a007442mg\|UniProtKB=A0A022RKV4	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_18355\|UniProtKB=A0A2G2ZE69	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400020105\|UniProtKB=M1BS83	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc06g083230.3\|UniProtKB=Q8VYU3	Solanum lycopersicum	O
TOBAC\|Gene=LOC107792598\|UniProtKB=A0A1S4A0V9	Nicotiana tabacum	O
TOBAC\|Gene=LOC107759240\|UniProtKB=A0A1S3WYB9	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi03g00900\|UniProtKB=F6HJF9	Vitis vinifera	O
VITVI\|EnsemblGenome=Vitvi01g01031\|UniProtKB=F6HPQ1	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_H00758\|UniProtKB=A0A059AX69	Eucalyptus grandis	O
BRANA\|Gene_ORFName=GSBRNA2T00098103001\|UniProtKB=A0A078IMA2	Brassica napus	O
BRACM\|EnsemblGenome=Bra020689\|UniProtKB=M4DVZ5	Brassica campestris	O
BRANA\|Gene_ORFName=DARMORV10_A05P40970.1\|UniProtKB=A0A078GH72	Brassica napus	O
BRANA\|Gene_ORFName=DARMORV10_C05P60090.1\|UniProtKB=A0A078GTW6	Brassica napus	O
BRACM\|EnsemblGenome=Bra029634\|UniProtKB=M4ELG6	Brassica campestris	O
BRANA\|Gene_ORFName=GSBRNA2T00057481001\|UniProtKB=A0A078HBS9	Brassica napus	O
BRACM\|EnsemblGenome=Bra040368\|UniProtKB=M4FGZ0	Brassica campestris	O
ARATH\|TAIR=locus=2098525\|UniProtKB=Q9SFV7	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107955397\|UniProtKB=A0A1U8P8P9	Gossypium hirsutum	O
GOSHI\|Gene=LOC107954960\|UniProtKB=A0A1U8P4I9	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_002762\|UniProtKB=A0A061DP08	Theobroma cacao	O
POPTR\|EnsemblGenome=POPTR_002G247100v3\|UniProtKB=B9GQM6	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_014G195000v3\|UniProtKB=B9IBE3	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_12G049200\|UniProtKB=A0A251JLK0	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_1416900\|UniProtKB=B9SYL5	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_03G085500\|UniProtKB=I1JM61	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_03G085100\|UniProtKB=K7KDU1	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_16G089300\|UniProtKB=K7MG23	Glycine max	O
MEDTR\|EnsemblGenome=MTR_8g016030\|UniProtKB=A0A072TNB0	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_8g012570\|UniProtKB=A0A072TL11	Medicago truncatula	O
SOYBN\|EnsemblGenome=GLYMA_18G158900\|UniProtKB=K7MSK2	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_08G347400\|UniProtKB=I1KZ27	Glycine max	O
MEDTR\|EnsemblGenome=MTR_7g055700\|UniProtKB=G7L058	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr05_05310\|UniProtKB=A0A2I4H162	Juglans regia	O
JUGRE\|EnsemblGenome=Jr14_06160\|UniProtKB=A0A2I4GJW6	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_7G351870\|UniProtKB=A0A0A0K578	Cucumis sativus	O
CUCSA\|EnsemblGenome=Csa_1G597180\|UniProtKB=A0A0A0LWQ6	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_8G196500\|UniProtKB=M5W5Y8	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_267473\|UniProtKB=D8RJ88	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_76344\|UniProtKB=D8QRM4	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c11_25080\|UniProtKB=A0A2K1JW72	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c7_8060\|UniProtKB=A0A7I4E9I3	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0054s0102\|UniProtKB=A0A2R6WVX4	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_001750040\|UniProtKB=A0A1Y1I5R2	Klebsormidium nitens	O
NITMS\|EnsemblGenome=Nmar_0038\|UniProtKB=A9A529	Nitrosopumilus maritimus	O
SACS2\|EnsemblGenome=SSO0364\|UniProtKB=Q980E8	Sulfolobus solfataricus	O
PYRAE\|EnsemblGenome=PAE1588\|UniProtKB=Q8ZWW5	Pyrobaculum aerophilum	O
CHLAA\|EnsemblGenome=Caur_2641\|UniProtKB=A9WIX0	Chloroflexus aurantiacus	O
STRCO\|Gene_OrderedLocusName=SCO3403\|UniProtKB=Q9X8I3	Streptomyces coelicolor	O
MYCTU\|Gene_OrderedLocusName=Rv3609c\|UniProtKB=P9WN57	Mycobacterium tuberculosis	O
CLOBH\|Gene_OrderedLocusName=CBO1556\|UniProtKB=A5I231	Clostridium botulinum	O
STRR6\|EnsemblGenome=spr0268\|UniProtKB=P59656	Streptococcus pneumoniae	O
LISMO\|EnsemblGenome=CAD00011\|UniProtKB=Q8Y5X1	Listeria monocytogenes	O
BACSU\|EnsemblGenome=BSU_22780\|UniProtKB=P19465	Bacillus subtilis	O
BACCR\|EnsemblGenome=BC_1511\|UniProtKB=Q81FQ8	Bacillus cereus	O
DEIRA\|EnsemblGenome=DR_0036\|UniProtKB=Q9RYB4	Deinococcus radiodurans	O
GLOVI\|EnsemblGenome=BAC89521\|UniProtKB=Q7NK98	Gloeobacter violaceus	O
SYNY3\|EnsemblGenome=BAA10406\|UniProtKB=Q55759	Synechocystis	O
LEPIN\|EnsemblGenome=LA_4255\|UniProtKB=Q8EYG1	Leptospira interrogans	O
BACTN\|EnsemblGenome=BT_3931\|UniProtKB=Q8A0U0	Bacteroides thetaiotaomicron	O
RHOBA\|EnsemblGenome=RB11853\|UniProtKB=Q7UJJ7	Rhodopirellula baltica	O
AQUAE\|EnsemblGenome=aq_239\|UniProtKB=O66603	Aquifex aeolicus	O
THEYD\|EnsemblGenome=THEYE_A0673\|UniProtKB=B5YJV0	Thermodesulfovibrio yellowstonii	O
FUSNN\|EnsemblGenome=FN0071\|UniProtKB=Q8RH43	Fusobacterium nucleatum	O
HELPY\|EnsemblGenome=HP_0928\|UniProtKB=P56462	Helicobacter pylori	O
BRADU\|EnsemblGenome=BAC50787\|UniProtKB=Q89IW2	Bradyrhizobium diazoefficiens	O
COXBU\|EnsemblGenome=CBU_0795\|UniProtKB=Q83DE3	Coxiella burnetii	O
HAEIN\|EnsemblGenome=HI_1447\|UniProtKB=P43866	Haemophilus influenzae	O
SHEON\|Gene_OrderedLocusName=SO_4254\|UniProtKB=Q8E9L6	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_A0616\|UniProtKB=Q9KLX5	Vibrio cholerae	O
XANCP\|EnsemblGenome=XCC4166\|UniProtKB=Q8P3B0	Xanthomonas campestris	O
PSEAE\|EnsemblGenome=PA1674\|UniProtKB=Q9I351	Pseudomonas aeruginosa	O
PSEAE\|EnsemblGenome=PA3438\|UniProtKB=Q9HYG8	Pseudomonas aeruginosa	O
SALTY\|EnsemblGenome=STM2193\|UniProtKB=P64209	Salmonella typhimurium	O
YERPE\|EnsemblGenome=YP_1395\|UniProtKB=Q8ZG15	Yersinia pestis	O
ECOLI\|EnsemblGenome=BAE76630\|UniProtKB=P0A6T5	Escherichia coli	O