PANTHER Gene Information

Gene Symbol(s):

Organism:

Gorilla gorilla gorilla

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Gene Name:

GTP cyclohydrolase 1

Gene ID:

ENSGGOG00000011080.3

Protein ID:

G3R664

Persistent Id:

PTN002595729

Alternate Ids:

ENSGGOG00000011080(Ensembl)	ENSGGOP00000010803(Ensembl_PRO)
ENSGGOT00000011124(Ensembl_TRS)	CABD030092409(EMBL)
G3R664_GORGO(UniProtKB-ID)	G3R664(Synonym)
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PANTHER Classification

PANTHER Family:	GTP CYCLOHYDROLASE I (PTHR11109)
PANTHER Subfamily:	GTP CYCLOHYDROLASE 1 (PTHR11109:SF11)
PANTHER GO-slim Molecular Function:	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines nucleotide binding zinc ion binding carbohydrate derivative binding anion binding
PANTHER GO-slim Biological Process:	organic cyclic compound biosynthetic process cellular nitrogen compound biosynthetic process aromatic compound biosynthetic process organonitrogen compound biosynthetic process heterocycle biosynthetic process alcohol biosynthetic process
PANTHER GO-slim Cellular Component:	cytoplasm
PANTHER protein class:	hydrolase

Pathway Categories:

Tetrahydrofolate biosynthesis

GTP cyclohydrolase I

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	GTP binding, zinc ion binding, identical protein binding, protein homodimerization activity, GTP cyclohydrolase I activity, GTPase activity, mitogen-activated protein kinase binding, hydrolase activity
GO BP Complete:	positive regulation of heart rate, dopamine biosynthetic process, pteridine-containing compound biosynthetic process, neuromuscular process controlling posture, tetrahydrobiopterin biosynthetic process, regulation of lung blood pressure, response to type II interferon, response to lipopolysaccharide, tetrahydrofolate biosynthetic process, regulation of removal of superoxide radicals, regulation of blood pressure, response to tumor necrosis factor
GO CC Complete:	nucleus, nuclear membrane, cytoplasm, cytosol, cytoplasmic vesicle, protein-containing complex, nucleoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=4193\|UniProtKB=P30793	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000006365.6\|UniProtKB=H2RBI2	Pan troglodytes	LDO
MACMU\|Ensembl=ENSMMUG00000004084.4\|UniProtKB=F6ZD19	Macaca mulatta	LDO
MOUSE\|MGI=MGI=95675\|UniProtKB=Q05915	Mus musculus	LDO
RAT\|RGD=61992\|UniProtKB=P22288	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000040151.3\|UniProtKB=F1MZ14	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000035715.3\|UniProtKB=A0A287BGL7	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000015025.4\|UniProtKB=F7D260	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000042127.2\|UniProtKB=A0A337SSI1	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845014724.1\|UniProtKB=A0A8I3NRN2	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000011684.3\|UniProtKB=F7GE69	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000011384.2\|UniProtKB=A0A6I8NQ73	Ornithorhynchus anatinus	LDO
CHICK\|Gene=GCH1\|UniProtKB=P50141	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010018806.1\|UniProtKB=F1NEK8	Gallus gallus	LDO
XENLA\|Gene=LOC108699789\|UniProtKB=A0A1L8F0D4	Xenopus laevis	O
XENLA\|Gene=LOC108698762\|UniProtKB=A0A1L8F9V0	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-961365\|UniProtKB=F7AIS0	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000023979.1\|UniProtKB=A0A3B3I3A1	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-070720-5\|UniProtKB=E7FGQ8	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000012096.1\|UniProtKB=W5N2M9	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000004358.3\|UniProtKB=F7B4P8	Ciona intestinalis	O
BRAFL\|Gene=LOC118416072\|UniProtKB=A0A9J7L6P2	Branchiostoma floridae	O
BRAFL\|Gene=LOC118421325\|UniProtKB=A0A9J7MZE8	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC580182\|UniProtKB=A0A7M7PCZ8	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115927655\|UniProtKB=A0A7M7PDU0	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC583737\|UniProtKB=A0A7M7TGQ2	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00000298\|UniProtKB=Q19980	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00031200\|UniProtKB=A8X8K8	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00091395\|UniProtKB=A0A454XZQ3	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0003162\|UniProtKB=P48596	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP006441\|UniProtKB=Q7Q5H2	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC010564\|UniProtKB=D2CFW6	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_442958\|UniProtKB=E9G1C2	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW006982\|UniProtKB=B7PWM4	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG187204\|UniProtKB=T1FP76	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g199909\|UniProtKB=A7RNY6	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG19344\|UniProtKB=B3RJS9	Trichoplax adhaerens	O
YEAST\|SGD=S000003499\|UniProtKB=P51601	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_AGR335C\|UniProtKB=Q74Z71	Eremothecium gossypii	O
CANAL\|CGD=CAL0000195996\|UniProtKB=A0A1D8PP19	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_A10310g\|UniProtKB=Q6CHC2	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_08188\|UniProtKB=C8V749	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_5G03140\|UniProtKB=Q4WEI6	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU07774\|UniProtKB=P51599	Neurospora crassa	O
SCLS1\|Gene_ORFName=SS1G_09610\|UniProtKB=A7EWA1	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_11256\|UniProtKB=Q0UAF8	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPAC17A5.13\|UniProtKB=O13774	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_03275\|UniProtKB=B6K3T4	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNB04920\|UniProtKB=Q5KLK7	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_12048\|UniProtKB=A0A0D1CFD1	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_19999\|UniProtKB=E3LBL4	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_9124\|UniProtKB=F4NTC0	Batrachochytrium dendrobatidis	O
DICDI\|dictyBase=DDB_G0288481\|UniProtKB=Q94465	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_158224\|UniProtKB=F1A141	Dictyostelium purpureum	O
PLAF7\|EnsemblGenome=PF3D7_1224000\|UniProtKB=Q8I5H7	Plasmodium falciparum	O
THAPS\|EnsemblGenome=THAPSDRAFT_26931\|UniProtKB=B8BTH5	Thalassiosira pseudonana	O
PHYRM\|Gene=H3G797_PHYRM\|UniProtKB=H3G797	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_09g393913v5\|UniProtKB=A0A2K3DEE6	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00013p00256210\|UniProtKB=W1PS39	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_56G00650\|UniProtKB=A0A0K9NVP6	Zostera marina	O
MUSAM\|EnsemblGenome=Ma08_g00920\|UniProtKB=A0A804K1J6	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma08_g08510\|UniProtKB=A0A804K4B8	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma11_g13950\|UniProtKB=A0A804L7M2	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_021939mg\|UniProtKB=K3Z5X1	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3006G254100\|UniProtKB=A0A1B6PNW7	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb432940\|UniProtKB=B4FH02	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb067370\|UniProtKB=A0A1D6DUT0	Zea mays	O
BRADI\|EnsemblGenome=BRADI_5g25070v3\|UniProtKB=I1J2Z7	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.2HG0201250\|UniProtKB=A0A8I7B412	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS2A02G492900\|UniProtKB=A0A3B6B7C8	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2D02G493100\|UniProtKB=A0A3B6DP21	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2B02G521000\|UniProtKB=B0EVI8	Triticum aestivum	O
NELNU\|Gene=LOC104594279\|UniProtKB=A0A1U7ZUY4	Nelumbo nucifera	O
NELNU\|Gene=LOC104587520\|UniProtKB=A0A1U7YVT9	Nelumbo nucifera	O
SPIOL\|Gene=LOC110803219\|UniProtKB=A0A9R0JC07	Spinacia oleracea	O
SPIOL\|Gene=LOC110803227\|UniProtKB=A0A9R0JAS1	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr01g0023231\|UniProtKB=A0A251VP27	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C900460850\|UniProtKB=A0A9R1UKW4	Lactuca sativa	O
LACSA\|Gene_ORFName=LSAT_V11C500294000\|UniProtKB=A0A9R1X9Y0	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a007442mg\|UniProtKB=A0A022RKV4	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_18355\|UniProtKB=A0A2G2ZE69	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400020105\|UniProtKB=M1BS83	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc06g083230.3\|UniProtKB=Q8VYU3	Solanum lycopersicum	O
TOBAC\|Gene=LOC107792598\|UniProtKB=A0A1S4A0V9	Nicotiana tabacum	O
TOBAC\|Gene=LOC107759240\|UniProtKB=A0A1S3WYB9	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi03g00900\|UniProtKB=F6HJF9	Vitis vinifera	O
VITVI\|EnsemblGenome=Vitvi01g01031\|UniProtKB=F6HPQ1	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_H00758\|UniProtKB=A0A059AX69	Eucalyptus grandis	O
BRANA\|Gene_ORFName=GSBRNA2T00098103001\|UniProtKB=A0A078IMA2	Brassica napus	O
BRACM\|EnsemblGenome=Bra020689\|UniProtKB=M4DVZ5	Brassica campestris	O
BRANA\|Gene_ORFName=DARMORV10_A05P40970.1\|UniProtKB=A0A078GH72	Brassica napus	O
BRANA\|Gene_ORFName=DARMORV10_C05P60090.1\|UniProtKB=A0A078GTW6	Brassica napus	O
BRACM\|EnsemblGenome=Bra029634\|UniProtKB=M4ELG6	Brassica campestris	O
BRANA\|Gene_ORFName=GSBRNA2T00057481001\|UniProtKB=A0A078HBS9	Brassica napus	O
BRACM\|EnsemblGenome=Bra040368\|UniProtKB=M4FGZ0	Brassica campestris	O
ARATH\|TAIR=locus=2098525\|UniProtKB=Q9SFV7	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107955397\|UniProtKB=A0A1U8P8P9	Gossypium hirsutum	O
GOSHI\|Gene=LOC107954960\|UniProtKB=A0A1U8P4I9	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_002762\|UniProtKB=A0A061DP08	Theobroma cacao	O
POPTR\|EnsemblGenome=POPTR_002G247100v3\|UniProtKB=B9GQM6	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_014G195000v3\|UniProtKB=B9IBE3	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_12G049200\|UniProtKB=A0A251JLK0	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_1416900\|UniProtKB=B9SYL5	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_03G085500\|UniProtKB=I1JM61	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_03G085100\|UniProtKB=K7KDU1	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_16G089300\|UniProtKB=K7MG23	Glycine max	O
MEDTR\|EnsemblGenome=MTR_8g016030\|UniProtKB=A0A072TNB0	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_8g012570\|UniProtKB=A0A072TL11	Medicago truncatula	O
SOYBN\|EnsemblGenome=GLYMA_18G158900\|UniProtKB=K7MSK2	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_08G347400\|UniProtKB=I1KZ27	Glycine max	O
MEDTR\|EnsemblGenome=MTR_7g055700\|UniProtKB=G7L058	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr05_05310\|UniProtKB=A0A2I4H162	Juglans regia	O
JUGRE\|EnsemblGenome=Jr14_06160\|UniProtKB=A0A2I4GJW6	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_7G351870\|UniProtKB=A0A0A0K578	Cucumis sativus	O
CUCSA\|EnsemblGenome=Csa_1G597180\|UniProtKB=A0A0A0LWQ6	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_8G196500\|UniProtKB=M5W5Y8	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_267473\|UniProtKB=D8RJ88	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_76344\|UniProtKB=D8QRM4	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c11_25080\|UniProtKB=A0A2K1JW72	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c7_8060\|UniProtKB=A0A7I4E9I3	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0054s0102\|UniProtKB=A0A2R6WVX4	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_001750040\|UniProtKB=A0A1Y1I5R2	Klebsormidium nitens	O
NITMS\|EnsemblGenome=Nmar_0038\|UniProtKB=A9A529	Nitrosopumilus maritimus	O
SACS2\|EnsemblGenome=SSO0364\|UniProtKB=Q980E8	Sulfolobus solfataricus	O
PYRAE\|EnsemblGenome=PAE1588\|UniProtKB=Q8ZWW5	Pyrobaculum aerophilum	O
CHLAA\|EnsemblGenome=Caur_2641\|UniProtKB=A9WIX0	Chloroflexus aurantiacus	O
STRCO\|Gene_OrderedLocusName=SCO3403\|UniProtKB=Q9X8I3	Streptomyces coelicolor	O
MYCTU\|Gene_OrderedLocusName=Rv3609c\|UniProtKB=P9WN57	Mycobacterium tuberculosis	O
CLOBH\|Gene_OrderedLocusName=CBO1556\|UniProtKB=A5I231	Clostridium botulinum	O
STRR6\|EnsemblGenome=spr0268\|UniProtKB=P59656	Streptococcus pneumoniae	O
LISMO\|EnsemblGenome=CAD00011\|UniProtKB=Q8Y5X1	Listeria monocytogenes	O
BACSU\|EnsemblGenome=BSU_22780\|UniProtKB=P19465	Bacillus subtilis	O
BACCR\|EnsemblGenome=BC_1511\|UniProtKB=Q81FQ8	Bacillus cereus	O
DEIRA\|EnsemblGenome=DR_0036\|UniProtKB=Q9RYB4	Deinococcus radiodurans	O
GLOVI\|EnsemblGenome=BAC89521\|UniProtKB=Q7NK98	Gloeobacter violaceus	O
SYNY3\|EnsemblGenome=BAA10406\|UniProtKB=Q55759	Synechocystis	O
LEPIN\|EnsemblGenome=LA_4255\|UniProtKB=Q8EYG1	Leptospira interrogans	O
BACTN\|EnsemblGenome=BT_3931\|UniProtKB=Q8A0U0	Bacteroides thetaiotaomicron	O
RHOBA\|EnsemblGenome=RB11853\|UniProtKB=Q7UJJ7	Rhodopirellula baltica	O
AQUAE\|EnsemblGenome=aq_239\|UniProtKB=O66603	Aquifex aeolicus	O
THEYD\|EnsemblGenome=THEYE_A0673\|UniProtKB=B5YJV0	Thermodesulfovibrio yellowstonii	O
FUSNN\|EnsemblGenome=FN0071\|UniProtKB=Q8RH43	Fusobacterium nucleatum	O
HELPY\|EnsemblGenome=HP_0928\|UniProtKB=P56462	Helicobacter pylori	O
BRADU\|EnsemblGenome=BAC50787\|UniProtKB=Q89IW2	Bradyrhizobium diazoefficiens	O
COXBU\|EnsemblGenome=CBU_0795\|UniProtKB=Q83DE3	Coxiella burnetii	O
HAEIN\|EnsemblGenome=HI_1447\|UniProtKB=P43866	Haemophilus influenzae	O
SHEON\|Gene_OrderedLocusName=SO_4254\|UniProtKB=Q8E9L6	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_A0616\|UniProtKB=Q9KLX5	Vibrio cholerae	O
XANCP\|EnsemblGenome=XCC4166\|UniProtKB=Q8P3B0	Xanthomonas campestris	O
PSEAE\|EnsemblGenome=PA1674\|UniProtKB=Q9I351	Pseudomonas aeruginosa	O
PSEAE\|EnsemblGenome=PA3438\|UniProtKB=Q9HYG8	Pseudomonas aeruginosa	O
SALTY\|EnsemblGenome=STM2193\|UniProtKB=P64209	Salmonella typhimurium	O
YERPE\|EnsemblGenome=YP_1395\|UniProtKB=Q8ZG15	Yersinia pestis	O
ECOLI\|EnsemblGenome=BAE76630\|UniProtKB=P0A6T5	Escherichia coli	O