PANTHER Gene Information

Gene Symbol(s):

GDF15

Organism:

Canis lupus familiaris

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Gene Name:

Growth differentiation factor 15

Gene ID:

ENSCAFG00845022411.1

Protein ID:

A0A8I3PB42

Persistent Id:

PTN000218473

Alternate Ids:

A0A8I3PB42_CANLF(UniProtKB-ID)	ENSCAFT00845039545(Ensembl_TRS)
A0A8I3PB42(Synonym)	ENSCAFP00845030989(Ensembl_PRO)
ENSCAFG00845022411(Ensembl)
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PANTHER Classification

PANTHER Family:	TGF-BETA FAMILY (PTHR11848)
PANTHER Subfamily:	GROWTH_DIFFERENTIATION FACTOR 15 (PTHR11848:SF78)
PANTHER GO-slim Molecular Function:	cytokine activity
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:	extracellular space
PANTHER protein class:	growth factor

Pathway Categories:

TGF-beta signaling pathway

Transforming growth factor beta

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	growth factor activity, protein homodimerization activity, cytokine activity, hormone activity
GO BP Complete:	negative regulation of multicellular organism growth, negative regulation of SMAD protein signal transduction, negative regulation of appetite, cellular response to chemical stress, positive regulation of myoblast fusion, positive regulation of MAPK cascade, negative regulation of growth hormone receptor signaling pathway, response to metformin, reduction of food intake in response to dietary excess, negative regulation of leukocyte migration, positive regulation of fatty acid oxidation, GDF15-GFRAL signaling pathway, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO CC Complete:	nucleus, extracellular space, Golgi apparatus

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=30142\|UniProtKB=Q99988	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000010707.4\|UniProtKB=H2QFT1	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000016924.3\|UniProtKB=G3RL77	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000050122.1\|UniProtKB=A0A5F7ZP77	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1346047\|UniProtKB=Q9Z0J7	Mus musculus	LDO
RAT\|RGD=2674\|UniProtKB=Q9Z0J6	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000015618.6\|UniProtKB=E1BBL5	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000034260.2\|UniProtKB=D3Y269	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000039579.2\|UniProtKB=A0A3Q2GZK8	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000009733.4\|UniProtKB=M3WC01	Felis catus	LDO
MONDO\|Ensembl=ENSMODG00000023947.3\|UniProtKB=A0A5F8HDP5	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000001923.2\|UniProtKB=A0A6I8NY58	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010027172.1\|UniProtKB=A0A8V1AF44	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000040409.1\|UniProtKB=A0A803TDR7	Anolis carolinensis	LDO
XENLA\|Gene=gdf15.L\|UniProtKB=A0A8J0V1Q7	Xenopus laevis	O
XENLA\|Gene=gdf15.S\|UniProtKB=A0A1L8HNP6	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-5714902\|UniProtKB=A0A803JR63	Xenopus tropicalis	LDO
DANRE\|Gene=LOC101886665\|UniProtKB=A0A8M9PIY4	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000007803.1\|UniProtKB=W5MM58	lepisosteus oculatus	O
LEPOC\|Ensembl=ENSLOCG00000001470.1\|UniProtKB=W5LZX5	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118423922\|UniProtKB=A0A9J7N3A4	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC100147806\|UniProtKB=B2YGG4	Strongylocentrotus purpuratus	O
CAEEL\|Gene_ORFName=CELE_Y46E12BL.1\|UniProtKB=A0A8S4QGI4	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG20656\|UniProtKB=A8XYB0	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00107742\|UniProtKB=A0A2A6C891	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00278464\|UniProtKB=A0A454Y4J7	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00272968\|UniProtKB=A0A454XJT7	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00273955\|UniProtKB=A0A2A6B6K2	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00096903\|UniProtKB=A0A2A6C8S7	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0024913\|UniProtKB=O61643	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP000342\|UniProtKB=A0A1S4G8N6	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC015808\|UniProtKB=D2A422	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_305466\|UniProtKB=E9FWU5	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW008819\|UniProtKB=B7PZ52	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW016200\|UniProtKB=B7P4B4	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG111242\|UniProtKB=T1EF97	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g196852\|UniProtKB=A7RGJ4	Nematostella vectensis	O