PANTHER Gene Information

Gene Symbol(s):

C1R

Organism:

Canis lupus familiaris

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Gene Name:

Complement C1r

Gene ID:

ENSCAFG00845025120.1

Protein ID:

A0A8I3PJQ7

Persistent Id:

PTN009088522

Alternate Ids:

ENSCAFG00845025120(Ensembl)	ENSCAFT00845044332(Ensembl_TRS)
A0A8I3PJQ7_CANLF(UniProtKB-ID)	ENSCAFP00845034737(Ensembl_PRO)
A0A8I3PJQ7(Synonym)
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PANTHER Classification

PANTHER Family:	COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED (PTHR24255)
PANTHER Subfamily:	COMPLEMENT C1R SUBCOMPONENT (PTHR24255:SF25)
PANTHER GO-slim Molecular Function:	serine-type endopeptidase activity
PANTHER GO-slim Biological Process:	zymogen activation
PANTHER GO-slim Cellular Component:	extracellular space
PANTHER protein class:	serine protease

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	calcium ion binding, serine-type endopeptidase activity
GO BP Complete:	zymogen activation, complement activation, classical pathway, innate immune response, proteolysis
GO CC Complete:	extracellular space, blood microparticle, extracellular region

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Innate Immune System, Initial triggering of complement, Creation of C4 and C2 activators, Immune System, Classical antibody-mediated complement activation, Regulation of Complement cascade, Complement cascade

Orthologs

ID	Organism	Type
HUMAN\|HGNC=1246\|UniProtKB=P00736	Homo sapiens	LDO
PANTR\|Gene=C1R\|UniProtKB=Q5R1W3	Pan troglodytes	O
PANTR\|Ensembl=ENSPTRG00000004606.7\|UniProtKB=H2RB01	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000039052.1\|UniProtKB=A0A2I2ZAV7	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000006470.4\|UniProtKB=H9FZ50	Macaca mulatta	LDO
MOUSE\|MGI=MGI=3779804\|UniProtKB=Q8CFG9	Mus musculus	O
MOUSE\|MGI=MGI=1355313\|UniProtKB=Q8CG16	Mus musculus	LDO
RAT\|RGD=1309091\|UniProtKB=B5DEH7	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000008612.5\|UniProtKB=A5D9E9	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000060530.1\|UniProtKB=A0A480RJC3	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000021429.4\|UniProtKB=A0A9L0SLY6	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000045616.2\|UniProtKB=A0A337SDE6	Felis catus	O
FELCA\|Ensembl=ENSFCAG00000000177.6\|UniProtKB=M3VU82	Felis catus	LDO
MONDO\|Ensembl=ENSMODG00000018171.4\|UniProtKB=F7BU27	Monodelphis domestica	LDO
CHICK\|Ensembl=ENSGALG00010023655.1\|UniProtKB=A0A8V0ZNL2	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000007262.4\|UniProtKB=H9GCQ9	Anolis carolinensis	LDO
XENLA\|Gene=c1r.L\|UniProtKB=Q6GLK4	Xenopus laevis	O
XENTR\|Gene=LOC116406517\|UniProtKB=A0A8J1JZ09	Xenopus tropicalis	O
XENLA\|Gene=MGC130869.L\|UniProtKB=Q2VPN1	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-995376\|UniProtKB=A0A8J0QSW6	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000012367.2\|UniProtKB=H2MAD0	Oryzias latipes	O
LEPOC\|Ensembl=ENSLOCG00000007599.1\|UniProtKB=W5MLG1	lepisosteus oculatus	O
LEPOC\|Ensembl=ENSLOCG00000007589.1\|UniProtKB=W5MLE9	lepisosteus oculatus	O
LEPOC\|Ensembl=ENSLOCG00000007609.1\|UniProtKB=W5MLI1	lepisosteus oculatus	O
ORYLA\|Ensembl=ENSORLG00000012352.2\|UniProtKB=H2MAB2	Oryzias latipes	LDO
LEPOC\|Ensembl=ENSLOCG00000007540.1\|UniProtKB=W5MLB6	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000002726.3\|UniProtKB=F6TQ36	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000002747.3\|UniProtKB=F7AGV3	Ciona intestinalis	O
BRAFL\|Gene=LOC118430323\|UniProtKB=A0A9J7MBI6	Branchiostoma floridae	O
STRPU\|EnsemblGenome=GeneID_585663\|UniProtKB=A0A7M7P290	Strongylocentrotus purpuratus	O
ANOGA\|EnsemblGenome=AGAP029047\|UniProtKB=A0A1Y9IGS6	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC003136\|UniProtKB=D6WF18	Tribolium castaneum	O
IXOSC\|EnsemblGenome=ISCW007056\|UniProtKB=B7PTI3	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW007148\|UniProtKB=B7PVI9	Ixodes scapularis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g215748\|UniProtKB=A7SQB2	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g223268\|UniProtKB=A7T766	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g138799\|UniProtKB=A7SZ55	Nematostella vectensis	O