PANTHER Gene Information

Gene Symbol(s):

LRRC8A

Organism:

Canis lupus familiaris

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Gene Name:

Leucine rich repeat containing 8 VRAC subunit A

Gene ID:

ENSCAFG00845025448.1

Protein ID:

A0A8I3PQW0

Persistent Id:

PTN000569805

Alternate Ids:

73967844(GI)	XM_548430(refSeq)
ENSCAFP00845035233(Ensembl_PRO)	A0A8I3PQW0_CANLF(UniProtKB-ID)
A0A8I3PQW0(Synonym)	ENSCAFT00845044958(Ensembl_TRS)
491309(GeneID)	ENSCAFG00845025448(Ensembl)
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PANTHER Classification

PANTHER Family:	LEUCINE-RICH REPEAT-CONTAINING (PTHR45752)
PANTHER Subfamily:	VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8A (PTHR45752:SF23)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:	nucleobase-containing compound transport monoatomic anion transmembrane transport aspartate transmembrane transport import across plasma membrane carbohydrate derivative transport organophosphate ester transport
PANTHER GO-slim Cellular Component:	plasma membrane monoatomic ion channel complex cytoplasm
PANTHER protein class:	scaffold/adaptor protein

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	identical protein binding, cyclic-GMP-AMP transmembrane transporter activity, volume-sensitive anion channel activity
GO BP Complete:	cyclic-GMP-AMP transmembrane import across plasma membrane, chloride transmembrane transport, spermatogenesis, response to osmotic stress, positive regulation of myoblast differentiation, cell volume homeostasis, intracellular glucose homeostasis, monoatomic anion transmembrane transport, pre-B cell differentiation, protein hexamerization, positive regulation of insulin secretion, aspartate transmembrane transport, intracellular signal transduction
GO CC Complete:	cytoplasm, monoatomic ion channel complex, lysosomal membrane, plasma membrane, cell surface

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Miscellaneous transport and binding events, Transport of small molecules

Orthologs

ID	Organism	Type
HUMAN\|HGNC=19027\|UniProtKB=Q8IWT6	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000021443.6\|UniProtKB=H2QY01	Pan troglodytes	LDO
MACMU\|Ensembl=ENSMMUG00000017799.4\|UniProtKB=F7E1A8	Macaca mulatta	LDO
MOUSE\|MGI=MGI=2652847\|UniProtKB=Q80WG5	Mus musculus	LDO
RAT\|RGD=1311690\|UniProtKB=Q4V8I7	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000013030.6\|UniProtKB=Q08E42	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000005664.5\|UniProtKB=A0A4X1TJT1	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000013359.4\|UniProtKB=F7BJ71	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000005863.5\|UniProtKB=M3W4V0	Felis catus	LDO
ORNAN\|Ensembl=ENSOANG00000014621.3\|UniProtKB=F7E9Z4	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010028584.1\|UniProtKB=E1BQK4	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000003742.3\|UniProtKB=H9G7Z5	Anolis carolinensis	LDO
DANRE\|ZFIN=ZDB-GENE-060531-43\|UniProtKB=A2BF98	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-030131-5853\|UniProtKB=Q4V8W3	Danio rerio	LDO
STRPU\|EnsemblGenome=LOC100890667\|UniProtKB=A0A7M7N9H3	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC593857\|UniProtKB=A0A7M7PAW3	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00004929\|UniProtKB=Q22875	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00039104\|UniProtKB=A8XWW4	Caenorhabditis briggsae	O
DROME\|FlyBase=FBgn0038504\|UniProtKB=Q9VEK6	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP004485\|UniProtKB=Q7PHC6	Anopheles gambiae	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_315899\|UniProtKB=E9GB72	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW005645\|UniProtKB=B7PKB9	Ixodes scapularis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g189306\|UniProtKB=A7SFP1	Nematostella vectensis	O
YARLI\|EnsemblGenome=YALI0_B18759g\|UniProtKB=Q6CE40	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_03913\|UniProtKB=G5EB41	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_6G08520\|UniProtKB=Q4WMW1	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU08377\|UniProtKB=Q01631	Neurospora crassa	O
SCLS1\|Gene_ORFName=SS1G_07715\|UniProtKB=A7EQW2	Sclerotinia sclerotiorum	O
SCHPO\|PomBase=SPBC19C7.03\|UniProtKB=P14605	Schizosaccharomyces pombe	O
CRYNJ\|EnsemblGenome=CNG03670\|UniProtKB=Q5KDK1	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_05232\|UniProtKB=P49606	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_02676\|UniProtKB=E3JW10	Puccinia graminis	O
PUCGT\|EnsemblGenome=PGTG_13640\|UniProtKB=E3KT26	Puccinia graminis	O
PUCGT\|EnsemblGenome=PGTG_18866\|UniProtKB=E3L900	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_21322\|UniProtKB=F4NSG9	Batrachochytrium dendrobatidis	O
ENTH1\|EnsemblGenome=EHI_081720\|UniProtKB=C4M699	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_087420\|UniProtKB=C4LXT5	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_024640\|UniProtKB=C4M0K6	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0294094\|UniProtKB=Q54AX5	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_36946\|UniProtKB=F0ZRY2	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_160203\|UniProtKB=F1A5X2	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_34_0640\|UniProtKB=Q4Q3E3	Leishmania major	O
TRIV3\|Gene_ORFName=TVAG_093970\|UniProtKB=A2DBL9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_093780\|UniProtKB=A2DBK1	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_201970\|UniProtKB=A2DWL8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_442260\|UniProtKB=A2F1W9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_028660\|UniProtKB=A2E0B3	Trichomonas vaginalis	O
PARTE\|EnsemblGenome=GSPATT00037265001\|UniProtKB=A0CCG3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00015320001\|UniProtKB=A0DBK7	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPSDRAFT_1268\|UniProtKB=B8BQF6	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_7450\|UniProtKB=B8C6J7	Thalassiosira pseudonana	O
PHYRM\|Gene=H3H5A3_PHYRM\|UniProtKB=H3H5A3	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_02g115508v5\|UniProtKB=A0A2K3E396	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_10g466150v5\|UniProtKB=A0A2K3DCA3	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_06g248900v5\|UniProtKB=A0A2K3DLT6	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_02g107700v5\|UniProtKB=A0A2K3E2R0	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_03g205697v5\|UniProtKB=A0A2K3DZT4	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_06g311750v5\|UniProtKB=A0A2K3DRQ9	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_02g093850v5\|UniProtKB=A0A2K3E1G8	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_16g685600v5\|UniProtKB=A0A2K3CUR7	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_17g697000v5\|UniProtKB=A0A2K3CNM6	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_16g684800v5\|UniProtKB=A0A2K3CUT1	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00110p00083560\|UniProtKB=W1NYZ9	Amborella trichopoda	O
MUSAM\|EnsemblGenome=Ma05_g07170\|UniProtKB=A0A804J1V4	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_036233mg\|UniProtKB=K4ABH6	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3001G231500\|UniProtKB=C5WZI5	Sorghum bicolor	O
ORYSJ\|Gene_OrderedLocusName=LOC_Os10g31790\|UniProtKB=Q7XDQ7	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_3g27860v3\|UniProtKB=I1I4E3	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.1HG0039370\|UniProtKB=F2DS26	Hordeum vulgare subsp. vulgare	O
NELNU\|Gene=LOC104597302\|UniProtKB=A0A1U8A5I9	Nelumbo nucifera	O
HELAN\|EnsemblGenome=HanXRQr2_Chr07g0287421\|UniProtKB=A0A251ULE9	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C800434480\|UniProtKB=A0A9R1UTX5	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a010971mg\|UniProtKB=A0A022S0Y7	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_16035\|UniProtKB=A0A2G2Z7J9	Capsicum annuum	O
CAPAN\|EnsemblGenome=T459_16043\|UniProtKB=A0A2G2Z7W0	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400020546\|UniProtKB=M1BU62	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc06g007250.3\|UniProtKB=A0A3Q7GQS4	Solanum lycopersicum	O
TOBAC\|Gene=LOC107829767\|UniProtKB=A0A1S4DH76	Nicotiana tabacum	O
TOBAC\|Gene=LOC107793856\|UniProtKB=A0A1S4A542	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi06g00691\|UniProtKB=D7SJT3	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_B02227\|UniProtKB=A0A059D5C7	Eucalyptus grandis	O
BRANA\|Gene_ORFName=DARMORV10_A04P22790.1\|UniProtKB=A0A078GYN4	Brassica napus	O
BRACM\|EnsemblGenome=Bra021606\|UniProtKB=M4DYL0	Brassica campestris	O
ARATH\|TAIR=locus=6530298186\|UniProtKB=P0C895	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107927102\|UniProtKB=A0A1U8LG10	Gossypium hirsutum	O
GOSHI\|Gene=LOC107887517\|UniProtKB=A0A1U8HMJ7	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_042197\|UniProtKB=A0A061GYH6	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g017986mg\|UniProtKB=A0A067FU48	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_001G280500v3\|UniProtKB=B9GGR4	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_18G144200\|UniProtKB=A0A2C9U535	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_1093190\|UniProtKB=B9SKU7	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_11G166200\|UniProtKB=A0A0R0HI53	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_18G059000\|UniProtKB=K7MQ74	Glycine max	O
MEDTR\|EnsemblGenome=MTR_3g465570\|UniProtKB=A0A072UX66	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr14_08540\|UniProtKB=A0A2I4FA20	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_6G181600\|UniProtKB=A0A0A0KBL0	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_6G052000\|UniProtKB=M5WBC5	Prunus persica	O
ZOSMR\|Gene_ORFName=ZOSMA_19G00560\|UniProtKB=A0A0K9PNC6	Zostera marina	O
SETIT\|EnsemblGenome=SETIT_009199mg\|UniProtKB=K3Y4R1	Setaria italica	O
SETIT\|EnsemblGenome=SETIT_012295mg\|UniProtKB=K3YDJ0	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3007G071950\|UniProtKB=A0A1Z5R9D1	Sorghum bicolor	O
SETIT\|EnsemblGenome=SETIT_037087mg\|UniProtKB=K4ADY0	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3001G459500\|UniProtKB=C5WTM6	Sorghum bicolor	O
ORYSJ\|EnsemblGenome=Os03g0212200\|UniProtKB=B9F655	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_1g70250v3\|UniProtKB=A0A0Q3HJ89	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.4HG0397280\|UniProtKB=F2DGA5	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS4A02G055400\|UniProtKB=A0A3B6HNG8	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1A02G350800\|UniProtKB=A0A3B5Y4Q4	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS4B02G249200\|UniProtKB=A0A3B6IVK6	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1B02G365000\|UniProtKB=A0A3B5Z280	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1D02G353700\|UniProtKB=A0A3B5ZZS2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS4D02G249500\|UniProtKB=A0A3B6JKA7	Triticum aestivum	O
NELNU\|Gene=LOC104597983\|UniProtKB=A0A1U8A985	Nelumbo nucifera	O
SPIOL\|Gene=LOC110789868\|UniProtKB=A0A9R0IJ45	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr02g0061941\|UniProtKB=A0A251VEV4	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C100006320\|UniProtKB=A0A9R1WJ53	Lactuca sativa	O
HELAN\|EnsemblGenome=HanXRQr2_Chr01g0006121\|UniProtKB=A0A251VKC4	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr09g0408441\|UniProtKB=A0A251SG90	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C400200690\|UniProtKB=A0A9R1VWE9	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a012122mg\|UniProtKB=A0A022PSK7	Erythranthe guttata	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a018225mg\|UniProtKB=A0A022QM55	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_10374\|UniProtKB=A0A1U8FVZ3	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG401024548\|UniProtKB=M1CA27	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc03g115410.3\|UniProtKB=A0A3Q7FS08	Solanum lycopersicum	O
TOBAC\|Gene=LOC107808836\|UniProtKB=A0A1S4BJ26	Nicotiana tabacum	O
TOBAC\|Gene=LOC107806366\|UniProtKB=A0A1S4BB02	Nicotiana tabacum	O
CAPAN\|EnsemblGenome=T459_23713\|UniProtKB=A0A2G2YT36	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400005395\|UniProtKB=M1A3C3	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc12g040320.2\|UniProtKB=A0A3Q7J8T8	Solanum lycopersicum	O
TOBAC\|Gene=LOC107781648\|UniProtKB=A0A1S3Z0F9	Nicotiana tabacum	O
TOBAC\|Gene=LOC107815989\|UniProtKB=A0A1S4C7L3	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi18g02375\|UniProtKB=F6GW07	Vitis vinifera	O
VITVI\|EnsemblGenome=Vitvi17g00680\|UniProtKB=D7SI42	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_K02503\|UniProtKB=A0A059A5D2	Eucalyptus grandis	O
BRANA\|Gene_ORFName=DARMORV10_C02P03310.1\|UniProtKB=A0A078FMD9	Brassica napus	O
BRANA\|Gene_ORFName=GSBRNA2T00071671001\|UniProtKB=A0A078HQ96	Brassica napus	O
BRACM\|EnsemblGenome=Bra005960\|UniProtKB=M4CP22	Brassica campestris	O
BRACM\|EnsemblGenome=Bra028680\|UniProtKB=M4EIR5	Brassica campestris	O
ARATH\|TAIR=locus=2142773\|UniProtKB=Q8RWI2	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107951243\|UniProtKB=A0A1U8NUN9	Gossypium hirsutum	O
GOSHI\|Gene=LOC107931496\|UniProtKB=A0A1U8M034	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_014164\|UniProtKB=A0A061FWT2	Theobroma cacao	O
POPTR\|EnsemblGenome=POPTR_015G048800v3\|UniProtKB=B9IE13	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_06G087000\|UniProtKB=A0A2C9VP61	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_1470450\|UniProtKB=B9RLR8	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_04G164100\|UniProtKB=I1JWQ3	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_06G201600\|UniProtKB=I1KCZ0	Glycine max	O
JUGRE\|EnsemblGenome=Jr02_06530\|UniProtKB=A0A2I4EML2	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_1G012140\|UniProtKB=A0A0A0LPH7	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_5G201600\|UniProtKB=A0A251PB47	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_83151\|UniProtKB=D8R217	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_420321\|UniProtKB=D8SBM1	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_438024\|UniProtKB=D8QST9	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c6_19101\|UniProtKB=A0A2K1KG99	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c15_14980\|UniProtKB=A0A2K1JD88	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c19_5770\|UniProtKB=A9TS86	Physcomitrella patens	O
KLENI\|Gene_ORFName=KFL_001760070\|UniProtKB=A0A1Y1I7L7	Klebsormidium nitens	O