PANTHER Gene Information

Gene Symbol(s):

LRRC8A

Organism:

Equus caballus

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Tree

Gene Name:

Leucine rich repeat containing 8 VRAC subunit A

Gene ID:

ENSECAG00000013359.4

Protein ID:

F7BJ71

Persistent Id:

PTN001504089

Alternate Ids:

149737992(GI)	XP_005605910(refSeq)
F7BJ71_HORSE(UniProtKB-ID)	F7BJ71(Synonym)
ENSECAP00000011134(Ensembl_PRO)	ENSECAT00000013977(Ensembl_TRS)
ENSECAG00000013359(Ensembl)	100066843(GeneID)
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PANTHER Classification

PANTHER Family:	LEUCINE-RICH REPEAT-CONTAINING (PTHR45752)
PANTHER Subfamily:	VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8A (PTHR45752:SF23)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:	nucleobase-containing compound transport monoatomic anion transmembrane transport aspartate transmembrane transport import across plasma membrane carbohydrate derivative transport organophosphate ester transport
PANTHER GO-slim Cellular Component:	plasma membrane monoatomic ion channel complex cytoplasm
PANTHER protein class:	scaffold/adaptor protein

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	identical protein binding, cyclic-GMP-AMP transmembrane transporter activity, monoatomic anion channel activity, volume-sensitive anion channel activity
GO BP Complete:	transmembrane transport, cyclic-GMP-AMP transmembrane import across plasma membrane, chloride transmembrane transport, spermatogenesis, monoatomic ion transmembrane transport, response to osmotic stress, positive regulation of myoblast differentiation, monoatomic anion transport, cell volume homeostasis, intracellular glucose homeostasis, monoatomic anion transmembrane transport, pre-B cell differentiation, protein hexamerization, positive regulation of insulin secretion, aspartate transmembrane transport, intracellular signal transduction
GO CC Complete:	cytoplasm, membrane, monoatomic ion channel complex, lysosomal membrane, plasma membrane, cell surface

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=19027\|UniProtKB=Q8IWT6	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000021443.6\|UniProtKB=H2QY01	Pan troglodytes	LDO
MACMU\|Ensembl=ENSMMUG00000017799.4\|UniProtKB=F7E1A8	Macaca mulatta	LDO
MOUSE\|MGI=MGI=2652847\|UniProtKB=Q80WG5	Mus musculus	LDO
RAT\|RGD=1311690\|UniProtKB=Q4V8I7	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000013030.6\|UniProtKB=Q08E42	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000005664.5\|UniProtKB=A0A4X1TJT1	Sus scrofa	LDO
FELCA\|Ensembl=ENSFCAG00000005863.5\|UniProtKB=M3W4V0	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845025448.1\|UniProtKB=A0A8I3PQW0	Canis lupus familiaris	LDO
ORNAN\|Ensembl=ENSOANG00000014621.3\|UniProtKB=F7E9Z4	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010028584.1\|UniProtKB=E1BQK4	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000003742.3\|UniProtKB=H9G7Z5	Anolis carolinensis	LDO
DANRE\|ZFIN=ZDB-GENE-060531-43\|UniProtKB=A2BF98	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-030131-5853\|UniProtKB=Q4V8W3	Danio rerio	LDO
STRPU\|EnsemblGenome=LOC100890667\|UniProtKB=A0A7M7N9H3	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC593857\|UniProtKB=A0A7M7PAW3	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00004929\|UniProtKB=Q22875	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00039104\|UniProtKB=A8XWW4	Caenorhabditis briggsae	O
DROME\|FlyBase=FBgn0038504\|UniProtKB=Q9VEK6	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP004485\|UniProtKB=Q7PHC6	Anopheles gambiae	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_315899\|UniProtKB=E9GB72	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW005645\|UniProtKB=B7PKB9	Ixodes scapularis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g189306\|UniProtKB=A7SFP1	Nematostella vectensis	O
YARLI\|EnsemblGenome=YALI0_B18759g\|UniProtKB=Q6CE40	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_03913\|UniProtKB=G5EB41	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_6G08520\|UniProtKB=Q4WMW1	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU08377\|UniProtKB=Q01631	Neurospora crassa	O
SCLS1\|Gene_ORFName=SS1G_07715\|UniProtKB=A7EQW2	Sclerotinia sclerotiorum	O
SCHPO\|PomBase=SPBC19C7.03\|UniProtKB=P14605	Schizosaccharomyces pombe	O
CRYNJ\|EnsemblGenome=CNG03670\|UniProtKB=Q5KDK1	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_05232\|UniProtKB=P49606	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_02676\|UniProtKB=E3JW10	Puccinia graminis	O
PUCGT\|EnsemblGenome=PGTG_13640\|UniProtKB=E3KT26	Puccinia graminis	O
PUCGT\|EnsemblGenome=PGTG_18866\|UniProtKB=E3L900	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_21322\|UniProtKB=F4NSG9	Batrachochytrium dendrobatidis	O
ENTH1\|EnsemblGenome=EHI_081720\|UniProtKB=C4M699	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_087420\|UniProtKB=C4LXT5	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_024640\|UniProtKB=C4M0K6	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0294094\|UniProtKB=Q54AX5	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_36946\|UniProtKB=F0ZRY2	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_160203\|UniProtKB=F1A5X2	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_34_0640\|UniProtKB=Q4Q3E3	Leishmania major	O
TRIV3\|Gene_ORFName=TVAG_093970\|UniProtKB=A2DBL9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_093780\|UniProtKB=A2DBK1	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_201970\|UniProtKB=A2DWL8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_442260\|UniProtKB=A2F1W9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_028660\|UniProtKB=A2E0B3	Trichomonas vaginalis	O
PARTE\|EnsemblGenome=GSPATT00037265001\|UniProtKB=A0CCG3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00015320001\|UniProtKB=A0DBK7	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPSDRAFT_1268\|UniProtKB=B8BQF6	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_7450\|UniProtKB=B8C6J7	Thalassiosira pseudonana	O
PHYRM\|Gene=H3H5A3_PHYRM\|UniProtKB=H3H5A3	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_02g115508v5\|UniProtKB=A0A2K3E396	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_10g466150v5\|UniProtKB=A0A2K3DCA3	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_06g248900v5\|UniProtKB=A0A2K3DLT6	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_02g107700v5\|UniProtKB=A0A2K3E2R0	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_03g205697v5\|UniProtKB=A0A2K3DZT4	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_06g311750v5\|UniProtKB=A0A2K3DRQ9	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_02g093850v5\|UniProtKB=A0A2K3E1G8	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_16g685600v5\|UniProtKB=A0A2K3CUR7	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_17g697000v5\|UniProtKB=A0A2K3CNM6	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_16g684800v5\|UniProtKB=A0A2K3CUT1	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00110p00083560\|UniProtKB=W1NYZ9	Amborella trichopoda	O
MUSAM\|EnsemblGenome=Ma05_g07170\|UniProtKB=A0A804J1V4	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_036233mg\|UniProtKB=K4ABH6	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3001G231500\|UniProtKB=C5WZI5	Sorghum bicolor	O
ORYSJ\|Gene_OrderedLocusName=LOC_Os10g31790\|UniProtKB=Q7XDQ7	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_3g27860v3\|UniProtKB=I1I4E3	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.1HG0039370\|UniProtKB=F2DS26	Hordeum vulgare subsp. vulgare	O
NELNU\|Gene=LOC104597302\|UniProtKB=A0A1U8A5I9	Nelumbo nucifera	O
HELAN\|EnsemblGenome=HanXRQr2_Chr07g0287421\|UniProtKB=A0A251ULE9	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C800434480\|UniProtKB=A0A9R1UTX5	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a010971mg\|UniProtKB=A0A022S0Y7	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_16035\|UniProtKB=A0A2G2Z7J9	Capsicum annuum	O
CAPAN\|EnsemblGenome=T459_16043\|UniProtKB=A0A2G2Z7W0	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400020546\|UniProtKB=M1BU62	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc06g007250.3\|UniProtKB=A0A3Q7GQS4	Solanum lycopersicum	O
TOBAC\|Gene=LOC107829767\|UniProtKB=A0A1S4DH76	Nicotiana tabacum	O
TOBAC\|Gene=LOC107793856\|UniProtKB=A0A1S4A542	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi06g00691\|UniProtKB=D7SJT3	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_B02227\|UniProtKB=A0A059D5C7	Eucalyptus grandis	O
BRANA\|Gene_ORFName=DARMORV10_A04P22790.1\|UniProtKB=A0A078GYN4	Brassica napus	O
BRACM\|EnsemblGenome=Bra021606\|UniProtKB=M4DYL0	Brassica campestris	O
ARATH\|TAIR=locus=6530298186\|UniProtKB=P0C895	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107927102\|UniProtKB=A0A1U8LG10	Gossypium hirsutum	O
GOSHI\|Gene=LOC107887517\|UniProtKB=A0A1U8HMJ7	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_042197\|UniProtKB=A0A061GYH6	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g017986mg\|UniProtKB=A0A067FU48	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_001G280500v3\|UniProtKB=B9GGR4	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_18G144200\|UniProtKB=A0A2C9U535	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_1093190\|UniProtKB=B9SKU7	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_11G166200\|UniProtKB=A0A0R0HI53	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_18G059000\|UniProtKB=K7MQ74	Glycine max	O
MEDTR\|EnsemblGenome=MTR_3g465570\|UniProtKB=A0A072UX66	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr14_08540\|UniProtKB=A0A2I4FA20	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_6G181600\|UniProtKB=A0A0A0KBL0	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_6G052000\|UniProtKB=M5WBC5	Prunus persica	O
ZOSMR\|Gene_ORFName=ZOSMA_19G00560\|UniProtKB=A0A0K9PNC6	Zostera marina	O
SETIT\|EnsemblGenome=SETIT_009199mg\|UniProtKB=K3Y4R1	Setaria italica	O
SETIT\|EnsemblGenome=SETIT_012295mg\|UniProtKB=K3YDJ0	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3007G071950\|UniProtKB=A0A1Z5R9D1	Sorghum bicolor	O
SETIT\|EnsemblGenome=SETIT_037087mg\|UniProtKB=K4ADY0	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3001G459500\|UniProtKB=C5WTM6	Sorghum bicolor	O
ORYSJ\|EnsemblGenome=Os03g0212200\|UniProtKB=B9F655	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_1g70250v3\|UniProtKB=A0A0Q3HJ89	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.4HG0397280\|UniProtKB=F2DGA5	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS4A02G055400\|UniProtKB=A0A3B6HNG8	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1A02G350800\|UniProtKB=A0A3B5Y4Q4	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS4B02G249200\|UniProtKB=A0A3B6IVK6	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1B02G365000\|UniProtKB=A0A3B5Z280	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1D02G353700\|UniProtKB=A0A3B5ZZS2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS4D02G249500\|UniProtKB=A0A3B6JKA7	Triticum aestivum	O
NELNU\|Gene=LOC104597983\|UniProtKB=A0A1U8A985	Nelumbo nucifera	O
SPIOL\|Gene=LOC110789868\|UniProtKB=A0A9R0IJ45	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr02g0061941\|UniProtKB=A0A251VEV4	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C100006320\|UniProtKB=A0A9R1WJ53	Lactuca sativa	O
HELAN\|EnsemblGenome=HanXRQr2_Chr01g0006121\|UniProtKB=A0A251VKC4	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr09g0408441\|UniProtKB=A0A251SG90	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C400200690\|UniProtKB=A0A9R1VWE9	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a012122mg\|UniProtKB=A0A022PSK7	Erythranthe guttata	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a018225mg\|UniProtKB=A0A022QM55	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_10374\|UniProtKB=A0A1U8FVZ3	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG401024548\|UniProtKB=M1CA27	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc03g115410.3\|UniProtKB=A0A3Q7FS08	Solanum lycopersicum	O
TOBAC\|Gene=LOC107808836\|UniProtKB=A0A1S4BJ26	Nicotiana tabacum	O
TOBAC\|Gene=LOC107806366\|UniProtKB=A0A1S4BB02	Nicotiana tabacum	O
CAPAN\|EnsemblGenome=T459_23713\|UniProtKB=A0A2G2YT36	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400005395\|UniProtKB=M1A3C3	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc12g040320.2\|UniProtKB=A0A3Q7J8T8	Solanum lycopersicum	O
TOBAC\|Gene=LOC107781648\|UniProtKB=A0A1S3Z0F9	Nicotiana tabacum	O
TOBAC\|Gene=LOC107815989\|UniProtKB=A0A1S4C7L3	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi18g02375\|UniProtKB=F6GW07	Vitis vinifera	O
VITVI\|EnsemblGenome=Vitvi17g00680\|UniProtKB=D7SI42	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_K02503\|UniProtKB=A0A059A5D2	Eucalyptus grandis	O
BRANA\|Gene_ORFName=DARMORV10_C02P03310.1\|UniProtKB=A0A078FMD9	Brassica napus	O
BRANA\|Gene_ORFName=GSBRNA2T00071671001\|UniProtKB=A0A078HQ96	Brassica napus	O
BRACM\|EnsemblGenome=Bra005960\|UniProtKB=M4CP22	Brassica campestris	O
BRACM\|EnsemblGenome=Bra028680\|UniProtKB=M4EIR5	Brassica campestris	O
ARATH\|TAIR=locus=2142773\|UniProtKB=Q8RWI2	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107951243\|UniProtKB=A0A1U8NUN9	Gossypium hirsutum	O
GOSHI\|Gene=LOC107931496\|UniProtKB=A0A1U8M034	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_014164\|UniProtKB=A0A061FWT2	Theobroma cacao	O
POPTR\|EnsemblGenome=POPTR_015G048800v3\|UniProtKB=B9IE13	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_06G087000\|UniProtKB=A0A2C9VP61	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_1470450\|UniProtKB=B9RLR8	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_04G164100\|UniProtKB=I1JWQ3	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_06G201600\|UniProtKB=I1KCZ0	Glycine max	O
JUGRE\|EnsemblGenome=Jr02_06530\|UniProtKB=A0A2I4EML2	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_1G012140\|UniProtKB=A0A0A0LPH7	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_5G201600\|UniProtKB=A0A251PB47	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_83151\|UniProtKB=D8R217	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_420321\|UniProtKB=D8SBM1	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_438024\|UniProtKB=D8QST9	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c6_19101\|UniProtKB=A0A2K1KG99	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c15_14980\|UniProtKB=A0A2K1JD88	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c19_5770\|UniProtKB=A9TS86	Physcomitrella patens	O
KLENI\|Gene_ORFName=KFL_001760070\|UniProtKB=A0A1Y1I7L7	Klebsormidium nitens	O