PANTHER Gene Information   
Gene Symbol(s): NF2
Organism: Canis lupus familiaris
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Gene Name: NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor
Gene ID: ENSCAFG00845030750.1
Protein ID: A0A8I3QBP5
Persistent Id: PTN000590113
Alternate Ids:
A0A8I3QBP5(Synonym) ENSCAFT00845054664(Ensembl_TRS)
73994973(GI) ENSCAFG00845030750(Ensembl)
A0A8I3QBP5_CANLF(UniProtKB-ID) XM_534729(refSeq)
ENSCAFP00845042987(Ensembl_PRO) 477535(GeneID)
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PANTHER Classification
PANTHER Family: MERLIN/MOESIN/EZRIN/RADIXIN (PTHR23281)
PANTHER Subfamily: MERLIN (PTHR23281:SF42)  
PANTHER GO-slim Molecular Function: actin binding
integrin binding
PANTHER GO-slim Biological Process: regulation of vesicle-mediated transport
regulation of intracellular signal transduction
negative regulation of cell population proliferation
regulation of organelle assembly
regulation of neurogenesis
regulation of cell shape
positive regulation of transport
positive regulation of protein localization
PANTHER GO-slim Cellular Component: plasma membrane
apical part of cell
adherens junction
filopodium
PANTHER protein class: actin or actin-binding cytoskeletal protein
Pathway Categories: No pathway information available
GO MF Complete: actin binding, integrin binding
GO BP Complete: regulation of cell shape, negative regulation of MAPK cascade, negative regulation of cell population proliferation, negative regulation of cell-cell adhesion, regulation of stem cell proliferation, odontogenesis of dentin-containing tooth, ectoderm development, regulation of organelle assembly, MAPK cascade, regulation of neural precursor cell proliferation, mesoderm formation, regulation of cell cycle, lens fiber cell differentiation, regulation of hippo signaling, regulation of gliogenesis, Schwann cell proliferation, hippocampus development, regulation of apoptotic process, positive regulation of cell differentiation, cell-cell junction organization, negative regulation of receptor signaling pathway via JAK-STAT, positive regulation of protein localization to early endosome, regulation of protein stability, negative regulation of Schwann cell proliferation, positive regulation of stress fiber assembly, osteoblast proliferation, positive regulation of early endosome to late endosome transport, actin cytoskeleton organization, negative regulation of osteoblast proliferation, regulation of protein localization to nucleus
GO CC Complete: cleavage furrow, nucleolus, neuron projection, plasma membrane, early endosome, adherens junction, perinuclear region of cytoplasm, apical part of cell, microvillus, cell body, ruffle, cytosol, filopodium, cortical actin cytoskeleton, lamellipodium
Reactome Pathways: Signal Transduction, Innate Immune System, Signaling by Rho GTPases, RHO GTPases activate PAKs, Immune System, RHO GTPase Effectors, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Regulation of actin dynamics for phagocytic cup formation, Fcgamma receptor (FCGR) dependent phagocytosis