PANTHER Gene Information

Gene Symbol(s):

nf2

Organism:

Xenopus tropicalis

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Gene Name:

Merlin isoform X1

Gene ID:

XB-GENE-984959

Protein ID:

F7AZR8

Persistent Id:

PTN008596474

Alternate Ids:

ENSXETP00000053343(Ensembl_PRO)	XP_012820654(refSeq)
ENSXETT00000053343(Ensembl_TRS)	779815(GeneID)
ENSXETG00000016421(Ensembl)	F7AZR8(Synonym)
847088542(GI)	F7AZR8_XENTR(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	MERLIN/MOESIN/EZRIN/RADIXIN (PTHR23281)
PANTHER Subfamily:	NEUROFIBROMIN 2 (PTHR23281:SF23)
PANTHER GO-slim Molecular Function:	actin binding integrin binding
PANTHER GO-slim Biological Process:	regulation of vesicle-mediated transport regulation of intracellular signal transduction negative regulation of cell population proliferation regulation of organelle assembly regulation of neurogenesis regulation of cell shape positive regulation of transport positive regulation of protein localization
PANTHER GO-slim Cellular Component:	plasma membrane apical part of cell adherens junction filopodium
PANTHER protein class:	actin or actin-binding cytoskeletal protein

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	actin binding, integrin binding
GO BP Complete:	regulation of cell shape, regulation of hippo signaling, regulation of gliogenesis, negative regulation of cell population proliferation, positive regulation of early endosome to late endosome transport, regulation of organelle assembly, positive regulation of protein localization to early endosome
GO CC Complete:	adherens junction, cytoskeleton, apical part of cell, filopodium, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Signal Transduction, Fcgamma receptor (FCGR) dependent phagocytosis, Innate Immune System, Signaling by Rho GTPases, Regulation of actin dynamics for phagocytic cup formation, Immune System, RHO GTPases activate PAKs, RHO GTPase Effectors, Signaling by Rho GTPases, Miro GTPases and RHOBTB3

Orthologs

ID	Organism	Type
HUMAN\|HGNC=7773\|UniProtKB=P35240	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000014227.7\|UniProtKB=K7DSQ5	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000003781.3\|UniProtKB=A0A2I2ZFQ4	Gorilla gorilla gorilla	O
MOUSE\|MGI=MGI=97307\|UniProtKB=P46662	Mus musculus	O
PIG\|Ensembl=ENSSSCG00000028707.4\|UniProtKB=A0A480KT19	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000022976.4\|UniProtKB=A0A5F5Q456	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000004249.6\|UniProtKB=M3W1U9	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845030750.1\|UniProtKB=A0A8I3QBP5	Canis lupus familiaris	O
GORGO\|Ensembl=ENSGGOG00000003781.3\|UniProtKB=A0A2I2ZFQ4	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000010311.4\|UniProtKB=F6RPZ9	Macaca mulatta	LDO
RAT\|RGD=3169\|UniProtKB=Q63648	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000013153.5\|UniProtKB=A0A3Q1M7A4	Bos taurus	LDO
MONDO\|Ensembl=ENSMODG00000008904.4\|UniProtKB=F7GLA2	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000012780.3\|UniProtKB=F7A6R8	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010000153.1\|UniProtKB=A0A8V0WZJ7	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000008829.3\|UniProtKB=A0A803T2Y7	Anolis carolinensis	LDO
XENLA\|Gene=nf2.L\|UniProtKB=A0A8J0VAP2	Xenopus laevis	LDO
XENLA\|Gene=nf2.S\|UniProtKB=A0A8J0TZA3	Xenopus laevis	LDO
ORYLA\|Ensembl=ENSORLG00000000897.2\|UniProtKB=A0A3B3HZJ5	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-080722-7\|UniProtKB=B3DGL5	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000003628.1\|UniProtKB=W5M7H1	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000006067.3\|UniProtKB=F6ZG18	Ciona intestinalis	O
STRPU\|EnsemblGenome=LOC575663\|UniProtKB=A0A7M7T1X5	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00003593\|UniProtKB=H2KYX3	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG21105\|UniProtKB=A8XZG8	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00092111\|UniProtKB=A0A2A6BQ23	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0086384\|UniProtKB=Q24564	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP010346\|UniProtKB=A0A1S4H4J1	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC014860\|UniProtKB=D2A4B9	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_128926\|UniProtKB=E9GW23	Daphnia pulex	O
HELRO\|EnsemblGenome=HelroG189253\|UniProtKB=T1FQV5	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g234576\|UniProtKB=A7RWH0	Nematostella vectensis	O
MONBE\|EnsemblGenome=MONBRDRAFT_36461\|UniProtKB=A9UUN2	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_14158\|UniProtKB=A9UPA6	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_32815\|UniProtKB=A9V1V5	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_17480\|UniProtKB=A9URX5	Monosiga brevicollis	O