PANTHER Gene Information

Gene Symbol(s):

TEK

Organism:

Gallus gallus

View Gene in Tree


Tree	Reduced Tree

Gene Name:

receptor protein-tyrosine kinase

Gene ID:

ENSGALG00010006538.1

Protein ID:

A0A3Q2UKD3

Persistent Id:

PTN000698977

Alternate Ids:

427368(GeneID)	A0A3Q2UKD3_CHICK(UniProtKB-ID)
A0A3Q2UKD3(Synonym)	ENSGALP00010009064(Ensembl_PRO)
ENSGALG00010006538(Ensembl)	XP_004949637(refSeq)
ENSGALT00010015548(Ensembl_TRS)	513232667(GI)
Show All

PANTHER Classification

PANTHER Family:	TYROSINE-PROTEIN KINASE RECEPTOR (PTHR24416)
PANTHER Subfamily:	ANGIOPOIETIN-1 RECEPTOR (PTHR24416:SF125)
PANTHER GO-slim Molecular Function:	transmembrane receptor protein tyrosine kinase activity
PANTHER GO-slim Biological Process:	angiogenesis regulation of angiogenesis endothelial cell proliferation positive regulation of cell migration positive regulation of multicellular organismal process positive regulation of kinase activity positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of developmental process positive regulation of MAPK cascade
PANTHER GO-slim Cellular Component:	plasma membrane receptor complex
PANTHER protein class:	transmembrane signal receptor

Pathway Categories:

Angiogenesis

Tie-2

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	placental growth factor receptor activity, identical protein binding, stem cell factor receptor activity, brain-derived neurotrophic factor receptor activity, macrophage colony-stimulating factor receptor activity, protein tyrosine kinase collagen receptor activity, insulin-like growth factor receptor activity, vascular endothelial growth factor receptor activity, boss receptor activity, GPI-linked ephrin receptor activity, epidermal growth factor receptor activity, transmembrane-ephrin receptor activity, hepatocyte growth factor receptor activity, platelet-derived growth factor beta-receptor activity, fibroblast growth factor receptor activity, platelet-derived growth factor alpha-receptor activity, ATP binding, insulin receptor activity, transmembrane receptor protein tyrosine kinase activity, metal ion binding
GO BP Complete:	positive regulation of Rac protein signal transduction, negative regulation of angiogenesis, positive regulation of Rho protein signal transduction, multicellular organism development, insulin receptor signaling pathway, epidermal growth factor receptor signaling pathway, sprouting angiogenesis, fibroblast growth factor receptor signaling pathway, positive regulation of angiogenesis, angiogenesis, substrate adhesion-dependent cell spreading, positive regulation of endothelial cell migration, Kit signaling pathway, vascular endothelial growth factor receptor-1 signaling pathway, platelet-derived growth factor receptor-alpha signaling pathway, macrophage colony-stimulating factor signaling pathway, platelet-derived growth factor receptor-beta signaling pathway, vascular endothelial growth factor signaling pathway, insulin-like growth factor receptor signaling pathway, cell surface receptor protein tyrosine kinase signaling pathway, collagen-activated tyrosine kinase receptor signaling pathway, positive regulation of MAPK cascade, hepatocyte growth factor receptor signaling pathway, brain-derived neurotrophic factor receptor signaling pathway, regulation of establishment or maintenance of cell polarity, positive regulation of focal adhesion assembly, Tie signaling pathway, ephrin receptor signaling pathway, positive regulation of ERK1 and ERK2 cascade, endothelial cell proliferation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO CC Complete:	cell-cell junction, microvillus, centriolar satellite, stress fiber, membrane raft, receptor complex, actin filament, basolateral plasma membrane, plasma membrane, apical plasma membrane, cell surface

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

MAPK1/MAPK3 signaling, Hemostasis, Tie2 Signaling, Cell surface interactions at the vascular wall, RAF/MAP kinase cascade, MAPK family signaling cascades, Signal Transduction

Orthologs

ID	Organism	Type
HUMAN\|HGNC=11724\|UniProtKB=Q02763	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000020835.6\|UniProtKB=A0A2I3RZH3	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000015924.3\|UniProtKB=G3RIN5	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000006080.4\|UniProtKB=F6VW12	Macaca mulatta	LDO
MOUSE\|MGI=MGI=98664\|UniProtKB=Q02858	Mus musculus	LDO
RAT\|RGD=620980\|UniProtKB=D3ZCD0	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000020148\|UniProtKB=Q06807	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000005122.6\|UniProtKB=K7GQ34	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000016566.4\|UniProtKB=A0A9L0T8J6	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000002830.6\|UniProtKB=M3VZ78	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845018055.1\|UniProtKB=A0A8I3S0B4	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000004269.4\|UniProtKB=F6TEV1	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000013231.4\|UniProtKB=F6UTL2	Ornithorhynchus anatinus	LDO
ANOCA\|Ensembl=ENSACAG00000017459.4\|UniProtKB=G1KU09	Anolis carolinensis	LDO
XENLA\|Gene=tek.S\|UniProtKB=A0A1L8HP14	Xenopus laevis	O
XENLA\|Gene=tek.L\|UniProtKB=A0A8J0UZW6	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-483684\|UniProtKB=A0A6I8T2P4	Xenopus tropicalis	LDO
DANRE\|Gene=tek\|UniProtKB=A0A8M3ARU2	Danio rerio	LDO
DANRE\|ZFIN=ZDB-GENE-990415-56\|UniProtKB=O73791	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000003173.1\|UniProtKB=W5M5U9	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118432243\|UniProtKB=A0A9J7NDK0	Branchiostoma floridae	O
BRAFL\|Gene=LOC118431533\|UniProtKB=A0A9J7MCD0	Branchiostoma floridae	O
BRAFL\|Gene=LOC118410884\|UniProtKB=A0A9J7MIL3	Branchiostoma floridae	O
BRAFL\|Gene=LOC118431526\|UniProtKB=A0A9J7NCD2	Branchiostoma floridae	O
BRAFL\|Gene=LOC118416664\|UniProtKB=A0A9J7MSZ6	Branchiostoma floridae	O
BRAFL\|Gene=LOC118431263\|UniProtKB=A0A9J7NCM0	Branchiostoma floridae	O
STRPU\|EnsemblGenome=GeneID_592402\|UniProtKB=A0A7M7PIL3	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00020966\|UniProtKB=Q23136	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG05171\|UniProtKB=A8WZA7	Caenorhabditis briggsae	O
DROME\|FlyBase=FBgn0011829\|UniProtKB=Q7KT06	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP008899\|UniProtKB=A0A1S4H0B3	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC012783\|UniProtKB=D6X0D7	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_40778\|UniProtKB=E9FTN9	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW003506\|UniProtKB=B7PIC9	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG133652\|UniProtKB=T1EI21	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g134557\|UniProtKB=A7SVX1	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g210816\|UniProtKB=A7SE14	Nematostella vectensis	O
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g150265\|UniProtKB=A7T8I7	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g1620\|UniProtKB=A7SZN9	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g117565\|UniProtKB=A7SGK0	Nematostella vectensis	O
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g120496\|UniProtKB=A7SJE2	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g41034\|UniProtKB=A7SQ51	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g1840\|UniProtKB=A7T537	Nematostella vectensis	O
MONBE\|EnsemblGenome=MONBRDRAFT_38493\|UniProtKB=A9V865	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_34608\|UniProtKB=A9VCU7	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_27123\|UniProtKB=A9V4D1	Monosiga brevicollis	O