PANTHER Gene Information   
Gene Symbol(s): LRRK2
Organism: Gallus gallus
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Gene Name: non-specific serine_threonine protein kinase
Gene ID: ENSGALG00010009361.1
Protein ID: A0A8V0Y3D1
Persistent Id: PTN001147486
Alternate Ids:
ENSGALT00010022325(Ensembl_TRS) ENSGALG00010009361(Ensembl)
ENSGALP00010012843(Ensembl_PRO) A0A8V0Y3D1(Synonym)
A0A8V0Y3D1_CHICK(UniProtKB-ID)
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PANTHER Classification
PANTHER Family: LEUCINE-RICH REPEAT-CONTAINING (PTHR45752)
PANTHER Subfamily: LEUCINE-RICH REPEAT SERINE_THREONINE-PROTEIN KINASE 2 (PTHR45752:SF7)  
PANTHER GO-slim Molecular Function: MAP kinase kinase kinase activity
PANTHER GO-slim Biological Process: protein phosphorylation
PANTHER GO-slim Cellular Component:
PANTHER protein class: scaffold/adaptor protein
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: tubulin binding, protein homodimerization activity, GTP-dependent protein kinase activity, GTPase activator activity, beta-catenin destruction complex binding, transmembrane transporter binding, magnesium ion binding, GTP binding, ATP binding, actin binding, GTPase activity, JUN kinase kinase kinase activity, syntaxin-1 binding, small GTPase binding, clathrin binding, peroxidase inhibitor activity, signaling receptor complex adaptor activity, protein kinase A binding
GO BP Complete: regulation of kidney size, locomotory exploration behavior, positive regulation of dopamine receptor signaling pathway, determination of adult lifespan, positive regulation of programmed cell death, JNK cascade, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, neuromuscular junction development, calcium-mediated signaling, regulation of synaptic transmission, glutamatergic, intracellular signal transduction, regulation of dendritic spine morphogenesis, regulation of cAMP/PKA signal transduction, excitatory postsynaptic potential, regulation of lysosomal lumen pH, regulation of retrograde transport, endosome to Golgi, regulation of branching morphogenesis of a nerve, positive regulation of canonical Wnt signaling pathway, Rho protein signal transduction, negative regulation of protein targeting to mitochondrion, endocytosis, endoplasmic reticulum organization, regulation of dopamine receptor signaling pathway, regulation of synaptic vesicle transport, positive regulation of autophagy, protein import into nucleus, cellular response to manganese ion, regulation of cell projection organization, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, cellular response to reactive oxygen species, regulation of neuroblast proliferation, regulation of locomotion, Golgi organization, regulation of neuron maturation, regulation of CAMKK-AMPK signaling cascade, tangential migration from the subventricular zone to the olfactory bulb, GTP metabolic process, neuron projection morphogenesis, positive regulation of protein autoubiquitination, negative regulation of excitatory postsynaptic potential, negative regulation of Notch signaling pathway, regulation of ER to Golgi vesicle-mediated transport, negative regulation of protein processing, regulation of canonical Wnt signaling pathway, regulation of reactive oxygen species metabolic process, regulation of mitochondrial depolarization, cellular response to dopamine, regulation of synaptic vesicle endocytosis, Wnt signalosome assembly, cellular response to starvation, negative regulation of autophagosome assembly, mitochondrion organization, regulation of protein stability, intracellular distribution of mitochondria, protein localization to endoplasmic reticulum exit site, regulation of synaptic vesicle exocytosis
GO CC Complete: Wnt signalosome, cytoplasmic side of mitochondrial outer membrane, synaptic vesicle, amphisome, perikaryon, autolysosome, mitochondrial inner membrane, Golgi-associated vesicle, growth cone, caveola neck, trans-Golgi network, multivesicular body, internal vesicle, postsynapse, cytoplasm, mitochondrial matrix, microvillus, presynaptic cytosol, dendrite cytoplasm, endoplasmic reticulum exit site, glutamatergic synapse, ribonucleoprotein complex
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: -

Orthologs