PANTHER Gene Information   
Gene Symbol(s): LRRK2
Organism: Ornithorhynchus anatinus
View Gene in Tree
Tree
Tree
Gene Name: non-specific serine_threonine protein kinase
Gene ID: ENSOANG00000011237.4
Protein ID: F7EB41
Persistent Id: PTN000585177
Alternate Ids:
ENSOANP00000026775(Ensembl_PRO) F7EB41_ORNAN(UniProtKB-ID)
F7EB41(Synonym) ENSOANG00000011237(Ensembl)
ENSOANT00000030575(Ensembl_TRS)
Show All

PANTHER Classification
PANTHER Family: LEUCINE-RICH REPEAT-CONTAINING (PTHR45752)
PANTHER Subfamily: LEUCINE-RICH REPEAT SERINE_THREONINE-PROTEIN KINASE 2 (PTHR45752:SF7)  
PANTHER GO-slim Molecular Function: MAP kinase kinase kinase activity
PANTHER GO-slim Biological Process: protein phosphorylation
PANTHER GO-slim Cellular Component:
PANTHER protein class: scaffold/adaptor protein
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: tubulin binding, GTP-dependent protein kinase activity, GTPase activator activity, beta-catenin destruction complex binding, magnesium ion binding, ribosomal protein S6 kinase activity, GTP binding, DNA-dependent protein kinase activity, ATP binding, histone H2AT120 kinase activity, AMP-activated protein kinase activity, histone H3S57 kinase activity, GTPase activity, histone H4S1 kinase activity, histone H3S28 kinase activity, histone H3T45 kinase activity, histone H2AXS139 kinase activity, identical protein binding, protein homodimerization activity, histone H3S10 kinase activity, histone H2BS14 kinase activity, histone H2AS1 kinase activity, protein kinase activity, eukaryotic translation initiation factor 2alpha kinase activity, SNARE binding, protein serine/threonine kinase activity, transmembrane transporter binding, 3-phosphoinositide-dependent protein kinase activity, histone H2AS121 kinase activity, actin binding, JUN kinase kinase kinase activity, syntaxin-1 binding, histone H3T3 kinase activity, histone H2BS36 kinase activity, small GTPase binding, MAP kinase kinase kinase activity, clathrin binding, Rho-dependent protein serine/threonine kinase activity, kinase activity, peroxidase inhibitor activity, histone H3T11 kinase activity, signaling receptor complex adaptor activity, histone H3T6 kinase activity, protein kinase A binding
GO BP Complete: exploration behavior, regulation of kidney size, locomotory exploration behavior, positive regulation of dopamine receptor signaling pathway, determination of adult lifespan, protein localization, positive regulation of programmed cell death, JNK cascade, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, neuromuscular junction development, positive regulation of protein ubiquitination, calcium-mediated signaling, mitochondrion localization, regulation of synaptic transmission, glutamatergic, intracellular signal transduction, regulation of dendritic spine morphogenesis, regulation of cAMP/PKA signal transduction, excitatory postsynaptic potential, regulation of lysosomal lumen pH, neuron differentiation, regulation of retrograde transport, endosome to Golgi, regulation of branching morphogenesis of a nerve, positive regulation of canonical Wnt signaling pathway, Rho protein signal transduction, negative regulation of protein targeting to mitochondrion, endocytosis, endoplasmic reticulum organization, regulation of signal transduction, regulation of dopamine receptor signaling pathway, regulation of synaptic vesicle transport, positive regulation of autophagy, regulation of membrane potential, protein import into nucleus, regulation of autophagy, cellular response to manganese ion, regulation of gene expression, negative regulation of macroautophagy, regulation of cell projection organization, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, cellular response to reactive oxygen species, regulation of neuroblast proliferation, regulation of locomotion, cell communication, Golgi organization, regulation of neuron maturation, regulation of CAMKK-AMPK signaling cascade, tangential migration from the subventricular zone to the olfactory bulb, GTP metabolic process, neuron projection morphogenesis, positive regulation of protein autoubiquitination, negative regulation of excitatory postsynaptic potential, negative regulation of Notch signaling pathway, olfactory bulb development, MAPK cascade, response to oxidative stress, chromatin remodeling, regulation of ER to Golgi vesicle-mediated transport, negative regulation of protein processing, regulation of canonical Wnt signaling pathway, regulation of reactive oxygen species metabolic process, regulation of mitochondrial depolarization, cellular response to dopamine, lysosome organization, regulation of synaptic vesicle endocytosis, Wnt signalosome assembly, cellular response to starvation, negative regulation of autophagosome assembly, mitochondrion organization, regulation of protein stability, intracellular distribution of mitochondria, protein localization to endoplasmic reticulum exit site, regulation of synaptic vesicle exocytosis, cellular response to oxidative stress
GO CC Complete: Wnt signalosome, cytoplasmic side of mitochondrial outer membrane, synaptic vesicle, Golgi apparatus, amphisome, neuronal cell body, synapse, perikaryon, neuron projection, autolysosome, Golgi-associated vesicle, growth cone, caveola neck, dendrite, trans-Golgi network, multivesicular body, internal vesicle, endosome, postsynapse, microvillus, intracellular membrane-bounded organelle, presynaptic cytosol, cytosol, cytoplasmic vesicle, glutamatergic synapse, ribonucleoprotein complex, axon, endoplasmic reticulum, mitochondrial outer membrane, mitochondrial inner membrane, plasma membrane, lysosome, mitochondrial membrane, cytoplasm, mitochondrial matrix, mitochondrion, dendrite cytoplasm, membrane raft, endoplasmic reticulum exit site
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: -

Orthologs