PANTHER Gene Information

Gene Symbol(s):

slc24a4a

Organism:

Danio rerio

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Gene Name:

Sodium_potassium_calcium exchanger 4 isoform X1

Gene ID:

slc24a4a

Protein ID:

A0A8M2B5T1

Persistent Id:

PTN000851856

Alternate Ids:

XP_005158898(refSeq)	A0A8M2B5T1(Synonym)
A0A8M2B5T1_DANRE(UniProtKB-ID)	550467(GeneID)
528506678(GI)
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PANTHER Classification

PANTHER Family:	SODIUM/POTASSIUM/CALCIUM EXCHANGER (PTHR10846)
PANTHER Subfamily:	SODIUM_POTASSIUM_CALCIUM EXCHANGER 4 (PTHR10846:SF21)
PANTHER GO-slim Molecular Function:	sodium ion transmembrane transporter activity potassium ion transmembrane transporter activity calcium channel activity active monoatomic ion transmembrane transporter activity antiporter activity
PANTHER GO-slim Biological Process:	calcium ion transmembrane transport intracellular calcium ion homeostasis
PANTHER GO-slim Cellular Component:	plasma membrane
PANTHER protein class:	secondary carrier transporter

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	antiporter activity, calcium channel activity, calcium, potassium:sodium antiporter activity
GO BP Complete:	monoatomic ion transport, transmembrane transport, calcium ion transport, calcium ion transmembrane transport, intracellular calcium ion homeostasis
GO CC Complete:	membrane, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=10978\|UniProtKB=Q8NFF2	Homo sapiens	O
GORGO\|Ensembl=ENSGGOG00000008151.3\|UniProtKB=G3QYN1	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000013960.4\|UniProtKB=F6S7H4	Macaca mulatta	O
MOUSE\|MGI=MGI=2447362\|UniProtKB=Q8CGQ8	Mus musculus	O
RAT\|RGD=1305926\|UniProtKB=A0A0G2K3S9	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000006620.6\|UniProtKB=F1MD60	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000002450.5\|UniProtKB=F1SD72	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000013708.4\|UniProtKB=F7BGF8	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000007887.5\|UniProtKB=M3W8K3	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845020809.1\|UniProtKB=A0A8I3PDR2	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000002100.4\|UniProtKB=F7G6D3	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000003823.3\|UniProtKB=F6T5Y9	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010015386.1\|UniProtKB=A0A8V0YS99	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000009184.3\|UniProtKB=A0A803SPZ8	Anolis carolinensis	O
XENLA\|Gene=LOC108698722\|UniProtKB=A0A1L8F9H8	Xenopus laevis	O
XENLA\|Gene=LOC108700484\|UniProtKB=A0A1L8F0F6	Xenopus laevis	O
XENTR\|Gene=slc24a4\|UniProtKB=A0A8J1IRG5	Xenopus tropicalis	O
XENTR\|Xenbase=XB-GENE-478288\|UniProtKB=F6YZS6	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000011649.2\|UniProtKB=H2M7Z7	Oryzias latipes	O
LEPOC\|Ensembl=ENSLOCG00000014107.1\|UniProtKB=W5N9S6	lepisosteus oculatus	O
BRAFL\|Gene=LOC118425860\|UniProtKB=A0A9J7LXC6	Branchiostoma floridae	O
BRAFL\|Gene=LOC118409222\|UniProtKB=A0A9J7KLV7	Branchiostoma floridae	O
BRAFL\|Gene=LOC118423459\|UniProtKB=A0A9J7LR76	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC592113\|UniProtKB=A0A7M7N7L9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC580359\|UniProtKB=A0A7M7NBF4	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115919082\|UniProtKB=A0A7M7PRH3	Strongylocentrotus purpuratus	O
DROME\|FlyBase=FBgn0037238\|UniProtKB=Q9VN12	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP004518\|UniProtKB=Q7PQ73	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC010649\|UniProtKB=A0A139WB83	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_309468\|UniProtKB=E9HCX6	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW010865\|UniProtKB=B7Q4G9	Ixodes scapularis	O
ANOGA\|EnsemblGenome=AGAP010975\|UniProtKB=A7US87	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC013319\|UniProtKB=D6WM88	Tribolium castaneum	O
DROME\|FlyBase=FBgn0039941\|UniProtKB=Q7PLW4	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP010974\|UniProtKB=A0A1S4H695	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP010973\|UniProtKB=A0A1S4H5E6	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC013320\|UniProtKB=D6WM87	Tribolium castaneum	O
DROME\|FlyBase=FBgn0040031\|UniProtKB=A8Y5A2	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0265767\|UniProtKB=Q5LJX8	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP029593\|UniProtKB=A0A453Z087	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC014488\|UniProtKB=D6WM86	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_207878\|UniProtKB=E9G011	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW007235\|UniProtKB=B7PW42	Ixodes scapularis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g85050\|UniProtKB=A7RKL4	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g198469\|UniProtKB=A7RKL3	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g134893\|UniProtKB=A7SW69	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG33154\|UniProtKB=B3SCB1	Trichoplax adhaerens	O
ENTH1\|EnsemblGenome=CL6EHI_018640\|UniProtKB=C4MA70	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=EHI_049410\|UniProtKB=C4LUE3	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_049310\|UniProtKB=C4LUD3	Entamoeba histolytica	O
PARTE\|EnsemblGenome=GSPATT00007604001\|UniProtKB=A0CH97	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00014844001\|UniProtKB=A0DA70	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPSDRAFT_4973\|UniProtKB=B8C1L5	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_10292\|UniProtKB=B8CDR0	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_bd1662\|UniProtKB=B8LEG5	Thalassiosira pseudonana	O
NITMS\|EnsemblGenome=Nmar_0590\|UniProtKB=A9A357	Nitrosopumilus maritimus	O
SACS2\|EnsemblGenome=SSO1174\|UniProtKB=Q97YX8	Sulfolobus solfataricus	O
SACS2\|EnsemblGenome=SSO3192\|UniProtKB=Q97U31	Sulfolobus solfataricus	O
METAC\|EnsemblGenome=MA_2817\|UniProtKB=Q8TM51	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_3021\|UniProtKB=Q8TLL5	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_2008\|UniProtKB=Q8TPA6	Methanosarcina acetivorans	O
METJA\|EnsemblGenome=MJ_0091\|UniProtKB=Q57556	Methanocaldococcus jannaschii	O
HALSA\|EnsemblGenome=VNG_2257G\|UniProtKB=Q9HN44	Halobacterium salinarum	O
HALSA\|EnsemblGenome=VNG_0380G\|UniProtKB=Q9HS69	Halobacterium salinarum	O
THEKO\|EnsemblGenome=TK0867\|UniProtKB=Q5JI20	Thermococcus kodakaraensis	O
CHLAA\|EnsemblGenome=Caur_1857\|UniProtKB=A9WDA7	Chloroflexus aurantiacus	O
CHLAA\|EnsemblGenome=Caur_2211\|UniProtKB=A9WFS0	Chloroflexus aurantiacus	O
THEMA\|EnsemblGenome=TM_0724\|UniProtKB=Q9WZI3	Thermotoga maritima	O
SYNY3\|Gene=P72945_SYNY3\|UniProtKB=P72945	Synechocystis	O
BACTN\|EnsemblGenome=BT_3019\|UniProtKB=Q8A3D5	Bacteroides thetaiotaomicron	O
RHOBA\|EnsemblGenome=RB1641\|UniProtKB=Q7UX07	Rhodopirellula baltica	O
AQUAE\|EnsemblGenome=aq_066\|UniProtKB=O66480	Aquifex aeolicus	O
THEYD\|EnsemblGenome=THEYE_A0130\|UniProtKB=B5YHF9	Thermodesulfovibrio yellowstonii	O
COXBU\|EnsemblGenome=CBU_0095\|UniProtKB=Q83F54	Coxiella burnetii	O
SHEON\|Gene_OrderedLocusName=SO_0354\|UniProtKB=Q8EJV2	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_2522\|UniProtKB=Q9KP54	Vibrio cholerae	O
SALTY\|EnsemblGenome=STM3314\|UniProtKB=Q8ZLS2	Salmonella typhimurium	O
YERPE\|Gene_OrderedLocusName=YPO3576\|UniProtKB=A0A2U2H2F5	Yersinia pestis	O
ECOLI\|EnsemblGenome=BAE77240\|UniProtKB=P45394	Escherichia coli	O