PANTHER Gene Information

Gene Symbol(s):

Organism:

Anopheles gambiae

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Gene Name:

Sodium_calcium exchanger membrane region domain-containing protein

Gene ID:

AGAP010973

Protein ID:

A0A1S4H5E6

Persistent Id:

PTN008507253

Alternate Ids:

AAAB01008823(EMBL)	A0A1S4H5E6_ANOGA(UniProtKB-ID)
AGAP010973-PA(Ensembl_PRO)	AGAP010973(Ensembl)
AGAP010973-RA(Ensembl_TRS)	A0A1S4H5E6(Synonym)
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PANTHER Classification

PANTHER Family:	SODIUM/POTASSIUM/CALCIUM EXCHANGER (PTHR10846)
PANTHER Subfamily:	RE48874P (PTHR10846:SF2)
PANTHER GO-slim Molecular Function:	calcium channel activity active monoatomic ion transmembrane transporter activity sodium ion transmembrane transporter activity antiporter activity potassium ion transmembrane transporter activity
PANTHER GO-slim Biological Process:	calcium ion transmembrane transport intracellular calcium ion homeostasis
PANTHER GO-slim Cellular Component:	plasma membrane
PANTHER protein class:	secondary carrier transporter

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	antiporter activity, calcium channel activity, calcium, potassium:sodium antiporter activity
GO BP Complete:	transmembrane transport, potassium ion transmembrane transport, calcium ion transport, calcium ion transmembrane transport, sodium ion transmembrane transport, intracellular calcium ion homeostasis
GO CC Complete:	membrane, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=20611\|UniProtKB=Q71RS6	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000007041.3\|UniProtKB=A0A2J8NTC3	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000015163.3\|UniProtKB=G3RGP2	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000018831.3\|UniProtKB=F6ZB51	Macaca mulatta	O
MOUSE\|MGI=MGI=2677271\|UniProtKB=Q8C261	Mus musculus	O
RAT\|RGD=1310565\|UniProtKB=A0A8I6GB53	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000004854.3\|UniProtKB=F1MIZ1	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000004662.5\|UniProtKB=A0A4X1SFS1	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000032930.3\|UniProtKB=A0A3Q2HAS1	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000022887.4\|UniProtKB=M3X5I5	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845018687.1\|UniProtKB=A0A8I3NX53	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000002761.4\|UniProtKB=F6YH24	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000050257.1\|UniProtKB=A0A6I8P2D5	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010018219.1\|UniProtKB=A0A8V0Z5G2	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000004764.4\|UniProtKB=H9G9H7	Anolis carolinensis	O
XENLA\|Gene=slc24a5.L\|UniProtKB=A0A1L8H0N1	Xenopus laevis	O
XENLA\|Gene=slc24a5.S\|UniProtKB=A0A8J0UQ45	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-853669\|UniProtKB=A0A6I8SU97	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000002760.2\|UniProtKB=A0A3B3ILY0	Oryzias latipes	O
DANRE\|Gene=slc24a5\|UniProtKB=Q49SH1	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000013255.1\|UniProtKB=W5N6S0	lepisosteus oculatus	O
BRAFL\|Gene=LOC118410309\|UniProtKB=A0A9J7KPF4	Branchiostoma floridae	O
BRAFL\|Gene=LOC118409489\|UniProtKB=A0A9J7KM11	Branchiostoma floridae	O
HUMAN\|HGNC=10978\|UniProtKB=Q8NFF2	Homo sapiens	O
GORGO\|Ensembl=ENSGGOG00000008151.3\|UniProtKB=G3QYN1	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000013960.4\|UniProtKB=F6S7H4	Macaca mulatta	O
MOUSE\|MGI=MGI=2447362\|UniProtKB=Q8CGQ8	Mus musculus	O
RAT\|RGD=1305926\|UniProtKB=A0A0G2K3S9	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000006620.6\|UniProtKB=F1MD60	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000002450.5\|UniProtKB=F1SD72	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000013708.4\|UniProtKB=F7BGF8	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000007887.5\|UniProtKB=M3W8K3	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845020809.1\|UniProtKB=A0A8I3PDR2	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000002100.4\|UniProtKB=F7G6D3	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000003823.3\|UniProtKB=F6T5Y9	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010015386.1\|UniProtKB=A0A8V0YS99	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000009184.3\|UniProtKB=A0A803SPZ8	Anolis carolinensis	O
XENLA\|Gene=LOC108698722\|UniProtKB=A0A1L8F9H8	Xenopus laevis	O
XENLA\|Gene=LOC108700484\|UniProtKB=A0A1L8F0F6	Xenopus laevis	O
XENTR\|Gene=slc24a4\|UniProtKB=A0A8J1IRG5	Xenopus tropicalis	O
XENTR\|Xenbase=XB-GENE-478288\|UniProtKB=F6YZS6	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000011649.2\|UniProtKB=H2M7Z7	Oryzias latipes	O
DANRE\|Gene=slc24a4a\|UniProtKB=A0A8M2B5T1	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-081031-75\|UniProtKB=F1QXK9	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000014107.1\|UniProtKB=W5N9S6	lepisosteus oculatus	O
HUMAN\|HGNC=10977\|UniProtKB=Q9HC58	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000013294.5\|UniProtKB=H2QK12	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000004364.3\|UniProtKB=G3QP00	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000002321.4\|UniProtKB=A0A1D5QCC5	Macaca mulatta	O
MOUSE\|MGI=MGI=2137513\|UniProtKB=Q99PD7	Mus musculus	O
RAT\|RGD=69256\|UniProtKB=Q9EPQ0	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000011882.6\|UniProtKB=E1BGG7	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000007100.5\|UniProtKB=F1SBG9	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000019334.4\|UniProtKB=F7DJ45	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000008015.6\|UniProtKB=M3W8T5	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845029352.1\|UniProtKB=A0A8I3Q687	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000005890.4\|UniProtKB=A0A5F8GQC2	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000015699.4\|UniProtKB=A0A6I8N328	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010018314.1\|UniProtKB=A0A8V0Z6S2	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000005176.4\|UniProtKB=G1KDR8	Anolis carolinensis	O
XENLA\|Gene=LOC108717769\|UniProtKB=A0A1L8G1S1	Xenopus laevis	O
XENLA\|Gene=LOC108716110\|UniProtKB=A0A8J1KMQ5	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-494358\|UniProtKB=F7E255	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000025860.1\|UniProtKB=A0A3B3I4R7	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000007407.2\|UniProtKB=H2LT67	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-100922-39\|UniProtKB=A0A8M9QL19	Danio rerio	O
DANRE\|Gene=LOC101886560\|UniProtKB=A0A8M9QI78	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000002679.1\|UniProtKB=W5M455	lepisosteus oculatus	O
ORYLA\|Ensembl=ENSORLG00000000303.2\|UniProtKB=H2L3P7	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000002454.2\|UniProtKB=H2LAY1	Oryzias latipes	O
DANRE\|Gene=slc24a3\|UniProtKB=A0A8N7T746	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000016155.1\|UniProtKB=W5NH05	lepisosteus oculatus	O
BRAFL\|Gene=LOC118425860\|UniProtKB=A0A9J7LXC6	Branchiostoma floridae	O
BRAFL\|Gene=LOC118409222\|UniProtKB=A0A9J7KLV7	Branchiostoma floridae	O
BRAFL\|Gene=LOC118423459\|UniProtKB=A0A9J7LR76	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC592113\|UniProtKB=A0A7M7N7L9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC580359\|UniProtKB=A0A7M7NBF4	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115919082\|UniProtKB=A0A7M7PRH3	Strongylocentrotus purpuratus	O
DROME\|FlyBase=FBgn0039941\|UniProtKB=Q7PLW4	Drosophila melanogaster	LDO
TRICA\|EnsemblGenome=TC013320\|UniProtKB=D6WM87	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_207878\|UniProtKB=E9G011	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW007235\|UniProtKB=B7PW42	Ixodes scapularis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g85050\|UniProtKB=A7RKL4	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g198469\|UniProtKB=A7RKL3	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g134893\|UniProtKB=A7SW69	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG33154\|UniProtKB=B3SCB1	Trichoplax adhaerens	O
ENTH1\|EnsemblGenome=CL6EHI_018640\|UniProtKB=C4MA70	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=EHI_049410\|UniProtKB=C4LUE3	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_049310\|UniProtKB=C4LUD3	Entamoeba histolytica	O
PARTE\|EnsemblGenome=GSPATT00007604001\|UniProtKB=A0CH97	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00014844001\|UniProtKB=A0DA70	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPSDRAFT_4973\|UniProtKB=B8C1L5	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_10292\|UniProtKB=B8CDR0	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_bd1662\|UniProtKB=B8LEG5	Thalassiosira pseudonana	O
NITMS\|EnsemblGenome=Nmar_0590\|UniProtKB=A9A357	Nitrosopumilus maritimus	O
SACS2\|EnsemblGenome=SSO1174\|UniProtKB=Q97YX8	Sulfolobus solfataricus	O
SACS2\|EnsemblGenome=SSO3192\|UniProtKB=Q97U31	Sulfolobus solfataricus	O
METAC\|EnsemblGenome=MA_2817\|UniProtKB=Q8TM51	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_3021\|UniProtKB=Q8TLL5	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_2008\|UniProtKB=Q8TPA6	Methanosarcina acetivorans	O
METJA\|EnsemblGenome=MJ_0091\|UniProtKB=Q57556	Methanocaldococcus jannaschii	O
HALSA\|EnsemblGenome=VNG_2257G\|UniProtKB=Q9HN44	Halobacterium salinarum	O
HALSA\|EnsemblGenome=VNG_0380G\|UniProtKB=Q9HS69	Halobacterium salinarum	O
THEKO\|EnsemblGenome=TK0867\|UniProtKB=Q5JI20	Thermococcus kodakaraensis	O
CHLAA\|EnsemblGenome=Caur_1857\|UniProtKB=A9WDA7	Chloroflexus aurantiacus	O
CHLAA\|EnsemblGenome=Caur_2211\|UniProtKB=A9WFS0	Chloroflexus aurantiacus	O
THEMA\|EnsemblGenome=TM_0724\|UniProtKB=Q9WZI3	Thermotoga maritima	O
SYNY3\|Gene=P72945_SYNY3\|UniProtKB=P72945	Synechocystis	O
BACTN\|EnsemblGenome=BT_3019\|UniProtKB=Q8A3D5	Bacteroides thetaiotaomicron	O
RHOBA\|EnsemblGenome=RB1641\|UniProtKB=Q7UX07	Rhodopirellula baltica	O
AQUAE\|EnsemblGenome=aq_066\|UniProtKB=O66480	Aquifex aeolicus	O
THEYD\|EnsemblGenome=THEYE_A0130\|UniProtKB=B5YHF9	Thermodesulfovibrio yellowstonii	O
COXBU\|EnsemblGenome=CBU_0095\|UniProtKB=Q83F54	Coxiella burnetii	O
SHEON\|Gene_OrderedLocusName=SO_0354\|UniProtKB=Q8EJV2	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_2522\|UniProtKB=Q9KP54	Vibrio cholerae	O
SALTY\|EnsemblGenome=STM3314\|UniProtKB=Q8ZLS2	Salmonella typhimurium	O
YERPE\|Gene_OrderedLocusName=YPO3576\|UniProtKB=A0A2U2H2F5	Yersinia pestis	O
ECOLI\|EnsemblGenome=BAE77240\|UniProtKB=P45394	Escherichia coli	O