PANTHER Gene Information

Gene Symbol(s):

icmt-2

Organism:

Dictyostelium discoideum

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Gene Name:

Protein-S-isoprenylcysteine O-methyltransferase

Gene ID:

DDB_G0272799

Protein ID:

Q558K8

Persistent Id:

PTN000295662

Alternate Ids:

EAL71037(Ensembl_PRO)	Prenylated protein carboxyl methyltransferase(Synonym)
AAFI02000009(EMBL)	DDB_G0273995(dictyBase)
DDB_G0273995(Ensembl)	EAL70431(EMBL-CDS)
Q86AM7(AltAccession)	111226897(GI)
XP_644356(refSeq)	2.1.1.100 {ECO:0000250\|UniProtKB:D6WJ77}(EC)
ICMT_DICDI(UniProtKB-ID)	EAL70431(Ensembl_TRS)
8618733(GeneID)	icmt-1(Symbol)
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PANTHER Classification

PANTHER Family:	PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE (PTHR12714)
PANTHER Subfamily:	PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE (PTHR12714:SF9)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class:	protein modifying enzyme

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	methyltransferase activity, protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
GO BP Complete:	regulation of aggregation involved in sorocarp development, nuclear envelope organization, C-terminal protein methylation, establishment of cell polarity, regulation of G protein-coupled receptor signaling pathway, protein localization to nucleus, methylation
GO CC Complete:	endoplasmic reticulum membrane, membrane, endoplasmic reticulum

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Post-translational protein modification, Metabolism of proteins

Orthologs

ID	Organism	Type
HUMAN\|HGNC=5350\|UniProtKB=O60725	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000000079.6\|UniProtKB=H2PXW4	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000005058.3\|UniProtKB=G3QQT1	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000018350.4\|UniProtKB=F7H607	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1888594\|UniProtKB=Q9EQK7	Mus musculus	LDO
RAT\|RGD=621618\|UniProtKB=Q9WVM4	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000048308.2\|UniProtKB=G3N1V4	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00005017639.1\|UniProtKB=A0A4X1W2Y0	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000024730.4\|UniProtKB=A0A5F5PKT3	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000019179.5\|UniProtKB=A0A337SXQ5	Felis catus	LDO
MONDO\|Ensembl=ENSMODG00000006189.3\|UniProtKB=A0A5F8HIQ5	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000002730.3\|UniProtKB=F6U9Y3	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010019189.1\|UniProtKB=Q5ZMU7	Gallus gallus	LDO
XENLA\|Gene=icmt\|UniProtKB=O12947	Xenopus laevis	LDO
XENLA\|Gene=icmt.L\|UniProtKB=A0A1L8FMH7	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-976857\|UniProtKB=F7EBZ7	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000019374.2\|UniProtKB=H2MYN0	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-050417-90\|UniProtKB=Q568J7	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000004867.1\|UniProtKB=W5MBU2	lepisosteus oculatus	LDO
BRAFL\|Gene_ORFName=BRAFLDRAFT_265706\|UniProtKB=C3ZIC0	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC590850\|UniProtKB=A0A7M7REG9	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00017673\|UniProtKB=P91266	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00019710\|UniProtKB=P91402	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00035270\|UniProtKB=A8XKX6	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00097978\|UniProtKB=A0A2A6B4S5	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0036336\|UniProtKB=Q9VU37	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP001310\|UniProtKB=Q7PXA7	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC013078\|UniProtKB=D6WJ77	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_300937\|UniProtKB=E9HFQ3	Daphnia pulex	LDO
HELRO\|EnsemblGenome=HelroG105479\|UniProtKB=T1EDV4	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g231956\|UniProtKB=A7RLB3	Nematostella vectensis	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g150206\|UniProtKB=A7T8G9	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG57388\|UniProtKB=B3RZB1	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_7483\|UniProtKB=A9UX32	Monosiga brevicollis	LDO
YEAST\|SGD=S000002818\|UniProtKB=P32584	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_AAR122C\|UniProtKB=Q75EF9	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000201217\|UniProtKB=A0A1D8PPJ9	Candida albicans	O
CANAL\|CGD=CAL0000199995\|UniProtKB=A0A1D8PPI7	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_E22913g\|UniProtKB=Q6C4X7	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_06162\|UniProtKB=C8V246	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_2G14380\|UniProtKB=Q4X082	Neosartorya fumigata	O
ASPFU\|EnsemblGenome=AFUA_2G08420\|UniProtKB=Q4X1X7	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU00034\|UniProtKB=U9W347	Neurospora crassa	LDO
PHANO\|EnsemblGenome=SNOG_12797\|UniProtKB=Q0U617	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPAC10F6.12c\|UniProtKB=P87014	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_05016\|UniProtKB=B6K8D8	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNC01050\|UniProtKB=Q5KL21	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_11682\|UniProtKB=A0A0D1E2N4	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_17481\|UniProtKB=E3L5B9	Puccinia graminis	LDO
PUCGT\|EnsemblGenome=PGTG_18534\|UniProtKB=E3L7L1	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_15792\|UniProtKB=F4NXA7	Batrachochytrium dendrobatidis	LDO
ENTH1\|EnsemblGenome=CL6EHI_045150\|UniProtKB=C4LTC8	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_006100\|UniProtKB=C4M2P4	Entamoeba histolytica	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_58140\|UniProtKB=F0ZZB8	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_35_3030\|UniProtKB=E9AFC7	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb09.211.3640\|UniProtKB=Q38DE5	Trypanosoma brucei	LDO
GIAIC\|Gene_ORFName=GL50803_0017013\|UniProtKB=A0A644FBI9	Giardia intestinalis	LDO
TRIV3\|Gene_ORFName=TVAG_476130\|UniProtKB=A2DA36	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_470080\|UniProtKB=A2FE15	Trichomonas vaginalis	LDO
TRIV3\|Gene_ORFName=TVAG_459020\|UniProtKB=A2E6A7	Trichomonas vaginalis	O
THAPS\|EnsemblGenome=THAPSDRAFT_36679\|UniProtKB=B8LBH8	Thalassiosira pseudonana	O
CHLRE\|EnsemblGenome=CHLRE_03g145427v5\|UniProtKB=A0A2K3DVA4	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_03g145247v5\|UniProtKB=A8J328	Chlamydomonas reinhardtii	O
PLAF7\|EnsemblGenome=PF3D7_1236800\|UniProtKB=Q8I555	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00010834001\|UniProtKB=A0CV49	Paramecium tetraurelia	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_33310\|UniProtKB=B8C046	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3GPT4_PHYRM\|UniProtKB=H3GPT4	Phytophthora ramorum	LDO
PHYRM\|Gene=H3H5Z3_PHYRM\|UniProtKB=H3H5Z3	Phytophthora ramorum	LDO
AMBTC\|EnsemblGenome=AMTR_s00019p00236540\|UniProtKB=W1PJT8	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_19G00710\|UniProtKB=A0A0K9PNE2	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma00_g01910\|UniProtKB=A0A804HMF2	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_010027mg\|UniProtKB=K3Y736	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3001G515000\|UniProtKB=C5WZ17	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb144100\|UniProtKB=A0A804N920	Zea mays	LDO
ORYSJ\|Gene_OrderedLocusName=LOC_Os04g51380\|UniProtKB=Q7XSR9	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_5g20780v3\|UniProtKB=A0A2K2CIE5	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.2HG0193080\|UniProtKB=A0A8I7B816	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS2A02G436900\|UniProtKB=A0A3B6B4K1	Triticum aestivum	LDO
WHEAT\|EnsemblGenome=TraesCS2B02G456300\|UniProtKB=A0A3B6CEG1	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2D02G433000\|UniProtKB=A0A3B6DHZ7	Triticum aestivum	LDO
NELNU\|Gene=LOC104612300\|UniProtKB=A0A1U8BLV8	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110791090\|UniProtKB=A0A9R0IMB6	Spinacia oleracea	LDO
SPIOL\|Gene=LOC110803399\|UniProtKB=A0A9R0KBD4	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr01g0016201\|UniProtKB=A0A251VMG7	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C500291370\|UniProtKB=A0A9R1VE93	Lactuca sativa	O
HELAN\|EnsemblGenome=HanXRQr2_Chr17g0811211\|UniProtKB=A0A251RRU5	Helianthus annuus	O
HELAN\|Gene_ORFName=HanXRQr2_Chr08g0361341\|UniProtKB=A0A9K3IIR0	Helianthus annuus	LDO
HELAN\|Gene_ORFName=HannXRQ_Chr08g0237151\|UniProtKB=A0A251U9J6	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C900465550\|UniProtKB=A0A9R1UCF4	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a024304mg\|UniProtKB=A0A022QXN1	Erythranthe guttata	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a0141642mg\|UniProtKB=A0A022Q5K8	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_14161\|UniProtKB=A0A2G2ZGM0	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400011510\|UniProtKB=M1ATM9	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc01g057852.1\|UniProtKB=A0A3Q7EXU5	Solanum lycopersicum	O
SOLLC\|EnsemblGenome=Solyc05g024325.1\|UniProtKB=A0A3Q7HBY9	Solanum lycopersicum	O
SOLLC\|EnsemblGenome=Solyc04g009010.2\|UniProtKB=A0A3Q7GPQ0	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107821842\|UniProtKB=A0A1S4CRT3	Nicotiana tabacum	O
TOBAC\|Gene=LOC107811658\|UniProtKB=A0A1S4BTG6	Nicotiana tabacum	LDO
VITVI\|EnsemblGenome=Vitvi12g02536\|UniProtKB=D7TR52	Vitis vinifera	O
VITVI\|EnsemblGenome=Vitvi10g01477\|UniProtKB=D7TES1	Vitis vinifera	O
VITVI\|Gene_OrderedLocusName=VIT_12s0028g00250\|UniProtKB=D7TR53	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_G02666\|UniProtKB=A0A059BHM0	Eucalyptus grandis	O
EUCGR\|EnsemblGenome=EUGRSUZ_D01405\|UniProtKB=A0A059CFP7	Eucalyptus grandis	O
EUCGR\|EnsemblGenome=EUGRSUZ_G02601\|UniProtKB=A0A059BFU6	Eucalyptus grandis	LDO
BRACM\|EnsemblGenome=Bra005985\|UniProtKB=M4CP47	Brassica campestris	LDO
ARATH\|TAIR=locus=2166963\|UniProtKB=Q9FMW9	Arabidopsis thaliana	O
ARATH\|TAIR=locus=505006585\|UniProtKB=Q93W54	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107913618\|UniProtKB=A0A1U8KAV3	Gossypium hirsutum	O
GOSHI\|Gene=LOC107891127\|UniProtKB=A0A1U8HZ65	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_025813\|UniProtKB=A0A061F188	Theobroma cacao	O
GOSHI\|Gene=LOC107931206\|UniProtKB=A0A1U8LV86	Gossypium hirsutum	O
GOSHI\|Gene=LOC107946091\|UniProtKB=A0A1U8NCU4	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_007686\|UniProtKB=A0A061E203	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g040990mg\|UniProtKB=A0A067FR66	Citrus sinensis	O
CITSI\|Gene_ORFName=CISIN_1g029059mg\|UniProtKB=A0A067EIY8	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_007G074500v3\|UniProtKB=A0A2K1ZQR2	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_005G089500v3\|UniProtKB=B9H5P5	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_08G039100\|UniProtKB=A0A2C9VD85	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_0408950\|UniProtKB=B9T7U4	Ricinus communis	O
RICCO\|Gene_ORFName=RCOM_0037200\|UniProtKB=B9T024	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_09G169200\|UniProtKB=K7LEE2	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_16G218800\|UniProtKB=I1MQM8	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_6g075160\|UniProtKB=A0A072ULV3	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr16_08100\|UniProtKB=A0A2I4FBI1	Juglans regia	LDO
JUGRE\|EnsemblGenome=Jr16_08090\|UniProtKB=A0A2I4FBG5	Juglans regia	LDO
JUGRE\|EnsemblGenome=Jr13_20320\|UniProtKB=A0A2I4ED04	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_6G074600\|UniProtKB=A0A0A0KCT2	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_1G348900\|UniProtKB=A0A251R8Q2	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_124841\|UniProtKB=D8STV8	Selaginella moellendorffii	LDO
SELML\|EnsemblGenome=SELMODRAFT_91230\|UniProtKB=D8RE73	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c3_35430\|UniProtKB=A0A2K1KXE2	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0062s0094\|UniProtKB=A0A2R6WS93	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_001070220\|UniProtKB=A0A1Y1I0L9	Klebsormidium nitens	LDO
METAC\|EnsemblGenome=MA_2249\|UniProtKB=Q8TNN5	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_2698\|UniProtKB=Q8TMG0	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_1000\|UniProtKB=Q8TS08	Methanosarcina acetivorans	LDO
STRCO\|Gene_OrderedLocusName=SCO7670\|UniProtKB=Q9EWQ7	Streptomyces coelicolor	O
MYCTU\|Gene_OrderedLocusName=Rv1139c\|UniProtKB=O06539	Mycobacterium tuberculosis	O
STRR6\|EnsemblGenome=spr1996\|UniProtKB=Q8DN04	Streptococcus pneumoniae	O
STAA8\|EnsemblGenome=SAOUHSC_00182\|UniProtKB=Q2G1E3	Staphylococcus aureus	O
BACSU\|EnsemblGenome=BSU_22040\|UniProtKB=P54158	Bacillus subtilis	O
DEIRA\|EnsemblGenome=DR_1745\|UniProtKB=Q9RTL5	Deinococcus radiodurans	O
MYCTU\|Gene_OrderedLocusName=Rv2437\|UniProtKB=P71912	Mycobacterium tuberculosis	LDO
BRADU\|Gene=Q89C07_BRADU\|UniProtKB=Q89C07	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89PI3_BRADU\|UniProtKB=Q89PI3	Bradyrhizobium diazoefficiens	LDO
GLOVI\|Gene=Q7NHS4_GLOVI\|UniProtKB=Q7NHS4	Gloeobacter violaceus	O
SYNY3\|Gene=P74711_SYNY3\|UniProtKB=P74711	Synechocystis	O
RHOBA\|EnsemblGenome=RB11248\|UniProtKB=Q7UEM3	Rhodopirellula baltica	O
GEOSL\|EnsemblGenome=GSU1926\|UniProtKB=Q74BV6	Geobacter sulfurreducens	O
BRADU\|Gene=Q89FY3_BRADU\|UniProtKB=Q89FY3	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89EQ9_BRADU\|UniProtKB=Q89EQ9	Bradyrhizobium diazoefficiens	O
VIBCH\|EnsemblGenome=VC_1199\|UniProtKB=Q9KSQ7	Vibrio cholerae	O
XANCP\|EnsemblGenome=XCC0325\|UniProtKB=Q8PDL0	Xanthomonas campestris	O